Hematological Study on Pulmonary Tuberculosis (PTB) Predominance in Quetta.

Hameed, Tahir; Yousaf, Maryam; Abbas, Farhat; Rafiq, A; Khan, Anum; Iqbal, Qandeel; Ali, Modisa Mashhad; Khan, Shees; Rauf, Abdul

doi:10.31580/pjmls.v2i2.966

Cited by 3 publications

(3 citation statements)

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“…20 Pakistan, being a developing nation, is fighting against malnutrition which is a complex, multisectoral issue and has a bidirectional relationship with tuberculosis. 21,22 Khalid et al reported that TB patients in Pakistan were twice as likely to be malnourished than the healthy group. 23 TB group patients of the current study belonged to low socio-economic 3: Perception about TB treatment status and therefore might be malnourished as well as, we did not evaluate the physical status of the participants.…”

Section: Discussionmentioning

confidence: 99%

An Investigation into Implications of Tuberculosis Control Efforts in Pakistan: A Comparative Approach

Qureshi,

Faiz,

Khalid

2023

J. Bahria Uni. Med. Dent. Coll.

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Objective: To investigate the difference of Tuberculosis (TB) related information in diagnosed TB patients and healthy individuals in relation to the implications of National Tuberculosis Program (NTP) control efforts. Study Design and Setting: This comparative case-control study was conducted from May to December 2022 in public sector tertiary care setups of Karachi. Methodology: In this case control study, 100 hospitalized diagnosed patients of TB were compared with 155 healthy individuals from May to December 2022. We analyzed sociodemographic characteristics of both groups related to the information for transmission and prevention of TB, as a basic element for the disease control. Result: TB patients were more likely to be uneducated, have low household income and positive family history of TB as compared to non-TB (OR 0.52, 0.30, 0.40). 18% of TB patients believed that TB infected person cannot be a source of spread to cause TB disease (OR=4.7; P=0.006). There was a statistically significant association among both the groups deemed to malnutrition and multiple households as the risk factors of tuberculosis (P=0.002 and <0.001 respectively Conclusion: TB related information with respect to its cause, preventive and treatment was insufficient in both study groups leading to delay in TB treatment and increase mortality from the disease. Health education interventional strategies, focused on primitive and advanced TB related information are needed in general population with special attention on low socioeconomic groups of community, and the population living in isolated and remote areas.

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Section: Discussionmentioning

confidence: 99%

An Investigation into Implications of Tuberculosis Control Efforts in Pakistan: A Comparative Approach

Qureshi,

Faiz,

Khalid

2023

J. Bahria Uni. Med. Dent. Coll.

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“…14 But no previous studies in Pakistan showed this association. 5,6,12 More studies are needed to confirm this trend of thrombocytosis in TB patients.…”

Section: A H E a D O F P R I N Tmentioning

confidence: 99%

“…3 The spread of this disease is caused by several factors notably Email: dryasmeenbatool@gmail.com the HIV/AIDS epidemic, low socio-economic status, overcrowding and malnutrition. [4][5][6] A study in Karachi provides evidence for a strong positive association between tuberculosis and diabetes. 7 A study in Jamshoro detected primary multi drug resistant tuberculosis more commonly in previously diagnosed and treated patients but also in newly diagnosed pulmonary patients and its due to dissemination of MDR cases within the community, difficult to treat.…”

Section: Introductionmentioning

confidence: 99%

Hematological manifestations in patients newly diagnosed with pulmonary tuberculosis

Batool¹,

Na²,

Na³

et al. 2022

Pak J Med Sci

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Objective: To determine the frequency of various hematological manifestations among newly diagnosed cases of pulmonary tuberculosis on complete blood counts. Methods: This retrospective cross-sectional study was conducted on 500 newly diagnosed patients of pulmonary tuberculosis in hematology department of Nishtar Medical University from 1st November 2020 to 30th April 2021 using consecutive sampling. Detailed history and complete general physical examination findings, complete blood picture including erythrocyte sedimentation rate were retrieved from hospital electronic medical records system. Data was collected on a specially designed Proforma, entered into SPSS version 23.0 and analyzed. Data is presented as mean±SD and frequency and percentages for numerical and categorical variables respectively using tables and figures. Results: In this study the mean age of patients was 34.36 ± 6.41 years with male to female ratio 2.52: 1. Frequency of anemia was 82.6% (n=413), leukocytosis was 46.2% (n=231) and leucopenia in 102 patients (20.4%). Thrombocytosis was detected in 131(26.2%) patients. Raised ESR was observed in 495(99%) of the patients. No association of age and gender was observed with hematological manifestations. However, thrombocytosis was significantly more common in male patients (p-value = 0. 008). Conclusion: Hematological parameters like high Erythrocyte Sedimentation Rate (ESR) and anemia were commonly detected in newly diagnosed patients with pulmonary tuberculosis. Thrombocytosis was seen more commonly in male patients of pulmonary tuberculosis. doi: https://doi.org/10.12669/pjms.38.7.5911 How to cite this:Batool Y, Pervaiz G, Arooj A, Fatima S. Hematological manifestations in patients newly diagnosed with pulmonary tuberculosis. Pak J Med Sci. 2022;38(7):---------. doi: https://doi.org/10.12669/pjms.38.7.5911 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Development of Scoring and Stratification of Severe Lung Involvement in Multidrug-Resistant Pulmonary Tuberculosis Patients

Smitha,

Prabhakar,

Murthy

2022

Curr. Res. Tuberculosis

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Background and Objective:The probability of the presence of risk factors and clinical outcomes in multidrug-resistant pulmonary tuberculosis subjects is undermined. A clinical prediction model was established based on radiological examination. To assess the effectiveness of the prediction model and strengthen both the diagnostic and prognostic applications, we developed and validated a scoring system employing radiological examination. Materials and Methods: The radiological grading categorized severe lung involvement. The study recorded the patient's hemogram and medical history. Radiological grading and clinical investigations were chosen as dependent variables and independent variables, respectively. Data were analyzed using bivariate logistic regression with p<0.2 and multivariate logistic regression analysis with p<0.05. Independent predictor variables and their regression coefficient (β) evaluated. The constant in this study was based on the Framingham study. Results: Hematological changes were observed in the grading of lung severity using ANOVA. The regression analysis identified a history of multidrug-resistant tuberculosis (p = 0.0001) and resistance to more than one anti-tubercular drug (p = 0.026) and a few parameters of hemogram as predictors for an intense lung infection. This study segregated the study subjects into risk categories and evaluated the performance of the scoring system. Conclusion:The score developed helps in stratifying the patients at severe risk of lung involvement alerting the healthcare professional for patients' better pharmaceutical care.

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Hematological Study on Pulmonary Tuberculosis (PTB) Predominance in Quetta.

Cited by 3 publications

References 9 publications

An Investigation into Implications of Tuberculosis Control Efforts in Pakistan: A Comparative Approach

An Investigation into Implications of Tuberculosis Control Efforts in Pakistan: A Comparative Approach

Hematological manifestations in patients newly diagnosed with pulmonary tuberculosis

Development of Scoring and Stratification of Severe Lung Involvement in Multidrug-Resistant Pulmonary Tuberculosis Patients

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