Hemochromatosis

Clinical, biochemical and histological features of primary haemochromatosis: a report of 67 cases

“…The more frequent involvement of the gastric body compared with the antrum is probably due to less rapid cell turnover at this site. Our data indicate that the diagnostic value of bone marrow aspirate and gastric biopsy in primary haemochromatosis is limited, in agreement with some previous reports (26,27) but not with others (28,29). In 45% of the cases studied iron deposits were found in the skin, but skin colour did not correlate with iron or melanin deposits.…”

Studies on Copper Metabolism. Vii. Blood Copper in Pregnancy and Various Pathologic States 1

“…Blood specimens from patients with hemochromatosis were kindly furnished us by Dr. F. Gardner, Boston, and by Dr. Ian Wood, Melbourne, Australia. Eleven were sent by the latter and make up a part of the material studied by Althausen and his associates (35). From the data in Table I Blood copper and iron determinations were made on several patients during therapy.…”

Increased Thyroid Function in Haemochromatosis

“…Finally, there was no evidence of hypogonadism, which is one of the more constant features of haemochromatosis. It has been suggested that hypogonadism with testicular atrophy in this condition is due to damage to the anterior lobe of the pituitary by deposits of haemosiderin, which may be particularly marked in the basophil cells (Sheldon, 1935;Althausen et al, 1951).…”