Helicobacter Pylori vacA d1 Genotype is associated with Gastric Cancer but not Peptic Ulcers in Kurdistan Region, Northern Iraq

Hussein, Nawfal R.

doi:10.7314/apjcp.2014.15.14.5965

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Several H. pylori virulence factors, including cagA and vacA, have been reported to be associated with the clinical outcomes (Weel et al, 1996;Wotherspoon et al, 1999;Cettelly et al, 2002;Yamaoka., 2010). Recently, H. pylori vacA d1 genotype was reported to be associated with gastric cancer in Iraq (Hussein, 2014) and Iran (Basiri et al, 2014). Seroreactivity to the 89kDa (vacA) protein was also significantly higher in gastric cancer patients in Iran (Karami et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Virulence Genes of Helicobacter pylori in Gastritis, Peptic Ulcer and Gastric Cancer in Laos

Vannarath

Vilaichone²,

Rasachak³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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cagA was detected in 99.2%. East-Asian-type cagA (62%) and vacA s1c (64.7%) were predominant genotypes in Laos. vacA s1c-m1b was significantly higher in GU than gastritis (53.8% vs. 24.1%; P-value=0.04) whereas vacA s1a-m2 was significantly higher in DU than gastritis (40.0% vs. 16.9%; P-value=0.03). East-Asian-type cagA and vacA s1c were significantly higher in highland than lowland Lao (100% vs. 55.8%; P-value=0.001 and 88.2% vs. 61.5%, P-value=0.03 respectively). Conclusions: H. pylori is a common infection in

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Section: Introductionmentioning

confidence: 99%

Virulence Genes of Helicobacter pylori in Gastritis, Peptic Ulcer and Gastric Cancer in Laos

Vannarath

Vilaichone²,

Rasachak³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Helicobacter pylori‐related risk predictors of gastric cancer: The latest models, challenges, and future prospects

2020

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Helicobacter pylori is known as an important determinant of preneoplastic lesions or gastric cancer (GC) risk. The bacterial genotypes may determine the clinical outcomes. However, the evidence for these associations has varied between and within continents, and the actual effect of each gene and corresponding allelic variants are still debatable. In recent years, two new models have been proposed to predict the risk of GC; the phylogeographic origin of H. pylori strains and a disrupted co‐evolution between H. pylori and its human host, which potentially explain the geographic differences in the risk of H. pylori‐related cancer. However, these models and earlier ones based on putative virulence factors of the bacterium may not fully justify differences in the incidence of GC, reflecting that new theories should be developed and examined. Notably, the new findings also support the role of ancestry‐specific germline alteration in contributing to the ethnic/population differences in cancer risk. Moreover the high and low incidence areas of GC have shown differences in transmission ecology, largely affecting the composition of H. pylori populations. As a new hypothesis, it is proposed that any high‐risk population may have its own specific risk loci (or variants) as well as new H. pylori strains with national/maybe regional gene pools that should be considered. The latter is seen in the Americas where the rapid evolution of distinct H. pylori subpopulations has been occurred. It is therefore proposed that the deep sequencing of both H. pylori and its human host is simultaneously performed in GC patients and age‐sex‐matched controls from high‐risk areas. The expression and functional activities of the identified new determinants of GC must then be assessed and matched with human and pathogen ancestry, because some of risk loci are ancestry‐specific. In addition, potential study‐level covariates and moderator variables (eg physical conditions, life styles, gastric microbiome, etc) linked to causal relationships, and their impact, should be recognized and controlled.

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Helicobacter pylori Genetic Polymorphisms in Gastric Disease Development

Whitmire

Merrell

2019

Advances in Experimental Medicine and Biology

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Helicobacter Pylori vacA d1 Genotype is associated with Gastric Cancer but not Peptic Ulcers in Kurdistan Region, Northern Iraq

Cited by 3 publications

References 5 publications

Virulence Genes of Helicobacter pylori in Gastritis, Peptic Ulcer and Gastric Cancer in Laos

Virulence Genes of Helicobacter pylori in Gastritis, Peptic Ulcer and Gastric Cancer in Laos

Helicobacter pylori‐related risk predictors of gastric cancer: The latest models, challenges, and future prospects

Helicobacter pylori Genetic Polymorphisms in Gastric Disease Development

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