Hematologic Abnormalities in the Small Animal Cancer Patient

Childress, Michael O.

doi:10.1016/j.cvsm.2011.09.009

Cited by 48 publications

(57 citation statements)

References 174 publications

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“…In dogs with primary neoplasms, neutrophilic leukocytosis, detected in 45.8% of sampled animals, may be attributed to inflammation or tissue necrosis associated with mammary cancer or triggered by chronic stress (Childress 2012). In malignant cases, there may be an elevation in the circulating levels of hematopoietic growth factors, causing an increase in the production and release of neutrophils; however, this mechanism has not been fully elucidated yet.…”

Section: Discussionmentioning

confidence: 98%

“…In the present study, six (25%) out of 11 animals with neutrophilic leukocytosis had concomitant monocytosis, which corroborates the presence of a chronic infection, tumor, or tissue necrosis (Stockham et al 2003) in female dogs with mammary neoplasms. Eosinophilia, detected in 33.3% of sampled animals, has already been associated with several tumors and with anaplastic mammary carcinoma (Losco 1986), even though it is seldom observed in patients with solid tumors (Childress 2012). It is assumed that other cytokines may be released during tumor growth, such as TNF-α, IL-1, IL-6, and IL-5, one of the cytokines in charge of eosinophil production (Radin & Wellman 2010).…”

Section: Discussionmentioning

confidence: 99%

“…These cytokines sequester iron, reduce erythrocyte half-life (IL-1), and also reduce erythropoietin release (TNF and IL-6). In addition, microangiopathic hemolytic anemia and immune-mediated hemolytic anemia have already been described in mammary carcinoma (Mangieri 2009); however, the most relevant cause of nonregenerative anemia in cancer patients is believed to be anemia of chronic disease, also known as anemia of inflammation (Childress 2012). There are few studies that evaluate the association of hematological condition with mammary neoplasm, but the results are similar, considering that normocytic, normochromic anemia was previously observed in 11.2% (11/161) of dogs (Silva et al 2014), whereas another study only indicated a reduction in erythrocyte levels in bitches with mammary carcinoma compared with a control group (Estrela-Lima et al 2012).…”

Section: Discussionmentioning

confidence: 99%

“…In human medicine, thrombocytosis is a clinically important finding often detected in cancer patients, but there is a paucity of reports on this condition in veterinary oncology (Childress 2012, Bergman 2013. In dogs, studies have given contradictory results, although it is a common finding (Hammer 1991), observed in 33.3% of sampled animals.…”

Section: Discussionmentioning

confidence: 99%

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Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms

et al. 2017

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RESUMO.-[Anormalidades hematológicas, bioquímicas e hemostáticas de origem paraneoplásica em fêmeas caninas com neoplasia mamária.] Alterações laboratoriais de origem paraneoplásica são identificadas em diversos tipos de câncer de cães e gatos. Na medicina veteriná-ria, existem poucos estudos que correlacionam os achados laboratoriais anormais com o tipo e estadiamento tumorais, principalmente em cadelas com neoplasia mamária. O objetivo deste estudo foi avaliar as alterações hematológi-cas, bioquímicas e hemostáticas em cadelas com neoplasia mamária e relacioná-las com o estadiamento tumoral. Foram coletadas amostras de sangue de 24 fêmeas caninas, e os parâmetros hematológicos, bioquímicos e hemostáticos obtidos foram relacionados com o estadiamento tumoral, realizado através do exame físico, exames de imagem e avaliação histopatológica após remoção cirúrgica. Os grupos foram organizados de acordo com o estadiamento tumoral em: Grupo 1 (estádios I e II), grupo 2 (estádio III) e grupo 3 (estádios IV e V). Observou-se anemia, leucocitose neutrofílica, monocitose, eosinofilia, trombocitose, hipoalbuminemia, hipocalcemia, hipoglicemia e diminuição de ureia sanguínea. As variáveis CHCM, PPT e RDW foram relacionadas com o estadiamento tumoral, porém sem relevância clínica. Nos testes de coagulação, o TT e o fibrinogênio apresentaram diferença significativa entre os grupos, sendo associado com estadiamento tumoral. Os resultados sugerem in- Paraneoplastic laboratory abnormalities are identified in several types of cancers in dogs and cats. In veterinary medicine, particularly in mammary cancer, there are few studies that correlate abnormal laboratory findings with tumor type and staging. The aim of this study was to evaluate hematological, biochemical, and hemostatic abnormalities and correlate them with mammary tumor staging in female dogs with mammary cancer. Blood samples from 24 female dogs were evaluated, and the hematological, biochemical, and hemostatic parameters were correlated with tumor staging obtained by physical examination, imaging exams, and histopathological surgical biopsies. The groups were organized according to tumor staging: group 1 (stages I and II), group 2 (stage III), and group 3 (stages IV and V). Anemia, neutrophilic leukocytosis, monocytosis, eosinophilia, thrombocytosis, hypoalbuminemia, hypocalcemia, hypoglycemia, and low blood urea were observed. The variables MCHC, TPP, and RDW were correlated with tumor staging with no clinical relevance. Thrombin time and fibrinogen were significant between the groups in the coagulation test, being associated with tumor staging. The findings suggest influence of the proinflammatory cytokines released during tumor growth.INDEX TERMS: Hyperfibrinogenemia, mammary tumor staging, paraneoplastic syndromes, laboratory parameters.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms

