Hemodynamic changes and stress response during BIS-guided TCI anesthesia with propofol-fentanyl in laparoscopic versus open cholecystectomy

Samhan, Yasser M.; Radwan, K; Youssef, Maha; Ebied, Reham Said; Zeidan, Mohamed A.; Bendary, Omnia El; Hassan, Mona M.

doi:10.1016/j.egja.2015.09.014

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…The effects of anaesthesia on hemodynamic changes in patients undergoing laparoscopic vs open cholecystectomy has recently been reported by Samhan et al, (2016). Although they do not comment on routine haematological or biochemistry based parameters, their findings do report on changes seen in norepinephrine, epinephrine and cortisol; which all increase during surgery and may have an effect on haemostasis [ 18 ]. Increases in these hormone levels during surgery may have an effect on routine blood parameters.…”

Section: Discussionmentioning

confidence: 99%

A pilot study evaluating changes to haematological and biochemical tests after Flexible Ureterorenoscopy for the treatment of kidney stones

et al. 2017

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BackgroundCurrently there is limited research documenting the changes in blood parameters, following Flexible Ureterorenoscopy. This study aims to determine whether there are any changes in haematology and biochemistry parameters, following Flexible Ureterorenoscopy for the treatment of kidney stones.Methods40 consecutive patients aged between 27–87 years (median 49 years) undergoing Flexible Ureterorenoscopy for the treatment of kidney stones were recruited (26 male, 14 female). Blood samples were collected from each patient at four time points: baseline (pre-operatively) followed by 30 minutes, 120 minutes and 240 minutes post-operatively. On these samples, routine haematological and biochemistry tests were carried out. In addition to the assessment of clinical parameters prospectively from the medical notes.ResultsThere was a significant decrease observed following Flexible Ureterorenoscopy in the following parameters: lymphocytes (p = 0.007), eosinophils (p = 0.001), basophils (p = 0.001), haemoglobin (p = 0.002), red blood cells (p = 0.001), platelet count (p = 0.001), fibrinogen concentration (p = 0.001), von Willebrand factor (p = 0.046), C reactive protein (p = 0.01), total protein (p = 0.001), albumin (p = 0.001), globulin (p = 0.001) and alkaline phosphatase (p = 0.001). In addition, there was a significant increase observed in the following parameters: white blood cells (p = 0.001), neutrophils (p = 0.001), activated partial thromboplastin time (p = 0.001), total bilirubin (p = 0.012), creatinine (p = 0.008), sodium (p = 0.002) and potassium (p = 0.001). Limiting factors for this study were the sample size, and restriction on the recruitment time points.ConclusionsSignificant changes were noted to occur in haematology and biochemistry parameters following Flexible Ureterorenoscopy. Some of the data presented in this study may represent the ‘normal’ post-operative response following FURS, as no major complications occurred, in the majority of our patients. This data on the ‘normal response’ will need to be validated but may ultimately aid clinicians in distinguishing patients at risk of complications, if reproduced in larger multi-centre studies.

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Section: Discussionmentioning

confidence: 99%

A pilot study evaluating changes to haematological and biochemical tests after Flexible Ureterorenoscopy for the treatment of kidney stones

et al. 2017

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Comparative Study of Fentanyl, Butorphanol and Nalbuphine in Attenuation of Haemodynamic Responses in Laparoscopic Cholecystectomy

Rekhi¹,

Grewal²,

Kumar³

et al. 2018

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BACKGROUND Numerous attempts have been made in the past to attenuate the haemodynamic responses occurring during laparoscopic cholecystectomy. The present study compared the effect of three opioids namely Butorphanol, Fentanyl and Nalbuphine in obtundation of haemodynamic responses in laparoscopic cholecystectomy in terms of Heart rate, BP (SBP, DBP and MAP) and secondary aim was to calculate duration of analgesia and sedation score. MATERIALS AND METHODS This was a randomised study comparing three opioid drugs-nalbuphine, fentanyl and butorphanol. It was carried out on 75 patients of either sex aged 18-60 years scheduled for elective laparoscopic cholecystectomy under GA. Subjects were enrolled into three groups-Group B (n= 25) patients received inj. Butorphanol 25 mcg/kg IV, Group F (n= 25) received inj. Fentanyl 2 mcg/kg IV and Group N (n= 25) patients received inj. Nalbuphine 0.2 mg/kg 5 minutes before the induction. RESULT At the time of extubation, mean MAP in Group B, F and N was 99.88, 95.32 and 97.24 respectively. This difference is highly significant when compared statistically (p value is 0.005). CONCLUSION With this study, we conclude that the administration of intravenous fentanyl and nalbuphine five minutes prior to induction of anaesthesia helps in better obtundation of haemodynamic responses to laparoscopic cholecystectomy than butorphanol.

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Hemodynamic changes and stress response during BIS-guided TCI anesthesia with propofol-fentanyl in laparoscopic versus open cholecystectomy

Abstract: (2016) Hemodynamic changes and stress response during BIS-guided TCI anesthesia with propofol-fentanyl in laparoscopic versus open cholecystectomy,

Cited by 2 publications

References 29 publications

A pilot study evaluating changes to haematological and biochemical tests after Flexible Ureterorenoscopy for the treatment of kidney stones

A pilot study evaluating changes to haematological and biochemical tests after Flexible Ureterorenoscopy for the treatment of kidney stones

Comparative Study of Fentanyl, Butorphanol and Nalbuphine in Attenuation of Haemodynamic Responses in Laparoscopic Cholecystectomy

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