Hematological Changes in an Ovine Model of Acute Myocardial Infarction

Fathi, Ezzatollah; Farahzadi, Raheleh; Pishgahzadeh, Elaheh

doi:10.5296/jbls.v4i2.3648

Cited by 2 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sheep have been commonly used as an animal model for many cardiovascular studies. 6,8 In this study, we evaluated the usefulness of scar size in combination with selected parameters to track the progression of left ventricular myocardial disease. Daily routine clinical evaluation of the animals was uninformative in the assessment of the onset and progression of disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Scar Size and Other Parameters for Tracking Left Ventricular Dysfunction after Induction of Myocardial Infarcts in Sheep (Ovis aries)

et al. 2018

View full text Add to dashboard Cite

In humans, cardiovascular disease (CVD) is the most frequent cause of death worldwide. Myocardial infarction (MI) is a leading cause of heart failure due to myocardial impairment, yet the progression of the resultant dysfunction is often undetected after incidental or induced myocardial infarction. In this study we tracked the progression of left-sided heart failure in 6-mo-old male castrated sheep in which we created 2 models of myocardial infarction, small and large. Myocardial infarction was induced through ligation of a single branch (obtuse marginal [OM] 1) of the left circumflex coronary artery to create small (mild) infarcts and of 2 branches (OM1 and OM2) for large (severe) infarcts. Progression of heart failure was evaluated by assessing scar size, the left ventricular ejection fraction, hematology, cardiac serum biochemical biomarkers, ST elevation, and clinical observation. All parameters were assessed at baseline and at 3 wk and 3 mo after infarction, except that clinical observation of the animals was conducted daily. The different parameters differed in their usefulness: some verified appropriate creation of the model, whereas others enabled assessment of the progression of heart disease. We hypothesize that myocardial scar size, as a function of induced ischemia, coupled with left ventricular ejection fraction are predictive indicators of postinfarction cardiac dysfunction.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In addition, the sheep heart is similar to that of humans both in terms of size and the composition of cardiomyocytes. 5,6,18 The current study provides valuable insights regarding the use of infarction scar size in conjunction with left ventricular ejection fraction as a useful predictor of advanced left ventricular dysfunction.…”

mentioning

confidence: 98%

Scar Size and Other Parameters for Tracking Left Ventricular Dysfunction after Induction of Myocardial Infarcts in Sheep (Ovis aries)

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Still, the specific effects on immunogenic and vascular gene expressions and gross and microscopic parameters remain relatively unexplored. The past decade has seen increased human health hazards linked to uncontrolled smartphone use (Fathi & Farahzadi, 2014). Human bodies absorb radiation, converted into electric and magnetic fields, altering the structure of cells, the plasma membrane and receptors for various biomolecules during embryonic development (Al‐Qudsi & Azzouz, 2012; Bhat, 2013).…”

Section: Introductionmentioning

confidence: 99%

4G mobile phone radiation alters some immunogenic and vascular gene expressions, and gross and microscopic and biochemical parameters in the chick embryo model

Islam,

Rahman

et al. 2023

Veterinary Medicine & Sci

View full text Add to dashboard Cite

BackgroundThe risks to human health have grown over the past 10 years due to the excessive use of mobile phones.ObjectivesThe study was designed to determine the harmful effects of 4G mobile phone radiation on the expression of immunogenic and vascular genes and gross, microscopic and biochemical alterations in the development of chicken embryos.MethodsSixty individuals in the exposure group were subjected to mobile phones with a specific absorption rate of 1.4 W/kg and a frequency of 2100 MHz positioned at a distance of 12 cm in the incubator for 60 min/night for 14 days. The histopathological examination involved hematoxylin and eosin staining, whereas cresyl violet staining was used to evaluate the condition and number of neurons in the brain. The biochemical parameters of amniotic fluid were analysed using the photometry method, and the expression of VEGF‐A and immunity genes (AvBD9, IL6) was measured using the real‐time PCR (qPCR) technique.ResultsCompared to the control, the exposure group's body weight and length significantly decreased (p < 0.05). Subcutaneous bleeding was seen in the exposure group. Urea, creatinine, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase levels were all significantly higher than in the control group (p < 0.05). The exposed group showed pathological lesions in the liver and degenerated neurons with lightly stained nuclei in the cerebral cortex. Hyperchromatic neurons were significantly higher in the exposure group (58.8 ± 2.28) compared to the control (6.6 ± 0.44) (p < 0.05). 4G exposure reduced lymphocyte count in the caecal tonsil (86.8 ± 5.38) compared to the control (147.2 ± 9.06) (p < 0.05). Vascular gene mRNA expression was higher, but immune gene expression was lower in the exposed group.ConclusionExposure to mobile phone radiation may result in gross, microscopic and biochemical changes, as well as alterations in gene expression that could hinder embryonic development.

show abstract

Hematological Changes in an Ovine Model of Acute Myocardial Infarction

Cited by 2 publications

References 44 publications

Scar Size and Other Parameters for Tracking Left Ventricular Dysfunction after Induction of Myocardial Infarcts in Sheep (Ovis aries)

Scar Size and Other Parameters for Tracking Left Ventricular Dysfunction after Induction of Myocardial Infarcts in Sheep (Ovis aries)

4G mobile phone radiation alters some immunogenic and vascular gene expressions, and gross and microscopic and biochemical parameters in the chick embryo model

Contact Info

Product

Resources

About