Helicobacter pylori Eradication Therapy

Huang, Jie; Hunt, Richard H.

doi:10.1007/978-1-4615-0681-2_5

Cited by 2 publications

(2 citation statements)

References 47 publications

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“…The results of multifactorial unconditional logistic regression showed that the level of HDL in the Hp-infected group was lower than that in the Hp-uninfected group. the higher the level of HDL, the lower the risk of Hp infection in patients with H-type hypertension, which is consistent with the statement that HDL cholesterol is the "good cholesterol" [26] , and with the findings of Huang Zhen [27] et al The results of IWAI [28] et al also showed that Hp infection was closely associated with lipid profile.HDL is a heterogeneous lipoprotein complex composed of multiple proteins and lipids, and the possible reasons for this phenomenon are as follows: (1) The reduced risk of Hp infection is closely related to the antioxidant effect of HDL. By modulating various antioxidant enzymes contained in HDL particles, such as elevated levels of lecithin-cholesterol acyltransferase (LCAT), cholesteryl ester transfer protein, hepatic lipase, and reduced levels of endothelial lipase, all lead to increased levels of high-density lipoprotein cholesterol (HDL-C) [29,30] , in addition to glutathione peroxidase in HDL, platelet-activating factor-acetyl hydrolase (PAF-AH) and paraoxonase (PON) in HDL are also closely associated with anti-inflammatory properties to resist H. pylori invasion [31] ; (2) the reduced risk of Hp infection is closely associated with HDL-regulated immune response.…”

Section: Discussionsupporting

confidence: 88%

Analysis of influencing factors associated with Hp infection in H-type hypertension

2023

AJMHS

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Objective to investigate the influencing factors of Helicobacter pylori (Hp) infection in patients with H type hypertension. Methods A total of 1089 patients with h-type hypertension who underwent physical examination in Lanzhou PetrochemicalCompany of petrochina in Lanzhou city, Gansu Province from May 2021 to September 2021 were selected as the research objects. All the patients were tested by 14C urea breath test and divided into Hp infected group (278 cases) and Hp non-infected group (811 cases) according to the test results. For collected age, sex and other general demographic indicators and determined systolic blood pressure (SBP) diastolic blood pressure (DBP) albumin (ALB) globulin (GLB) total protein (TP) albumin/globulin (ALB/GLB) uric acid (UA) triglyceride (TG) Total cholesterol (TC) High-density lipoprotein (HDL) Low density lipoprotein (LDL) fasting blood glucose (GLU) and other biochemical indicators were analyzed by univariate analysis and multivariate unconditiona Logistic regression analysis. Results Univariate analysis showed that albumin (ALB) in h-type hypertension patients in infection group was lower than that in lung infectiongroup, and the difference was statistically significant (T =3.383, P<0.05). Systolic blood pressure (SBP), globulin (GLB), triglyceride (TG) and fasting blood glucose (GLU) were higher than those in the non-infected group, but the differences were not statistically significant (ALL P>0.05). Diastolic blood pressure (DBP), total protein (TP), uric acid (UA), total cholesterol (TC) and low density lipoprotein (LDL) were higher than those in the non-infected group. There were no significant differences (all P>0.05); Multivariate non-conditional Logistic regression showed that high density lipoprotein (DHL) was an independent protective factor for Hp infection in h-type hypertension patients (OR=0.49, P<0.05). Conclusions Hp infection is associated with lipid metabolism disorder, and high density lipoprotein is a protective factor of HELICobacter pylori infection in patients with H type hypertension.

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Section: Discussionsupporting

confidence: 88%

Analysis of influencing factors associated with Hp infection in H-type hypertension

2023

AJMHS

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“…Finally, 101 RCTs 14,23–122 involving 21,745 patients met the inclusion criteria and were eligible for our meta-analysis (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

The Efficacy and Safety of Regimens for Helicobacter pylori Eradication Treatment in China

Li,

Shi,

Zhou

et al. 2023

Journal of Clinical Gastroenterology

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Background: With Helicobacter pylori’s increasing antibiotic resistance, evidence of more effective treatments is lacking in China, where H. pylori prevalence is nearly 50%. Thus, we performed a network meta-analysis to compare therapeutic regimens. Methods: Data extracted from eligible randomized controlled trials from January 2000 to September 2021 were entered into a Bayesian hierarchical random-effects model to evaluate the efficacy and safety of H. pylori eradication regimens. Results: This study included 101 trials involving 21,745 patients. Vonoprazan-bismuth–containing quadruple therapy (VBQT) ranked the highest [surfaces under cumulative ranking curve (SUCRA), 83.64%], followed by high-dose amoxicillin dual therapy (HDDT) [SUCRA, 79.70%, odds ratio (OR)=1.31, 95% credible interval (CrI) (0.36, 4.72)] and proton pump inhibitor-based bismuth-containing quadruple therapy (BQT) [SUCRA, 63.59%, OR=1.59, 95% CrI (0.48, 5.24)]. HDDT [OR=2.47, 95% CrI (1.51, 4.06)], BQT [OR=2.04, 95% CrI (1.69, 2.47)], concomitant quadruple nonbismuth therapy (CT) [OR=1.93, 95% CrI (1.19, 3.15)], and sequential therapy (ST) [OR=1.86, 95% CrI (1.50, 2.32)] had higher eradication rates than standard triple therapy (TT). ST (SUCRA, 82.52%) and VBQT (SUCRA, 83.89%) had the highest eradication rate before and after 2010 in the effectiveness ranking, respectively. Furthermore, the H. pylori eradication rate of patients receiving 14-day BQT treatment was higher than that of 10-day BQT regimen [OR=2.55, 95% CI (1.84, 3.53)] and 7-day BQT regimen [OR=3.64, 95% CI (2.64, 5.01)]. Conclusions: The TT regimen was not an optimal choice in China for H. pylori eradication; VBQT, HDDT, and BQT showed better efficacy. After 2010, there is a trend toward significance that VBQT provided a higher H. pylori eradication rate in China, but with only 1 randomized controlled trial. Thus, more supportive real-world data are needed to confirm its effectiveness.

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Helicobacter pylori Eradication Therapy

Cited by 2 publications

References 47 publications

Analysis of influencing factors associated with Hp infection in H-type hypertension

Analysis of influencing factors associated with Hp infection in H-type hypertension

The Efficacy and Safety of Regimens for Helicobacter pylori Eradication Treatment in China

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