2007
DOI: 10.1002/jbm.a.31211
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Hemocompatibility evaluation of poly(diol citrate) in vitro for vascular tissue engineering

Abstract: One of the ongoing challenges in tissue engineering is the synthesis of a hemocompatible vascular graft. Specifically, the material used in the construct should have antithrombogenic properties and support the growth of vascular cells. Our laboratory has designed a novel biodegradable, elastomeric copolymer, poly(1,8-octanediol citrate) (POC), with mechanical and degradation properties suitable for vascular tissue engineering. The hemocompatibility of POC in vitro and its ability to support the attachment and … Show more

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Cited by 128 publications
(103 citation statements)
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“…MALDI spectra further confirmed the low-molecular-mass of POC and POCA pre-polymers (Mw 915 and 917 Da, Mn 836 and 828, PD 1.09 and 1.11, respectively), in good agreement with previous results [28, 29, 41]. Characteristic spacing between clusters of peaks exist of 128 Da, 174 Da and 302 Da, corresponding to the addition of an octanediol (D), citric acid (C) or C 1 D 1 segment to oligomers, respectively, with evidence of pre-polymer oligomers of up to C 5 D 5 length present in the prepolymer mixture (Figure 3).…”
Section: Resultssupporting
confidence: 90%
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“…MALDI spectra further confirmed the low-molecular-mass of POC and POCA pre-polymers (Mw 915 and 917 Da, Mn 836 and 828, PD 1.09 and 1.11, respectively), in good agreement with previous results [28, 29, 41]. Characteristic spacing between clusters of peaks exist of 128 Da, 174 Da and 302 Da, corresponding to the addition of an octanediol (D), citric acid (C) or C 1 D 1 segment to oligomers, respectively, with evidence of pre-polymer oligomers of up to C 5 D 5 length present in the prepolymer mixture (Figure 3).…”
Section: Resultssupporting
confidence: 90%
“…Our laboratory has previously described the synthesis and characterization of polydiolcitrates (PDC), biodegradable non-toxic polyesters that have been shown to be useful for several tissue engineering applications [2831]. Herein we demonstrate that these polymers can be easily engineered to have enhanced, biologically relevant antioxidant activity by incorporating ascorbic acid (AA) into the polymer network (Figure 1).…”
Section: Introductionmentioning
confidence: 79%
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“…[20][21][22] Although many resorbable biopolymers are available, there are only a few that are elastomeric, including biodegradable polyurethane (PEU), poly(trimethylene carbonate) (TMC), poly (glycerol sebacate) (PGS), poly-4-hyroxybutyrate (P4HB), and poly (1,8 octanediol citrate)-(POC). 14,17,[22][23][24][25][26][27][28] Among these, poly (diol citrate) POC is one of the easiest to synthesis and cost of monomer materials is low. A schematic of the structure of POC is shown in Figure 1.…”
mentioning
confidence: 99%
“…Resorbable biopolymers with modifiable mechanical properties have been developed for closure of bone defects [11][12][13][14] and creation of artificial cartilage, 15,16 vascular systems, [17][18][19] and nerve constructs. [20][21][22] Although many resorbable biopolymers are available, there are only a few that are elastomeric, including biodegradable polyurethane (PEU), poly(trimethylene carbonate) (TMC), poly (glycerol sebacate) (PGS), poly-4-hyroxybutyrate (P4HB), and poly (1,8 octanediol citrate)-(POC).…”
mentioning
confidence: 99%