2004
DOI: 10.1182/blood-2003-07-2534
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Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation

Abstract: In the current study, we tested whether higher numbers of hematopoietic stem cells correlate with the speed of immune reconstitution in a congenic transplantation model (C57BL/Ka, CD45.1, Thy1.13C57BL/6, CD45.2, Thy1.2) using purified hematopoietic stem cells

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Cited by 66 publications
(65 citation statements)
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“…The ability of CD62L Ϫ T cells to facilitate hematopoietic cell engraftment is further supported by faster hematologic recovery ( Figure 3B) and the conversion from mixed to full chimerism ( Figure 3C) after addition of CD62L Ϫ T cells to the graft. These data are in line with recent data published by Dutt et al 26 Because higher numbers of hematopoietic stem 24 and progenitor 32,33 cells correlate with faster T-cell reconstitution after transplantation, facilitation of engraftment may lead to accelerated T-cell reconstitution. Indeed, we did observe in the previous study that CD62L Ϫ T cells enhance T-cell generation from TCD bone marrow cells.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…The ability of CD62L Ϫ T cells to facilitate hematopoietic cell engraftment is further supported by faster hematologic recovery ( Figure 3B) and the conversion from mixed to full chimerism ( Figure 3C) after addition of CD62L Ϫ T cells to the graft. These data are in line with recent data published by Dutt et al 26 Because higher numbers of hematopoietic stem 24 and progenitor 32,33 cells correlate with faster T-cell reconstitution after transplantation, facilitation of engraftment may lead to accelerated T-cell reconstitution. Indeed, we did observe in the previous study that CD62L Ϫ T cells enhance T-cell generation from TCD bone marrow cells.…”
Section: Discussionsupporting
confidence: 91%
“…Because hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation, 24 facilitation of engraftment ( Figure 3) by CD62L Ϫ T cells may lead to enhanced immune reconstitution. Indeed, our published data 11 strongly suggest that allogeneic CD62L Ϫ T cells are able to promote stemor progenitor-derived T-cell generation because TCD BM was used in that study.…”
Section: Cd62l ؊ T Cells Promote Purified Hematopoietic Stem Cell-dermentioning
confidence: 99%
“…After counting, cells were then resuspended in PBS at 4 × 10 7 cells/ml. Recipient lpr mice were lethally irradiated with 10.5 Gy using a cesium irradiator (67). Within 4 hours after irradiation, the mice were injected intravenously via tail vein with 10 7 cells (66)(67)(68).…”
Section: Methodsmentioning
confidence: 99%
“…Recipient lpr mice were lethally irradiated with 10.5 Gy using a cesium irradiator (67). Within 4 hours after irradiation, the mice were injected intravenously via tail vein with 10 7 cells (66)(67)(68). To avoid immunologic responses due to the H-Y antigen, male recipients received male bone marrow cells and females received female bone marrow cells.…”
Section: Methodsmentioning
confidence: 99%
“…Increasing donor HSC dose improves transplantation across genetic barriers by exploiting the tolerance-inducing activity of Lin Ϫ Sca-1 ϩ cells (9) and by accelerating immune reconstitution (29). We therefore used a model that incorporated transfer of donor populations enriched for stem cell characteristics; other investigators have studied graft rejection in models using defined HSC isolated by flow sorting (30).…”
Section: Donor Hsc-enriched Population: Generation Characterizationmentioning
confidence: 99%