et al. 2017

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“…Em animais com neoplasias é comum à ocorrência de alterações hematológicas como anemia e trombocitopenia, porém existem poucos relatos, sobre a incidência, prevalência e sua importância clínica, apesar de ser descrita na literatura veterinária (Childress, 2012). Para Coussens and Werb (2002) as agressões aos tecidos causadas pelos tumores, provocam uma resposta inflamatória a fim de sanar as lesões desencadeadas, para isso ocorre à liberação de leucócitos como neutrófilos, monócitos, e eosinófilos na corrente sanguínea, para que alcancem o local acometido.…”

Section: Resultado E Discussãounclassified

Avaliação da resposta inflamatória sistêmica induzida por carcinoma ductal in situ em cadelas

Braz

Sartoretto

Lima

et al. 2018

Pubvet

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RESUMO. Em tumores mamários, é comum alterações inflamatórias, causadas principalmente em neoplasias que metastatizam. Este trabalho tem por objetivo avaliar a concentração de Proteína C Reativa (PCR), correlacionada as alterações de proteínas totais e albumina em cadelas com carcinoma ductal in situ e demonstrar as alterações hematológicas encontradas. Foram utilizadas 13 cadelas diagnosticadas com carcinoma ductal in situ, triados pelo exame citopatológico e confirmado pela histopatologia. Concluise que a PCR é uma proteína de fase aguda que se eleva independente das proteínas totais e albumina e as alterações hematológica são de pouca relevância para o diagnóstico de carcinoma ductal in situ.Palavras chave: proteínas de fase aguda, inflamação, tumor mamário canino, biomarcadores Evaluation of systemic inflammatory response induced by ductal carcinoma in situ in dogs ABSTRACT. In breast tumors, inflammatory changes are common, mainly caused by neoplasias that metastasize. This work aims to evaluate the concentration of C Reactive Protein (CRP), correlating the alterations of total proteins and albumin in dogs with ductal carcinoma in situ and to demonstrate the hematological alterations found. Thirteen dogs diagnosed with ductal carcinoma in situ were screened by cytopathological examination and confirmed by histopathology. It is concluded that CRP is an acute phase protein that rises independently of total proteins and albumin and hematological changes are of little relevance for the diagnosis of ductal carcinoma in situ.Keywords: acute phase proteins, inflammation, canine mammary tumor, biomarkers Evaluación de la respuesta inflamatoria sistémica inducida por carcinoma ductal in situ en perras RESUMEN. En tumores mamarios, es común alteraciones inflamatorias, causadas principalmente en neoplasias que hacen metástasis. Este trabajo tiene por objetivo evaluar

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Neoplastic Disease

Salazar

2014

Canine and Feline Anesthesia and Co‐Existing Disease

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Hematologic Abnormalities in the Small Animal Cancer Patient

Cited by 48 publications

References 174 publications

Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms

Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms

Avaliação da resposta inflamatória sistêmica induzida por carcinoma ductal in situ em cadelas

Neoplastic Disease

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