Hematologic and serum biochemical changes in Salmonella ser Typhimurium-infected calves

Abstract

Experimental salmonellosis of calves results in marked to severe dehydration, accompanied by metabolic acidosis, hypoglycemia, and an acute inflammatory response associated with increased fibrinogen concentrations and severe neutropenia immediately after inoculation.

Serum protein concentrations, including acute phase proteins, in calves experimentally infected with Salmonella Dublin

“…During each collection, a physical examination was performed (Dirksen et al 1993). The isolation of Salmonella Dublin was made from samples collected with rectal swabs (Rice et al 1997, Santos et al 2002. The PCR assay was also used for detection of the bacteria (Itoh et al 1997).…”

“…Although the cattle may be infected by several serovars of Salmonella, Salmonella Dublin and Salmonella Typhimurium are the most prevalent serovars isolated from calves with clinical salmonellosis (Smith et al 1989, Santos et al 2002. After oral infection, the bacteria colonize the digestive system causing cellular injury, mainly in the epithelium of the colon and ileum (Kirk et al 2002).…”

Avaliação clínica da infecção experimental de bezerros com Salmonella Dublin

“…Ao atingir a lâmina própria da parede intestinal, a Salmonella estimula uma reação inflamatória caracterizada por enterite fibrinopurulenta necrosante (Santos et al, 2002). Por serem parasitas intracelulares facultativos, as bactérias podem sobreviver e multiplicarem-se dentro de macrófagos e neutrófilos, sendo subseqüentemente transportadas aos linfonodos mesentéricos e a outros órgãos (Frost et al, 1997).…”

“…Em bezerros com um a seis semanas de idade, a infecção caracteriza-se por diarréia, desidratação, febre alta (40,5 a 42,0ºC), pneumonia, poliartrite e gangrena de extremidades (Wray e Davies, 2000;Loeb et al, 2006), sendo a taxa de mortalidade inversamente proporcional à idade (Santos et al, 2002 (2000) e Veling et al (2002). Similarmente, Yokoyama et al (1998) observaram que a maioria dos animais inoculados com Salmonella Dublin apresentaram febre a partir do segundo dia e diarréia ao terceiro dia após a infecção.…”

Efficacy of florfenicol and intravenous fluid therapy for treatment of experimental salmonellosis in newborn calves

“…Bovine salmonellosis is a disease of great relevance due to its occurrence, economical importance, and implications in public health (Santos et al, 2002;Veling et al, 2002). The serovars Salmonella Dublin and Salmonella Typhimurium are the most isolated in cattle herds, and S. Dublin is the main cattle-adapted serovar (Smith et al, 1989;Pereira et al, 2004;Silva et al, 2008a).…”