Hematopoiesis toxicity induced by CdTe quantum dots determined in an invertebrate model organism

Li, Teng; Xing, Rui; Zhou, Yanfeng; Zhang, Jue; Su, Yuanyuan; Zhang, Ke‐Qin; He, Yao; Sima, Yang-Hu; Xu, Shiqiang

doi:10.1016/j.biomaterials.2013.12.007

Cited by 59 publications

(59 citation statements)

References 34 publications

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“…Thus, the development of novel QDs with extremely low cytotoxicity (especially Cd-free alternatives) is necessary for further advancement of QD technology15161718. There have been some reports about the cadmium-free QDs such as carbon or CuInS 2 /ZnS QDs192021.…”

mentioning

confidence: 99%

Labeling and in vivo visualization of transplanted adipose tissue-derived stem cells with safe cadmium-free aqueous ZnS coating of ZnS-AgInS2 nanoparticles

Ogihara

Yukawa

Kameyama

et al. 2017

Sci Rep

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The facile synthesis of ZnS-AgInS2 (ZAIS) as cadmium-free QDs and their application, mainly in solar cells, has been reported by our groups. In the present study, we investigated the safety and the usefulness for labeling and in vivo imaging of a newly synthesized aqueous ZnS-coated ZAIS (ZnS-ZAIS) carboxylated nanoparticles (ZZC) to stem cells. ZZC shows the strong fluorescence in aqueous solutions such as PBS and cell culture medium, and a complex of ZZC and octa-arginine (R8) peptides (R8-ZZC) can achieve the highly efficient labeling of adipose tissue-derived stem cells (ASCs). The cytotoxicity of R8-ZZC to ASCs was found to be extremely low in comparison to that of CdSe-based QDs, and R8-ZZC was confirmed to have no influence on the proliferation rate or the differentiation ability of ASCs. Moreover, R8-ZZC was not found to induce the production of major inflammatory cytokines (TNF-α, IFN-γ, IL-12p70, IL-6 and MCP-1) in ASCs. Transplanted R8-ZZC-labeled ASCs could be quantitatively detected in the lungs and liver mainly using an in vivo imaging system. In addition, high-speed multiphoton confocal laser microscopy revealed the presence of aggregates of transplanted ASCs at many sites in the lungs, whereas individual ASCs were found to have accumulated in the liver.

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mentioning

confidence: 99%

Labeling and in vivo visualization of transplanted adipose tissue-derived stem cells with safe cadmium-free aqueous ZnS coating of ZnS-AgInS2 nanoparticles

Ogihara

Yukawa

Kameyama

et al. 2017

Sci Rep

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“…It is found that more than 80% of the cells survive even incubated with 200 µg ml −1 for 36 h, indicating low cytotoxicity of the NCDs. 38 Figs. 7(b)-7(d) are fluorescent images by laser confocal microscope (405 nm excitation) of human osteogenesis sarcoma MG-63 cells incubated with G-NCDs, M-NCDs, and C-NCDs, respectively.…”

mentioning

confidence: 99%

Fluorescently tuned nitrogen-doped carbon dots from carbon source with different content of carboxyl groups

et al. 2015

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In this study, fluorescent nitrogen-doped carbon dots (NCDs) were tuned via varying the sources with different number of carboxyl groups. Owing to the interaction between amino and carboxyl, more amino groups conjugate the surface of the NCDs by the source with more carboxyl groups. Fluorescent NCDs were tuned via varying the sources with different content of carboxyl groups. Correspondingly, the nitrogen content, fluorescence quantum yields and lifetime of NCDs increases with the content of carboxyl groups from the source. Furthermore, cytotoxicity assay and cell imaging test indicate that the resultant NCDs possess low cytotoxicity and excellent biocompatibility.

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“…Quantum dots Apoptosis in mouse blastocysts, inhibited cell proliferation, early-stage blastocyst death in mouse [60] Apoptosis in mouse myoblast cells line [62] Impaired hematopoiesis in an invertebrate model organism [63] Fluorescent silica nanoparticles Abnormal morphology and altered gene expression of human neural stem cells [67] Cell death at high particle doses in neural stem cells [68] Enhanced proliferation of human adipose tissuederived stem cells through ERK1/2 activation [69] Metabolic stress in hMSCs through EGR1, CCND, and E2F1 genes [70] MSC: mesenchymal stem cells; hMSC: human mesenchymal stem cells…”

Section: Superparamagnetic Iron Oxide Nanoparticlesmentioning

confidence: 99%

“…Further in vivo studies have shown that copper oxide QDs bind to genomic DNA, significantly decrease the viability of cells in culture in a concentration--dependent manner, and inhibit mitochondrial caspases 3 and 7. CdTe QDs, especially those that are smaller in size, resulted in impaired haematopoiesis in an invertebrate model organism, Bombyx mori [63]. QD exposure promoted the mitotic nucleus in prohaemocytes and haematocytes similar to peripheral blood stem cells in humans, but aggravated apoptosis.…”

Section: Quantum Dotsmentioning

confidence: 99%

Safety issue of nanoparticles which used for stem cell labeling and tracking

Chang¹,

Lee²

2016

Nanomaterials and Regenerative Medicine

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Hematopoiesis toxicity induced by CdTe quantum dots determined in an invertebrate model organism

Cited by 59 publications

References 34 publications

Labeling and in vivo visualization of transplanted adipose tissue-derived stem cells with safe cadmium-free aqueous ZnS coating of ZnS-AgInS2 nanoparticles

Labeling and in vivo visualization of transplanted adipose tissue-derived stem cells with safe cadmium-free aqueous ZnS coating of ZnS-AgInS2 nanoparticles

Fluorescently tuned nitrogen-doped carbon dots from carbon source with different content of carboxyl groups

Safety issue of nanoparticles which used for stem cell labeling and tracking

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