Hemodynamic Compromise Rejection Predicts Future Cardiac Allograft Vasculopathy and Nonfatal Major Adverse Cardiac Events

Abstract

enzyme was measured in a lactonase assay using 5-HETE lactone as the substrate. The results showed no significant difference in lactonase activity between the wild-type and variant enzymes. Based on these preliminary studies, we conclude that PON2 lactonase activity may not be associated with the predicted epidemiological link between PON2 polymorphisms and cardiovascular disease.