Hematologic disorders during essential hypertension

Merad-Boudia, Hamza Nadjib; Dali-Sahi, Majda; Kachekouche, Youcef; Dennouni-Medjati, Nouria

doi:10.1016/j.dsx.2019.03.011

Cited by 10 publications

(7 citation statements)

References 19 publications

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“…A cross-sectional school-based study among 6-to 16-year-old students found that higher levels of erythrocytes and hemoglobin were both associated with high blood pressure in girls or boys [14]. The different characteristics of the study populations, research designs, covariates adjusted, and different erythrocytes distribution among men and women may be partly explain the inconsistency between the present study and the two studies [8,14]. Furthermore, according to the present study, the nonlinear association between hypertension risk and level of erythrocytes may partly explain the inverse results from these previous studies.…”

Section: Discussioncontrasting

confidence: 79%

“…The association between erythrocytes, hemoglobin with hypertension risk could have been biased due to the loss to follow-up. Moreover, other erythrocytes parameters, such as hematocrit (index for quantitative measures of erythrocytes), red cell distribution width, deformability of erythrocytes, and hemoglobin variability, which could be involved in the pathogenesis of hypertension [8,21,25–29], were not available in the present study, limiting a more extensive evaluation of erythrocytes in association with the hypertension risk.…”

Section: Discussionmentioning

confidence: 99%

“…Decreased erythrocytes or hemoglobin in mammals were reported to be related to the reduction of systemic blood pressure through regulation of hypotensive factor, such as peripheral vasodilation, cardiac exhaustion, and low blood viscosity [6,7]. However, other studies showed that levels of erythrocytes were negatively associated with risk of developing hypertension, and anemic patients had a higher proportion of hypertension compared with nonanemic population [8,9]. Whether erythrocytes and hemoglobin are associated with hypertension is still poorly understood and evidence based on large-scale cohort studies is lacking.…”

Section: Introductionmentioning

confidence: 99%

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Gender differences in the associations of circulating erythrocytes and hemoglobin with hypertension risk

Liu

Wang²,

Zhang³

et al. 2022

Blood Pressure Monitoring

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Objective Studies on associations of erythrocytes parameters with hypertension risk are scarce. We aimed to examine associations of the erythrocytes parameters with the hypertension risk and potential effect modification by gender using data from the China Health and Nutrition Survey. Methods A total of 5419 eligible participants (2468 men, 45.5%) without hypertension at baseline in 2009 were included and followed for a median of 6.1 years. Parameters of erythrocytes and hemoglobin were measured at baseline. Multivariable Cox proportional hazards models were used to estimate the hazard ratio for the associations between these parameters and hypertension risk. Data were collected from 2009 to 2015 and analyzed in 2021. Results A total of 1178 incident cases of hypertension were identified during the follow-up. In women, erythrocytes and hemoglobin were positively associated with risk of hypertension, yielding the highest hazard ratio in the third quartile of 1.59 (95% confidence interval, 1.28–1.97, P trend < 0.001) for erythrocytes and in the fourth quartile of 1.64 (95% confidence interval, 1.23–2.17, P trend < 0.001) for hemoglobin compared with their first quartile, respectively. In addition, quartiles of erythrocytes and hemoglobin were not associated with risk of hypertension in men (P trend > 0.050). Conclusion Erythrocytes and hemoglobin were associated with an increased risk of hypertension in women, but not in men. Our findings suggest that special attention for the prevention of hypertension should be given to those women with the moderate to high level of circulating erythrocytes and higher level of hemoglobin.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gender differences in the associations of circulating erythrocytes and hemoglobin with hypertension risk

Liu

Wang²,

Zhang³

et al. 2022

Blood Pressure Monitoring

View full text Add to dashboard Cite

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“…Possible biological plausibility of the divergent association between height and SBP among females is that the calibre of coronary arteries in females is smaller than males which might increase the risk of having higher SBP among females [ 15 ]. However, studies from other part of the world found the divergent association between height and SBP in both males and females, but showed that the dose dependent relationship is much stronger in females compare to males [ 7 , 8 , 19 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of height on blood pressure and hypertension among Bangladeshi adults

Islam

Siraj

Hassan

et al. 2020

International Journal of Cardiology Hypertension

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“…It causes an increase in WBC count, a decrease in red cell deformability and an increase in platelet activation [7][8][9]. This alteration may worsen in the microcirculation and enhance an end-organ damage [10].…”

Section: Introductionmentioning

confidence: 99%

A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia

2021

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Background Hypertension is the major public health concern; leading to cardiovascular disease. It is associated with alteration in hematological parameters which may lead to end-organ damage. Thus, this study aimed to compare hematological parameters between hypertensive and normotensive adult groups in Harar, eastern Ethiopia. Methods A comparative cross-sectional study was conducted from January to March, 2020 at Jugel and Hiwotfana Specialized University hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from the two hospitals and 102 apparently healthy blood donors. Participant’s socio-demographic and clinical information were collected using pre-tested structured questionnaire. Blood sample were collected and analyzed by Beckman Coulter DxH 500 analyzer for complete blood count. The data were entered and analyzed using SPSS version 23. Independent t-test and Mann Whitney u-test was used for comparison between groups. Spearman’s correlation was used for correlation test. P values less than 0.05 was considered as statistically significant. Result 102 hypertensive and 102 healthy controls were enrolled in this study. The median ± IQR value of white blood cell (WBC) count, hemoglobin (Hgb), hematocrit (HCT), red cell distribution width (RDW) and mean platelet volume (MPV) were significantly higher in hypertensive group compared to apparently healthy control group. Additionally, RBC (red blood cell) count, HCT and RDW showed statistically significant positive correlations with systolic and diastolic blood pressure. WBC count and RDW were significantly and positively correlated with body mass index (BMI). Platelet (PLT) count had a significant but negative correlation (r = -0.219, P = 0.027) with duration of hypertension illness while MPV showed positive and significant correlation (r = 0.255, P = 0.010). Conclusion The median values of WBC, Hgb, HCT, RDW and MPV were significantly higher in hypertensive patient compared to apparently healthy individuals. Hence, it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated with hematological aberrations. However, further studies are required to understand hypertensive associated changes in hematological parameters.

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Hematologic disorders during essential hypertension

Cited by 10 publications

References 19 publications

Gender differences in the associations of circulating erythrocytes and hemoglobin with hypertension risk

Gender differences in the associations of circulating erythrocytes and hemoglobin with hypertension risk

Influence of height on blood pressure and hypertension among Bangladeshi adults

A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia

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