Hematologic, lipid profile, immunity, and antioxidant status of growing rabbits fed black seed as natural antioxidants

El-Gindy, Yassmine M.; Zeweil, H. S.; Zahran, Soliman Mohamed; El-Rahman, Mohamed Abd; Eisa, Fawzi

doi:10.1007/s11250-019-02091-x

Cited by 16 publications

(35 citation statements)

References 15 publications

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“…The administration of NSSE and NSO to diabetic rabbits significantly (p<0.001) increased the mean body weight as compared to diabetic group. The results match with the results reported by (Akhtar et al, 2020;Chisom et al, 2022;El-Gindy et al, 2020).…”

Section: Proximate and Mineral Analysis Of Plant Seed Powderssupporting

confidence: 92%

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2022

Pak. J. Pharm. Sci.,

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The present study was aimed to investigate the comparative antidiabetic potential of Nigella sativa seed extract and oil in an in vivo trial using rat animal model. The levels of antioxidants analysed in this study included catalase, vitamin C and bilirubin. NS methanolic extract and its oil were tested for their hypoglycemic effect against alloxanized diabetic rabbits (120mg/kg). The crude methanolic extract and the oil (2.5ml/kg/day) were given orally for 24 days that resulted in a significant reduction in glycaemia, particularly during the first 12 days of treatment (reductions of 58.09% and 73.27%, respectively), whereas the oil treated group normalised the levels of catalase (-69.23%), vitamin C (27.30%), and bilirubin (-51.48%) and the extract treated group normalised the levels of catalase (-65.38), vitamin C (24.15%), and bilirubin (-26.19%) at the end of the trial. The results have shown that the seed oil more significantly normalized the levels of serum catalase, serum ascorbic acid, and total serum bilirubin as compared to the methanolic extract of Nigella sativa, so Nigella sativa seed oil (NSO) may be used as part of antidiabetic remedies against diabetes and utilized as a nutraceutical.

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Section: Proximate and Mineral Analysis Of Plant Seed Powderssupporting

confidence: 92%

Untitled

2022

Pak. J. Pharm. Sci.,

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“…40 Furthermore, Palazzo et al 41 observed no differences in body weight gain of rabbits fed a diet supplemented with Lippia citriodora extract. However, dietary inclusion of Nigella sativa seed improved feed efficiency and body weight gain in rabbits, 42 whereas the supplementation of Camellia sinensis powder reduced body weight gain in rabbits. 43 The carcass traits and the relative weight of internal organs in rabbits supplemented with ACS are presented in Table 3.…”

Section: Resultsmentioning

confidence: 98%

“…observed no differences in body weight gain of rabbits fed a diet supplemented with Lippia citriodora extract. However, dietary inclusion of Nigella sativa seed improved feed efficiency and body weight gain in rabbits, 42 whereas the supplementation of Camellia sinensis powder reduced body weight gain in rabbits 43 …”

Section: Resultsmentioning

confidence: 99%

Dietary supplementation of Allium cepa skin alters intramuscular fat, muscle cholesterol, and fatty acids in rabbits

2021

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BACKGROUND:The high polyunsaturated fatty acids content of rabbit meat predisposes it to oxidative deterioration, which often results in reduced product quality and shelf life. This fact highlights the need to improve the antioxidant status of rabbit meat. This study investigated the effects of dietary supplementation of Allium cepa skin (ACS) on growth, carcass, intramuscular fat, muscle fatty acids, cholesterol content, meat quality, antioxidant status, and sensory attributes of hind leg muscle of rabbits. Sixty-three, 28-day-old, male New Zealand rabbits (654 ± 25 g) were randomly allocated into 21 pens of three rabbits. The pens were randomly assigned to one of three dietary treatments -ACS-0: basal diet (BD) only; ACS-25: BD + 25 g kg −1 ACS; and ACS-50: BD + 50 g kg −1 ACSfor 56 days and then euthanized. RESULTS: Dietary ACS did not affect growth performance and retail cuts of rabbits. Muscle cholesterol was lower (P < 0.05) in ACSsupplemented rabbits than in controls. Dietary ACS lowered (P < 0.05) dissectible fat, intramuscular fat content, C14:0, C16:0, C18:0, C18:2n−6, and C20:4n−6 levels and enhanced (P < 0.05) C18:3n−3, C20:5n−3, C22:6n−3, and C22:5n−3 concentration. Dietary ACS increased muscle catalase activity in rabbits. Sensory qualities, malondialdehyde and carbonyl contents, and physicochemical attributes of hind leg muscle of rabbits after chill storage were not influenced by dietary ACS supplementation. CONCLUSION: Supplementation with 50 g kg −1 ACS reduced intramuscular fat and cholesterol content and improved muscle n−3 fatty acids without impairing the physicochemical and sensory properties of rabbit meat.

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“…Similarly, TQ elevates SOD, CAT, and GSH levels, upregulates antioxidant genes, and downregulates prooxidant genes [44]. Another study in rabbits revealed that consuming black cumin seeds (600 mg/kg) decreased MDA and increased total antioxidant levels in the blood [45]. Again, combined supplementation of TQ and NSO exhibited antioxidant capabilities against cisplatin (CP)-induced abnormalities [46].…”

Section: Antioxidant and Anti-inflammatory Effects Of Black Cumin And Tqmentioning

confidence: 99%

Protective Effects of Black Cumin (Nigella sativa) and Its Bioactive Constituent, Thymoquinone against Kidney Injury: An Aspect on Pharmacological Insights

Hannan

Zahan²,

Sarker³

et al. 2021

IJMS

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The prevalence of chronic kidney disease (CKD) is increasing worldwide, and a close association between acute kidney injury (AKI) and CKD has recently been identified. Black cumin (Nigella sativa) has been shown to be effective in treating various kidney diseases. Accumulating evidence shows that black cumin and its vital compound, thymoquinone (TQ), can protect against kidney injury caused by various xenobiotics, namely chemotherapeutic agents, heavy metals, pesticides, and other environmental chemicals. Black cumin can also protect the kidneys from ischemic shock. The mechanisms underlying the kidney protective potential of black cumin and TQ include antioxidation, anti-inflammation, anti-apoptosis, and antifibrosis which are manifested in their regulatory role in the antioxidant defense system, NF-κB signaling, caspase pathways, and TGF-β signaling. In clinical trials, black seed oil was shown to normalize blood and urine parameters and improve disease outcomes in advanced CKD patients. While black cumin and its products have shown promising kidney protective effects, information on nanoparticle-guided targeted delivery into kidney is still lacking. Moreover, the clinical evidence on this natural product is not sufficient to recommend it to CKD patients. This review provides insightful information on the pharmacological benefits of black cumin and TQ against kidney damage.

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Hematologic, lipid profile, immunity, and antioxidant status of growing rabbits fed black seed as natural antioxidants

Cited by 16 publications

References 15 publications

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Dietary supplementation of Allium cepa skin alters intramuscular fat, muscle cholesterol, and fatty acids in rabbits

Protective Effects of Black Cumin (Nigella sativa) and Its Bioactive Constituent, Thymoquinone against Kidney Injury: An Aspect on Pharmacological Insights

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