Hematologic and Immunologic Evaluation of Recombinant Human Interleukin-6 in Patients with Advanced Malignant Disease: Evidence for Monocyte Activation

Keever-Taylor, Carolyn A.; Witt, Patricia L.; Truitt, Robert L.; Ramanujam, Sujatha; Borden, Ernest C.; Ritch, Paul S.

doi:10.1097/00002371-199605000-00008

Cited by 16 publications

(8 citation statements)

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“…Stimulatory effects on thrombocytopoiesis were also observed, although there was no tumor response to the IL-6 administration (16). Advanced cancer patients receiving subcutaneous injections of recombinant human IL-6 showed increased acute-phase responses throughout the treatment and increased tumor necrosis factor a. IL-6 appeared to have systemic activity on the immune system, including expansion of monocytes and activation of Th2-like cells, as well as induction of acute phase response (71). IL-6 given intravenously to adult cancer patients caused platelet counts, white blood cell counts and acute-phase protein levels to be substantially elevated, although no antitumor responses were noted (156).…”

mentioning

confidence: 99%

Acute‐phase reactants in infections and inflammatory diseases

Ebersole

Cappelli²

2000

Periodontology 2000

264

253

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mentioning

confidence: 99%

Acute‐phase reactants in infections and inflammatory diseases

Ebersole

Cappelli²

2000

Periodontology 2000

264

253

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“…1 These pro-inflammatory cytokines recruit polymorphonuclear cells, monocytes, and macrophages to the wound, which produce more pro-inflammatory cytokines and thus amplify the inflammatory response and stimulates scar formation. [2][3][4][5] Pro-inflammatory cytokines also stimulate collagen synthesis and extracellular matrix (ECM) production, and they have been implicated in other disease models of pathologic fibrosis. 1,6,7 Therefore, adult wound healing proceeds with a significant inflammatory response, which provides for rapid wound closure but also with scar formation.…”

mentioning

confidence: 99%

Modulation of the inflammatory response by increasing fetal wound size or interleukin‐10 overexpression determines wound phenotype and scar formation

Morris

Allukian

Herdrich

et al. 2014

Wound Repair Regeneration

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Wound size impacts the threshold between scarless regeneration and reparative healing in the fetus with increased inflammation showed in fetal scar formation. We hypothesized that increased fetal wound size increases pro-inflammatory and fibrotic genes with resultant inflammation and fibroplasia and that transition to scar formation could be reversed by overexpression of interleukin-10 (IL-10). To test this hypothesis, 2-mm and 8-mm dermal wounds were created in mid-gestation fetal sheep. A subset of 8-mm wounds were injected with a lentiviral vector containing the IL-10 transgene (n = 4) or vehicle (n = 4). Wounds were harvested at 3 or 30 days for histology, immunohistochemistry, analysis of gene expression by microarray, and validation with real-time polymerase chain reaction. In contrast to the scarless 2-mm wounds, 8-mm wounds showed scar formation with a differential gene expression profile, increased inflammatory cytokines, decreased CD45+ cells, and subsequent inflammation. Lentiviral-mediated overexpression of the IL-10 gene resulted in conversion to a regenerative phenotype with decreased inflammatory cytokines and regeneration of dermal architecture. In conclusion, increased fetal wounds size leads to a unique gene expression profile that promotes inflammation and leads to scar formation and furthermore, these results show the significance of attenuated inflammation and IL-10 in the transition from fibroplasia to fetal regenerative healing.

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“…IL-6 is an important multifunctional cytokine, which regulates inflammation through monocyte chemotaxis 48 and macrophage activation. 49 COX-2 is an inducible isoform of COX and is expressed under abnormal conditions such as cancer or inflammation. 50 During the process of cutaneous wound healing in rodents, COX-2 plays key role in the mechanisms underlying reepithelialization and angiogenesis, including epidermal cell migration and proliferation.…”

Section: Discussionmentioning

confidence: 99%