Helicobacter pylori Detection by Polymerase Chain Reaction of the Gene Encoding 16S Ribosomal RNA in Fresh and Paraffin-Embedded Material

The molecular revolution--coming your way soon.

“…Specific 16S rRNA primers can also be designed as described for organisms such as Helicobacter pylo. 34 Oncology In oncology the use of PCR is currently limited to the identification of translocations, monoclonality,35 and of minimal residual disease36 before clinical relapse in lymphomas. However, should any of the recently described molecular abnormalities of colorectal cancer (Kirsten-ras,5 the DCC gene,6 p53 deletion,4 the APC gene7'8) prove to have value in diagnosis or prognosis then these can be rapidly used.…”