Hematopoietic and Lung Platelet Biogenesis as a Prognostic Indicator in Idiopathic Pulmonary Fibrosis

Saito, Shigeki; Chung, Cheng Han; Jacob, Alex; Nuradin, Nebil; Meyer, A.; Saito, Toshie; Yang, Haoran; Kolls, Jay K.; Thannickal, Victor J.; Liu, Yaozhong; Lasky, Joseph A.

doi:10.1164/rccm.202206-1195le

Cited by 3 publications

(3 citation statements)

References 10 publications

(10 reference statements)

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“…110 The results suggest that hematopoiesis and lung platelet biogenesis serve as potential prognostic indicators in IPF. 111 The animal models of lung fibrosis show that limiting inflammation is beneficial for disease progression. Unfortunately, the profit on animal encounter obstacles in clinical treatment.…”

Section: Plateletsmentioning

confidence: 99%

“…In mouse pneumonectomy (PNX) models, activated platelets stimulate SDF1 (known as CXCL12) receptors CXCR4 and CXCR7 on PCECs to guide the angiocrine membrane‐type metalloproteinase MMP14, potentiating alveolar epithelial cell expansion and neo‐alveolarization 110 . The results suggest that hematopoiesis and lung platelet biogenesis serve as potential prognostic indicators in IPF 111 . The animal models of lung fibrosis show that limiting inflammation is beneficial for disease progression.…”

Section: Role Of Specific Cell Types In Lung Regenerationmentioning

confidence: 99%

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Lung regeneration: diverse cell types and the therapeutic potential

Chen,

Li,

et al. 2024

MedComm

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Lung tissue has a certain regenerative ability and triggers repair procedures after injury. Under controllable conditions, lung tissue can restore normal structure and function. Disruptions in this process can lead to respiratory system failure and even death, causing substantial medical burden. The main types of respiratory diseases are chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and acute respiratory distress syndrome (ARDS). Multiple cells, such as lung epithelial cells, endothelial cells, fibroblasts, and immune cells, are involved in regulating the repair process after lung injury. Although the mechanism that regulates the process of lung repair has not been fully elucidated, clinical trials targeting different cells and signaling pathways have achieved some therapeutic effects in different respiratory diseases. In this review, we provide an overview of the cell type involved in the process of lung regeneration and repair, research models, and summarize molecular mechanisms involved in the regulation of lung regeneration and fibrosis. Moreover, we discuss the current clinical trials of stem cell therapy and pharmacological strategies for COPD, IPF, and ARDS treatment. This review provides a reference for further research on the molecular and cellular mechanisms of lung regeneration, drug development, and clinical trials.

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Section: Plateletsmentioning

confidence: 99%

Section: Role Of Specific Cell Types In Lung Regenerationmentioning

confidence: 99%

Lung regeneration: diverse cell types and the therapeutic potential

Chen,

Li,

et al. 2024

MedComm

View full text Add to dashboard Cite

show abstract

“…Recently, 5-HT in platelets has been found to be a mediator linking vascular injury and extravascular tissue fibrosis, indicating that 5-HT signaling pathway is a new clinical therapeutic target for pulmonary fibrosis [ 57 ], which also provides ideas for the treatment of later pulmonary fibrosis in patients with burn complicated by inhalation lung injury. At the same time, mean platelet volume and alterations in a blood megakaryocyte gene signature may have prognostic value in idiopathic pulmonary fibrosis (IPF) [ 58 ].…”

Section: Megakaryocytes and Platelets Are Associated With Lung Injurymentioning

confidence: 99%