Hematological changes in psoriasis. Secondary anemia, XVIII

Molin, L; Reizenstein, Peter

doi:10.2340/0001555554465469

Cited by 12 publications

(3 citation statements)

References 6 publications

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“…If the scaling occurs ovcr a considerable period or time, however, the loss or iron via scaling in widespread psoriasis may be sufficient to result in iron deficiency. In most cases of psoriasis, howevcr, the anemia found is not of iron-deficiency type but of chronic simple type (10).…”

Section: Resultsmentioning

confidence: 97%

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Iron content in normal and psoriatic epidermis

Molin¹,

Po²

1973

Acta Derm Venereol

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Section: Resultsmentioning

confidence: 97%

“…Anemia has been demonstrated in subjects suffering from psoriasis, not only in the more extensive conditions of the disease (14) hut even in its milder Forms. There is a relationship be tween the degree of anemia and the extent of the psoriatic Jesions (10).…”

mentioning

confidence: 99%

Iron content in normal and psoriatic epidermis

Molin¹,

Po²

1973

Acta Derm Venereol

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“…Current evidence that macrophages are altered in psoriatic subjects is indirect. Molin & Reizenstein (7) reported enhanced uptake of radioactively labelled red blood cells by the reticuloendothelial system. We have attempted to study macrophages grown from circulating psoriatic monocytes to see if the hyperactivity of psoriatic neutro phils and blood monocytes also occurs in these cells.…”

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confidence: 99%

Increased macrophage activity in psoriasis

Koh,

Majewski,

Rhodes

1985

Acta Derm Venereol

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Deranged iron status in psoriasis: the impact of low body mass

Ponikowska

Tupikowska

Kasztura

et al. 2015

Journal of Cachexia, Sarcopenia and Muscle

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BackgroundIron deficiency (ID) frequently complicates inflammatory-mediated chronic disorders, irrespective of anaemia. Psoriasis is a chronic, immune-mediated skin disease with systemic pro-inflammatory activation; thus, these patients may be prone to develop ID. ID adversely affects immune cells function, which can further contribute to disease progression. This study investigates iron status in psoriasis.MethodsSerum concentrations of ferritin, transferrin saturation (Tsat), soluble transferrin receptor (sTfR), and hepcidin were assessed as the biomarkers of iron status in 39 patients with psoriasis (17 men, age: 47 ± 10 years) and 44 healthy subjects (30 men, age: 53 ± 6 years).ResultsCompared with healthy controls, patients with psoriasis demonstrated similar haematologic status but deranged iron status as evidenced by decreased Tsat and elevated sTfR (negative tissue iron balance) and low levels of hepcidin (depleted iron stores) (all P < 0.05 vs. controls). In patients, the levels of interleukin-6 (level of pro-inflammatory activation) significantly correlated with hepcidin (R = 0.54), but not with ferritin, Tsat, and sTfR. Biomarkers reflecting ID were not associated with the severity of the disease (assessed with the Psoriasis Area and Severity Index) but significantly correlated low body mass index (BMI). Patients with BMI < 24 kg/m2 compared with those with BMI ≥ 24 kg/m2 demonstrated lower levels of ferritin (40 ± 30 vs. 186 ± 128 ng/mL, P < 0.001) and hepcidin (4.9 ± 2.3 vs. 10.7 ± 6.7 ng/mL, P = 0.03).ConclusionPsoriasis is associated with deranged iron status characterized by depleted iron stores with concomitant unmet cellular iron requirements. The magnitude of these abnormalities is particularly strong in patients with low body mass index. Whether iron deficiency may become a therapeutic target in psoriasis needs to be investigated.

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Hematological changes in psoriasis. Secondary anemia, XVIII

Abstract: is not availeble.

Cited by 12 publications

References 6 publications

Iron content in normal and psoriatic epidermis

Iron content in normal and psoriatic epidermis

Increased macrophage activity in psoriasis

Deranged iron status in psoriasis: the impact of low body mass

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