Hematopoietic Stem Cell Transplantation Cures Therapy-refractory Aspergillosis in Chronic Granulomatous Disease

Dedieu, Cinzia; Landwehr-Kenzel, Sybille; Thee, Stephanie; Oevermann, Lena; Voigt, Sebastian; Marggraf, Katharina; Schulte, Johannes H.; Lau, Susanne; Roesler, Joachim; Kuehl, Jörn-Sven; Bernuth, Horst von

doi:10.1097/inf.0000000000003109

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…Granulocyte infusions can also be given as a bridge to HSCT [ 381 , 382 ], although there is a risk of allo-immunization with subsequent graft failure [ 383 ], or given post-HSCT as a bridge to myeloid reconstitution [ 384 ]. HSCT with concomitant antifungal therapy, without granulocyte infusions, has also been successful [ 385 ].…”

Section: Aspergillosismentioning

confidence: 99%

Of Mycelium and Men: Inherent Human Susceptibility to Fungal Diseases

Vinh

2023

Pathogens

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In medical mycology, the main context of disease is iatrogenic-based disease. However, historically, and occasionally, even today, fungal diseases affect humans with no obvious risk factors, sometimes in a spectacular fashion. The field of “inborn errors of immunity” (IEI) has deduced at least some of these previously enigmatic cases; accordingly, the discovery of single-gene disorders with penetrant clinical effects and their immunologic dissection have provided a framework with which to understand some of the key pathways mediating human susceptibility to mycoses. By extension, they have also enabled the identification of naturally occurring auto-antibodies to cytokines that phenocopy such susceptibility. This review provides a comprehensive update of IEI and autoantibodies that inherently predispose humans to various fungal diseases.

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