2012
DOI: 10.1159/000336094
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Hemodialysis with a Dialyzer Loaded with Argatroban May Be Performed in vivo without a Systemic Anticoagulant

Abstract: Background/Aims: Anticoagulation in hemodialysis (HD) patients at high risk of bleeding remains an intractable problem. Simulating endothelial cells by releasing anticoagulant on the membrane may be a promising alternative. Methods: We modified a polyacrylonitrile (PAN) dialyzer by loading argatroban into its membrane and verified its anticoagulation efficiency and its influence on coagulation markers such as activated partial thromboplastin time (aPTT), D-dimer and thrombin-antithrombin complex (TAT) in an an… Show more

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Cited by 6 publications
(1 citation statement)
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“…The results demonstrated AG dialyzer is effective to use in heparinfree hemodialysis. 29 In this study, we introduced argatroban into PES by acetylating, oxidating and amidation reaction to prepare AG graed polyethersulfone matrix (PES-AG). Then, PES-AG was blended with PES in different proportions to prepare PES/PES-AG membrane.…”
Section: Introductionmentioning
confidence: 99%
“…The results demonstrated AG dialyzer is effective to use in heparinfree hemodialysis. 29 In this study, we introduced argatroban into PES by acetylating, oxidating and amidation reaction to prepare AG graed polyethersulfone matrix (PES-AG). Then, PES-AG was blended with PES in different proportions to prepare PES/PES-AG membrane.…”
Section: Introductionmentioning
confidence: 99%