Hematological abnormalities among adults with type 1 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital

Getawa, Solomon; Adane, Tiruneh

doi:10.1177/20503121221094212

Cited by 4 publications

(4 citation statements)

References 50 publications

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“…Complete blood count (CBC), fasting blood glucose levels (FBG), post prandial blood glucose levels (PPBG), glycated hemoglobin levels (HbA1C), ESR, liver functions tests, and renal functions tests were assessed for all subjects as described before. 11,12 Detection of IFNλ-4 rs73555604 and ERAP rs26618 polymorphisms…”

Section: Hematological and Biochemical Investigationsmentioning

confidence: 99%

Genetic polymorphisms of Endoplasmic reticulum amino peptidase 1 (ERAP1) and Interferon lambda 4 (IFN-λ4) in Egyptian patients with type 1 diabetes mellitus

Nazar¹,

Ghazy²,

Amer³

et al. 2023

EJI

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Different genetic and environmental factors are implicated in type I diabetes (T1DM) pathogenesis. About 50% of the genetic susceptibility for T1DM is related to human leukocyte antigen (HLA) genes. Other non-HLA genes have variable roles in the destruction of pancreatic β cells. A highly variable gene called endoplasmic reticulum associated with antigen processing gene 1(ERAP1) shares in activating autoreactive CD8+ T lymphocytes, peptide trimming, and subsequent pancreatic β cells destruction. Local production of inflammatory cytokines within the cells of islets of Langerhans is linked to T1DM progression. Different viral and autoimmune disorders have been linked to genetic variations in type III interferon (IFNλs). This study aimed to determine genetic polymorphisms of interferon lambda 4 (IFNλ4rs 73555604) and endoplasmic reticulum aminopeptidases 1 (ERAP1 rs26618) in Egyptian patients with T1DM. The study recruited 120 patients with T1DM from Kafrelsheikh University Hospital and 100 normal controls who were age and sex matched with the patients’ group. Single-nucleotide polymorphism (SNP) genotyping of ERAP1(rs26618) and IFN-λ-4(rs73555604) was performed using real-time polymerase chain reaction. Patients with CC genotype were less likely to develop T1DM than those with TC and TT genotypes for both genes. In addition, T allele frequency in comparison to C allele frequency was significantly increased in T1DM patients when compared to control group (p<0.001). There were positive correlations between studied SNPs for both genes, fasting and postprandial blood glucose levels which suggest the association of these genes with T1DM occurrence. We concluded that the studied SNPs of ERAP1gene (rs26618) and IFNλ-4 gene(rs73555604) may be associated with T1DM development. In addition, T alleles for both genes could be considered risk alleles while C alleles would be regarded as a protective allele. Patients with TC and TT genotypes would be at a higher risk for T1DM than those carrying CC genotype.

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Section: Hematological and Biochemical Investigationsmentioning

confidence: 99%

Genetic polymorphisms of Endoplasmic reticulum amino peptidase 1 (ERAP1) and Interferon lambda 4 (IFN-λ4) in Egyptian patients with type 1 diabetes mellitus

Nazar¹,

Ghazy²,

Amer³

et al. 2023

EJI

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show abstract

“…Acute complications include symptoms such as hypoglycemia, hyperglycemic crises, hyperglycemic hyperosmolar state and diabetes ketoacidosis. Chronic complications include diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, microvascular complications, and haematological abnormalities (Lim, 2014;Nentwich and Ulbig, 2015;Chawla et al, 2016;Okonofua et al, 2021;Getawa and Adane, 2022;Okonofua et al, 2023).…”

Section: Complications Of Diabetes Mellitusmentioning

confidence: 99%

Coexistence of hypertension with diabetes mellitus and its pharmacotherapy

Moke,

Demaki,

Daubry

et al. 2023

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Diabetes mellitus and hypertension are common comorbidities, as hypertension is reported to be twice as frequent in diabetic patients as people who are non- diabetics. In diabetic condition, the risk and progression of cardiac disease, peripheral vascular disease, stroke, retinopathy, and nephropathy is greatly increased in the presence of hypertension. Persistent increase in blood pressure termed hypertension, can be either primary hypertension (essential hypertension) or secondary hypertension in nature. Primary or essential hypertension is characterized by elevated blood pressure caused by inherited factors which are characteristic of essential hypertension whereas identifiable causes such as chronic kidney diseases, endocrine disorders, constriction of the kidney arteries, or the use of drugs are among the etiology of secondary hypertension. Diabetes causes hyperinsulinemia which increases the risk of hypertension. This condition increases the amount of sodium that the body absorbs. It also promotes the stimulation of the sympathetic nervous system. Treatment of both conditions is crucial as they are considered risk factors for coronary artery disease, cerebrovascular disease, renal failure and congestive heart failure. In any age group, a considerable increase in systolic blood pressure causes a significant increase in cardiovascular disease. To achieve sufficient blood pressure control, most people with hypertension and diabetes require more than one medication. This review is aimed to discuss hypertension and diabetes mellitus comorbidities and their treatment.

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“…In this regard, studies indicated that BMI, waist circumference (WC), and waist-to-hip ratio (WHR) anthropometric index are comparable in predicting diabetes onset and following complications [ 9 , 10 ]. Moreover, patients with diabetes usually illustrated abnormalities in their laboratory findings [ 11 , 12 ]. The WHR associated with fasting blood sugar (FBS) levels, proteomic profile, and lipid profiles reflect its role in assessing metabolic health.…”

Section: Introductionmentioning

confidence: 99%

The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population

Aghaei,

Joukar,

Hasanipour

et al. 2024

BMC Endocr Disord

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Background Waist circumference (WC), or waist-to-hip ratio (WHR), potentially offers a more accurate reflection of intra-abdominal fat accumulation and could serve as a superior predictor of type 2 diabetes mellitus (T2DM) risk compared to BMI. The current study investigated the relationship between WHR and its influencing factors among diabetes patients enrolled in the Prospective Epidemiological Research Studies in Iran (PERSIAN) Guilan Cohort study (PGCS). Method In this cross-sectional study of 10,520 participants, 2,531 had T2DM. Waist and hip circumference, body mass index (BMI), underlying diseases, and demographical data of participants were recorded. Also, fasting blood sugar (FBS), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides (TG) were assessed. All data was analyzed using SPSS version 16; the significant level was < 0.05. Results The mean age of participants was 51.52 ± 8.90 years, and 39.9% had a BMI between 25 and 30 kg/m2. The prevalence of diabetes was 24.1% (n = 2531). About 7628 (72.5%) individuals had abnormal WHR, and 2072 (19.7%) were diabetics. Among patients with diabetes, abnormal WHR was significantly associated with age over 50, female gender, higher BMI, and lower LDL (P < 0.05). Conclusion The study showed a higher prevalence of abnormal WHR in diabetic patients. Abnormal WHR in patients with diabetes was significantly associated with age, gender, and BMI.

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Hematological abnormalities among adults with type 1 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital

Cited by 4 publications

References 50 publications

Genetic polymorphisms of Endoplasmic reticulum amino peptidase 1 (ERAP1) and Interferon lambda 4 (IFN-λ4) in Egyptian patients with type 1 diabetes mellitus

Genetic polymorphisms of Endoplasmic reticulum amino peptidase 1 (ERAP1) and Interferon lambda 4 (IFN-λ4) in Egyptian patients with type 1 diabetes mellitus

Coexistence of hypertension with diabetes mellitus and its pharmacotherapy

The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population

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