Hematopoietic stem cell transplantation in Saudi Arabia between 1984 and 2016

Shaheen, Marwan; Almohareb, Fahad; AlJohani, Naif I.; Ayas, Mouhab; Chaudhri, Naeem; Abosoudah, Ibraheem; Alotaibi, Sultan; Alshahrani, Mohammed; Alsharif, Fahad; Akhtar, Saad; Al-Humaidan, Hind; Rasheed, Walid; Alfraih, Feras; Al-Anazi, Khalid Ahmed; Alhashmi, Hani; Aldaama, Saad; Hanbali, Amr; Alsaleh, Khalid; Alzahrani, Hazzaa; Ibrahim, Khalid; Al-Awwami, Moheeb; Albeirouti, Bassim; Albeihany, Amal; Alabdulwahab, Amal; Motabi, Ibraheem; Zaidi, Syed Ziauddin A.; Ahmed, Syed Osman; Al‐Jefri, Abdullah; Hussain, Fazal; Al-Ahmari, Ali; Hashmi, Shahrukh K.; El-Solh, Hassan; Al-Seraihy, Amal; Aljurf, Mahmoud

doi:10.1016/j.hemonc.2020.07.008

Cited by 13 publications

(13 citation statements)

References 4 publications

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“…A study conducted by Alsaeed and his group in 2018 reported about 7% prevalence of SCD among the Jazan population where VOC and ACS were the major causes for hospital admission, accounting for 56% and 12%, respectively [17]. Saudi Arabia has one of the world's largest series for HSCT [18]. A total of 6184 HSCTs were conducted in Saudi Arabia between 1984 and 2016 which were mainly performed to treat malignancies such as acute lymphoblastic leukemia, acute myelogenous leukemia, and chronic myelocytic leukemia.…”

Section: Discussionmentioning

confidence: 99%

Awareness and Acceptance of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease in Jazan Province, Saudi Arabia

Hurissi¹,

Hakami²,

Homadi³

et al. 2022

Cureus

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Background: Sickle cell diseases (SCD) are a group of inherited disorders that lead to abnormal beta subunits of hemoglobin (Hb) and are characterized by several complications which can be life-threatening. The prevalence of this disease is high in Jazan province, Saudi Arabia. The current protocol for the treatment of SCD is mainly based on alleviating signs and symptoms to avoid severe complications. Hematopoietic stem cell transplant (HSCT) is considered a definitive therapy for SCD. However, there is a long patient waiting list for HSCT in Saudi Arabia. A lack of community awareness and incorrect information about the importance of HSCT in SCD treatment is believed to be contributing to the shortage in HSCT. Thus, this study aims to assess community awareness and attitudes toward HSCT as a cure for SCD in Jazan province, Saudi Arabia.Methods: An observational cross-sectional retrospective study was conducted in Jazan province. General and demographic data were collected and pretested survey including questions about public knowledge and attitude toward HSCT for SCD were answered. Both t-test and chi-square tests were used for analysis.Results: 1167 participants were included in this study with a mean age of 26 (SD: 8). About 50% of the study participants believed that SCD can be treated and 78% of the study participants already have heard about HSCT. About 57% of the participants defined HSCT correctly and 42% were willing to donate. Better knowledge and positive attitude toward HSCT were significantly reported among patients with SCD or their relatives as well as among people with higher education and healthcare workers (HCW).Conclusion: About 57% of the study participants were able to define HSCT and most related questions were answered correctly. A positive correlation was found between the knowledge about HSCT and people with higher education or those who were diagnosed with SCD or their relatives and friends. Further, only 42% of our study participants were willing to donate, a percent that is positively associated with better knowledge about HSCT. National education programs are needed to enhance the overall awareness of Jazan communities toward HSCT which could contribute to reducing the number of patients waiting for HSCT.

