2017
DOI: 10.1016/j.actbio.2016.11.005
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Hemocompatibility studies on a degradable polar hydrophobic ionic polyurethane (D-PHI)

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Cited by 30 publications
(17 citation statements)
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“…This study revealed that the expression of activated platelets was greater compared to the control group (Figure 3). This result corroborates with other studies that also identified a tendency to thrombus formation the longer the CVC remains inserted in the patient (Brockman et al, 2017;Gunawansa et al, 2018;Ivert et al, 2019). Platelet activation is a factor that worsens the clinical condition of patients with chronic end-stage kidney disease because, due to a natural state of hypercogulability intrinsic to the disease, the CVC can increase the accumulation of various pro-coagulating factors, platelets and leukocytes, leading to thrombus formation (Yu et al, 2018).…”
Section: Flow Cytometrysupporting
confidence: 91%
See 1 more Smart Citation
“…This study revealed that the expression of activated platelets was greater compared to the control group (Figure 3). This result corroborates with other studies that also identified a tendency to thrombus formation the longer the CVC remains inserted in the patient (Brockman et al, 2017;Gunawansa et al, 2018;Ivert et al, 2019). Platelet activation is a factor that worsens the clinical condition of patients with chronic end-stage kidney disease because, due to a natural state of hypercogulability intrinsic to the disease, the CVC can increase the accumulation of various pro-coagulating factors, platelets and leukocytes, leading to thrombus formation (Yu et al, 2018).…”
Section: Flow Cytometrysupporting
confidence: 91%
“…The hemostatic process of platelet activation includes the recruitment of platelets to the subendothelial matrix whenever there is vascular damage and release of tissue factor which; when activated, the platelets express glycoproteins from surfaces that interact with other platelets, vascular endothelium and inflammatory cells (Brockman, Kizhakkedathu, & Santerre, 2017;Gunawansa, Sudusinghe, & Wijayaratne, 2018;Ivert et al, 2019). This process stimulates thrombus development in the presence of a central venous catheter (CVC), responsible for most CVC dysfunctions in hemodialysis sessions (Gunawansa et al, 2018).…”
Section: Introductionmentioning
confidence: 99%
“…The platelet adhesion on materials surface is an effective and frequently used measurement to evaluate the hemocompatibility of blood-contacting biomaterials [49]. The platelet adhesion on the composite films after contacting with rabbit PRP was assessed by SEM observation, and the representative micrographs are given in Figure 7.…”
Section: Resultsmentioning
confidence: 99%
“…1 The coagulation system can be triggered by the intrinsic or extrinsic pathway. [2][3][4] Contact between factor XII and the CVC surface can stimulate the intrinsic pathway, while the extrinsic pathway can be stimulated by contact between CVCs and the subendothelial layer of the vein. [3][4][5] This latter pathway occurs when the endothelium is injured, allowing plasma factor VIIa to form a complex with the tissue factor (TF) of the exposed subendothelial layer.…”
Section: Introductionmentioning
confidence: 99%
“…[2][3][4] Contact between factor XII and the CVC surface can stimulate the intrinsic pathway, while the extrinsic pathway can be stimulated by contact between CVCs and the subendothelial layer of the vein. [3][4][5] This latter pathway occurs when the endothelium is injured, allowing plasma factor VIIa to form a complex with the tissue factor (TF) of the exposed subendothelial layer. 5 Activation of the coagulation system leads to platelet activation and the expression of glycoprotein complexes such as integrin αIIbβ3 (CD41a) or P-selectin (CD62P), which in turn regulate coagulation reactions that lead to thrombin generation (TG).…”
Section: Introductionmentioning
confidence: 99%