Hemodynamic and Emotional Responses to a Psychological Stressor After Cardiac Transplantation

Abstract

This pattern cannot be attributed to the experience of major heart surgery or to cardiac disease. Nor can it be explained by differences in central processing of stress. Correspondingly the changed hemodynamic response to the Stroop test after cardiac transplantation evidently does not affect patients' emotional responses. The hemodynamic findings are consistent with an increased reliance on hormonal rather than neuronal hemodynamic regulation after cardiac transplantation.

Ivabradine reduces baseline and stress-induced increase of heart rate and blood pressure and modulates neuroendocrine stress response in rats depending on stressor intensity

“…Transmission of signals from the heart to the brain is altered in patients who have received a heart transplant. However, published data indicate that the stress response is not affected in these patients (Salmon et al 2001). This discrepancy between our findings and the above-mentioned data might be related to several factors.…”

Solid Organ Transplantation in the Sverdlovsk Region: Experience and Perspectives of Development

“…Таким образом, СОКБ № 1 являет-ся достойным примером взаимодействия с другими Показатели выживаемости пациентов соответс-твуют показателям ведущих российских центров трансплантации донорских органов. Определенный вклад в достижение высоких качественных показа-телей трансплантологических операций СОКБ № 1 вносит система психологического сопровождения пациентов, как находящихся в листе ожидания, так и тех, кто получил донорский орган, а также их родственников [2][3][4].…”

“…В ряде исследований доказано, что трансплан-тация органов как метод лечения эффективнее, чем консервативная терапия, как в отношении качества и продолжительности жизни пациентов, так и эко-номически [3][4][5].…”

Role of psychological factors in the clinical course of heart transplant patients

“…It remains to be determined, however, which of the multiple outcome categories were predicted by depression and social isolation. Specifically, a small network was present in 11 of 42 (26%) patients who died or deteriorated during follow-up, 19 of 83 (23%) in those with urgent transplantation, 9 of 30 (30%) with elective transplantation, 23 of 142 (16%) for those still on the waiting list, and 3 of 17 (18%) of those who were de-listed after clinical improvements.…”

“…Thus, hemodynamic and blood chemistry responses to exercise and acute mental distress may be elevated or sustained because they rely disproportionately on hormonal rather than neuronal regulation in heart transplant recipients. 19 Clinical implications include the potential need for screening and targeted interventions for depression and social isolation in pre-and post-transplant patients. These psychosocial factors are also important for the increasing number of patients receiving a left ventricular assist device.…”