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Section: Discussionmentioning

confidence: 99%

Awareness and Acceptance of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease in Jazan Province, Saudi Arabia

Hurissi¹,

Hakami²,

Homadi³

et al. 2022

Cureus

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“…In pediatric patients, the majority (2326) were allo-HSCTs, while the auto-HSCT represented a small proportion (272). In pediatric patients, a high proportion of HSCT is performed for nonneoplastic hematologic indications, including hemoglobinopathies, primary immunodeficiency disorders, thalassemia, and bone marrow failure syndromes [19]. Five centers are providing stem cell transplant services in Riyadh, two in Jeddah, and one in Dammam.…”

Section: Stem Cell Transplant and High Dose Chemotherapymentioning

confidence: 99%

General Oncology Care in the Kingdom of Saudi Arabia

Abusanad

Alghamdi

Bakkar

et al. 2022

Cancer in the Arab World

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The Kingdom of Saudi Arabia is the largest country in the gulf region. With the recognized increasing cancer burden globally and locally, plus a young population with increasing life expectancy, challenges to provide optimal healthcare are substantial. Several landmark achievements made KSA a pioneer in regional cancer care over the past half a century. Advances in different aspects of cancer care have been commenced to match the aspired vision of 2030. This chapter describes past, present milestones and models of oncology care in the Kingdom and highlights future challenges and plans to improve cancer care further.

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“…HSCT is used to treat several hematologic conditions, including leukemia, lymphoma, multiple myeloma, sickle cell anemia, thalassemia, and inherited immunodeficiency. Stem cell therapy started in Saudi Arabia in the 1980s in a non-official capacity using hematopoietic stem cell transplantation to treat blood diseases like leukemia and inherited immunodeficiency ( 12 ). Research in this area has increased in recent years, resulting in numerous clinical stem cell studies in Saudi Arabia that are registered with the National Institutes of Health ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Public awareness and understanding of stem cell treatments available in Saudi Arabia and their trust in hospitals and research centers involved in stem cell research—a cross sectional study

Aboalola,

Ramadan,

Baadhaim

et al. 2024

Front. Public Health

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IntroductionAlthough stem cell research and therapeutic applications hold great promise for medical advancements, and have rapidly progressed globally, there remains a lack of genuine public awareness of the status of this subject in Saudi Arabia. Successful integration of stem cell therapy into healthcare relies on public awareness, understanding, and trust. Therefore, we aimed in this cross-sectional study to assess the public’s knowledge, awareness, trust, support, participation, and confidence in stem cell treatments and centers involved in it.Materials and methodsA voluntary questionnaire of 20 questions was distributed randomly via social media outlets.ResultsThree thousand five hundred eighty four individuals participated in the survey, with approximately half of them falling within the age range of 35–50 years (46.71%). Majority of the participants, 90.71%, would like to know more about stem cell therapy and more than half of the participants (56.94%) were unfamiliar with the idea, and a comparable proportion (50.41%) expressed concerns about the safety of stem cell therapy. A lower level of awareness, indicated by a score of 5, was evenly distributed across all age groups and genders. However, regardless of gender, older participants—especially those 50 years of age or older—tended to report higher levels of confidence, trust, and support than participants in other age groups. Moreover, trust, support, participation, and confidence score for those attained high school or less was statistically significantly lower than those attained master’s or PhD degree. Of the participants, 33.57% had either received stem cell therapy themselves or known someone who had; about 24.07% of them reported that it was a cosmetic type of treatment.ConclusionThe study emphasizes the persistent need for awareness and educational initiatives to minimize the lack of public awareness and understanding of approved stem cell treatments in Saudi Arabia. It advocates for increased education, transparency, and communication to bridge knowledge gaps and enhance public trust to ensure the understanding of successful treatment.

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Hematopoietic stem cell transplantation in Saudi Arabia between 1984 and 2016

Cited by 13 publications

References 4 publications

Awareness and Acceptance of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease in Jazan Province, Saudi Arabia

Awareness and Acceptance of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease in Jazan Province, Saudi Arabia

General Oncology Care in the Kingdom of Saudi Arabia

Public awareness and understanding of stem cell treatments available in Saudi Arabia and their trust in hospitals and research centers involved in stem cell research—a cross sectional study

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