Hemi-parkinsonism in multiple system atrophy: a PET and MRI study

Kume, Akito; Shiratori, Masayuki; Takahashi, Akira; Kato, Takashi; Ito, Kengo; Tadokoro, Masanori; Sakuma, Shinya

doi:10.1016/0022-510x(92)90007-8

Cited by 19 publications

(4 citation statements)

References 25 publications

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“…21,22 As mentioned earlier, the clinical manifestation of parkinsonism develops asymmetrically in approximately 40%-50% of patients with MSA-p. 8,9 We believe that 3T SWI can visualize asymmetric putaminal changes, including atrophy and iron deposition, in the contralateral, symptomatic side. This finding was not clearly indicated by previous imaging studies, even those that used 3T imaging or 3T SWI.…”

Section: Discussionmentioning

confidence: 90%

Differentiation of Parkinsonism-Predominant Multiple System Atrophy from Idiopathic Parkinson Disease Using 3T Susceptibility-Weighted MR Imaging, Focusing on Putaminal Change and Lesion Asymmetry

Hwang¹,

Sohn

Kang³

et al. 2015

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 90%

Differentiation of Parkinsonism-Predominant Multiple System Atrophy from Idiopathic Parkinson Disease Using 3T Susceptibility-Weighted MR Imaging, Focusing on Putaminal Change and Lesion Asymmetry

Hwang¹,

Sohn

Kang³

et al. 2015

AJNR Am J Neuroradiol

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“…Gelman et al noticed a strong linear correlation of transverse relaxation rates with estimates of local nonheme iron concentrations in several gray matter regions of normal adults at 3.0 T by using a gradient-echo sampling of free induction decay and echo (GESFIDE) sequence [26,27]. Several authors [28][29][30][31] reported a correlation between neuropathologic findings of MSA-P and the presence of abnormal hypointensity on T2-weighted images within the dorsolateral putamen and an adjacent abnormal hyperintense band on T2-weighted images or proton density-weighted images.…”

Section: Discussionmentioning

confidence: 98%

Sensitivity of T2-weighted FSE sequences towards physiological iron depositions in normal brains at 1.5 and 3.0�T

et al. 2004

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To evaluate the sensitivity of T2-weighted fast spin-echo (FSE) sequences to physiological iron depositions in normal brains at MR imaging field strengths of 1.5 and 3.0 T. T2-weighted FSE sequences acquired at 1.5 and 3.0 T clinical imaging systems (Gyroscan Intera, Philips Medical Systems, Best, The Netherlands) were compared by means of MRI in phantoms ( n=6) and healthy volunteers ( n=10). Contrast-to-noise ratios (CNRs) of tubes doped with iron oxides at different concentrations and of brain areas with physiological iron depositions (nucleus ruber, substantia nigra, globus pallidus) were calculated for either field strength. Apparent susceptibility effects of iron-containing brain structures were qualitatively analyzed by comparing the degree of visible hypointensity by a score system at either field strength. The mean CNR of iron oxide tubes and iron-containing brain areas was significantly decreased at 3.0 T. Qualitative analysis confirmed these measurements. Detection and diagnosis of brain disorders with altered iron content such as neurodegenerative parkinsonian disorders (NPD) or intracerebral hemorrhage should benefit from the increased sensitivity of T2-weighted FSE sequences to susceptibility effects at 3.0 T.

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“…Other abnormal putaminal findings reported in atypical parkinsonism and multiple system atrophy are the presence of putaminal atrophy on T2 weighted and proton density images4 6 8 10 11 and a hyperintense rim at the lateral putaminal edge, often accompanied by putaminal hypointensity 312 Testa et al 13 also described putaminal hyp er intensity on T2 weighted 0.5 T scans which corresponded to putaminal hyp o intensity on 1.5 T images in patients with multiple system atrophy 13…”

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confidence: 97%

Clinical usefulness of magnetic resonance imaging in multiple system atrophy

Schrag

Kingsley

Phatouros

et al. 1998

Journal of Neurology, Neurosurgery & Psychiatry

255

180

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Objectives-To determine the sensitivity, specificity, and positive predictive values of a selection of abnormal findings in the putamen and infratentorial structures on routine magnetic resonance imaging for distinguishing between multiple system atrophy, idiopathic Parkinson's disease, and age matched controls. Patients and methods-Two neuroradiologists blindly and independently rated axial T2 weighted and proton density MRI of 44 patients with multiple system atrophy, 47 patients with idiopathic Parkinson's disease, and 45 controls. High field (1.5 T) scans were available in 16 patients with multiple system atrophy, 15 patients with idiopathic Parkinson's disease, and 16 controls. All other patients had 0.5 T scans. Results-On both 0.5 and 1.5 T scans the following items had high specificity but low sensitivity: putaminal atrophy, a hyperintense putaminal rim, and infratentorial signal change. Finding any infratentorial abnormality gave higher sensitivity but lower specificity. Putaminal isointensity or hypointensity relative to globus pallidus, absolute putaminal hypointensity, and altered size of the olives were not useful discriminators. The overall sensitivity was 73% on 0.5 T and 88% on 1.5 T scans. The specificities of these findings for multiple system atrophy in comparison to idiopathic Parkinson's disease and controls on 0.5 T were 95% and 100% respectively, and on 1.5 T were 93% and 91% respectively. Finding any of the described abnormalities on MRI gave a positive predictive value of 93% on the 0.5 T machine, and 85% on the 1.5 T scanner. (J Neurol Neurosurg Psychiatry 1998;65:65-71)

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Hemi-parkinsonism in multiple system atrophy: a PET and MRI study

Cited by 19 publications

References 25 publications

Differentiation of Parkinsonism-Predominant Multiple System Atrophy from Idiopathic Parkinson Disease Using 3T Susceptibility-Weighted MR Imaging, Focusing on Putaminal Change and Lesion Asymmetry

Differentiation of Parkinsonism-Predominant Multiple System Atrophy from Idiopathic Parkinson Disease Using 3T Susceptibility-Weighted MR Imaging, Focusing on Putaminal Change and Lesion Asymmetry

Sensitivity of T2-weighted FSE sequences towards physiological iron depositions in normal brains at 1.5 and 3.0�T

Clinical usefulness of magnetic resonance imaging in multiple system atrophy

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