1989
DOI: 10.1002/clc.4960120407
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Hemodynamic effects of continuous infusion of AR‐C 239 in left ventricular failure

Abstract: Summary: AR-C 239 is a new specific alpha, antagonist drug with an action similar to that of prazosin. In dogs it appears to be specific for the alpha, adrenoreceptor. AR-C 239 was tested in 11 patients (49 5 11 years old) with left heart failure, who had not received any previous treatment. The drug was infused intravenously with a stepwise increase in dose, producing three stable plasma concentration plateaus: 10 +-2, 51 'r 3, and 138 5 55 ng/ml. Hemodynamic data were collected at time TO before drug infusio… Show more

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