Hematological parameters in sick cell anemia patients with and without priapism

Ahmed, Sagir G.; Ibrahim, Umma A.; ., A.W. Hassan

doi:10.5144/0256-4947.2006.439

Cited by 23 publications

(24 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The finding of elevated WBC counts in SCA patients with and without TB was consistent with earlier studies, which showed that leucocytosis was a common feature of SCA even in steady state in the absence of infections and was thought to be due to redistribution of granulocytes from marginal to circulating pool 16,17. However, our data revealed significantly higher mean WBC count among SCA patients with TB.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria.

Ahmed

Bukar²,

Jolayemi³

2010

Mediterr J Hematol Infect Dis

Self Cite

View full text Add to dashboard Cite

Nigeria has the fourth highest prevalence of TB and the highest prevalence of Sickle cell anaemia (SCA) in the world. SCA patients have impaired immunity and are vulnerable to TB. Hence, we studied the haematological indices of SCA patients with TB in Nigeria. A total of 23 SCA patients with TB were studied in parallel with equal number of age and sex matched SCA patients without TB. SCA patients with TB had significantly lower haematocrit, higher level of circulating sickle cells (CSCs) and similar level of reticulocyte count in comparison to patients without TB. SCA patients with TB had significantly higher mean WBC count associated with higher frequency of neutrophilia in comparison to those without TB. Monocytosis and eosinopenia were exclusively found in SCA patients with TB at frequencies of 52% and 65% respectively. Lymphocyte and basophil counts were normal in all patients with and without TB. Mean platelet counts were high in both patient groups but the frequency of thrombocytosis was significantly higher in patients with TB. SCA patients with TB had significantly higher mean ESR than their counterparts without the infection. The findings of this study revealed that TB in SCA patients was associated with rising level of CSCs, falling level of haematocrit, sub-optimal reticulocytosis, neutrophilia, monocytosis, thrombocytosis, eosinopenia and rising level of ESR. Hence, SCA patients presenting with these haematological indices should be investigated for TB.

show abstract

Section: Discussionsupporting

confidence: 92%

“…Thrombocytosis in SCA patients was attributed to the background haemolytic anaemia and autosplenectomy 17,22. However, our data revealed that SCA patients with TB had higher frequency of thrombocytosis and significantly higher mean platelet count than their counterparts without TB.…”

Section: Discussionmentioning

confidence: 99%

Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria.

Ahmed

Bukar²,

Jolayemi³

2010

Mediterr J Hematol Infect Dis

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nolan et al [ 2 ] reported a positive relationship between priapism and a low Hb concentration as well as high platelet counts, serum AST and bilirubin, but this was not confirmed in our study. The study by Ahmed et al [ 18 ] reported a higher Hb concentration in HbSS patients who had priapism compared to those who did not. There was no significant difference in the Hb concentration of the 2 groups in our study, and this may be partly explained by variations in environmental as well as dietary or other genetic factors which may play an important part in the occurrence of priapism found in SCD.…”

Section: Discussionmentioning

confidence: 99%

Priapism in Homozygous Sickle Cell Patients: Important Clinical and Laboratory Associations

Madu¹,

Ubesie

Ocheni³

et al. 2014

Med Princ Pract

View full text Add to dashboard Cite

Objective: To evaluate the relationship between the occurrence of priapism and important steady-state clinical and laboratory parameters in homozygous sickle cell disease (SCD). Subjects and Methods: Steady-state clinical and laboratory data were obtained from the medical records of 126 male patients seen in the clinic over a 7-year period. Estimated prevalence rates, correlation coefficients and independent t tests were calculated to assess the relationship between priapism and several important clinical and laboratory indices. Patient data on age, haemoglobin concentrations, the frequency of crises per annum, leucocyte counts, platelet counts, serum bilirubin and aspartate transaminase were evaluated. Results: The prevalence of priapism was determined to be 21.4%, and 22.2% of those affected had erectile dysfunction. There was a significant positive correlation between priapism and older age (p = 0.049) and lower leucocyte counts (p = 0.008). There was no significant relationship with other clinical or laboratory indices. Conclusion: About 1 in 4 of all homozygous older SCD patients had priapism, and an approximately similar ratio developed erectile dysfunction; they also had lower steady-state leucocyte counts. Other clinical and laboratory indicators of disease severity in SCD did not positively correlate with the occurrence of priapism, and this may imply an alternative pathogenetic mechanism.

show abstract

“…In two other smaller series comprising 18 and 23 male patients with sickle cell anaemia and a reported history of priapism, study subjects had a higher haematocrit, blood viscosity (Ahmed et al, 2006) and haemoglobin value (Adedeji et al, 1988) compared to age-matched counterparts without this complication.…”

Section: Identification Of Individuals At Risk Of Priapismmentioning

confidence: 98%

How I manage priapism due to sickle cell disease

Olujohungbe

Burnett

2013

Br J Haematol

View full text Add to dashboard Cite

SummaryPriapism due to sickle cell disease is a common but less well characterized complication of the disorder. It represents a "medical emergency" with the key determinant of outcome being the duration of penile ischaemia and time to detumescence of <4 h associated with a successful treatment outcome. Management can be outpatient-based and consists of pre-emptive strategies for early stuttering attacks based on prior health education of the association between the 2 disorders, non pharmacological management, outpatient penile aspiration and irrigation with or without instillation of alpha and beta adrenergic agonists for acute episodes and secondary prophylaxis to prevent the high rates of recurrences. The evidence to recommend medical prophylaxis is sparse but based on a consensus of experts and small phase 2 or III clinical trials. A clearer understanding of the molecular mechanism(s) involving normal and dysregulated erectile physiology, scavenger haemolysis and nitric oxide pathway paves way for the use of phosphodiesterase type 5 inhibitors in medical prophylaxis of stuttering attacks. These agents will need to be studied in multi-centre randomized phase III trials before they become standard of care. A multidisciplinary team approach is required to enhance "sexual wellness" and prevent erectile dysfunction in this sexually vulnerable group.

show abstract

Hematological parameters in sick cell anemia patients with and without priapism

Cited by 23 publications

References 26 publications

Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria.

Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria.

Priapism in Homozygous Sickle Cell Patients: Important Clinical and Laboratory Associations

How I manage priapism due to sickle cell disease

Contact Info

Product

Resources

About