Hemodynamic responses to photic stimulation in neonates

Hoshi, Yoko; Kohri, Shunji; Matsumoto, Yoshinori; Cho, Kazutoshi; Matsuda, Tadashi; Okajima, Satoru; Fujimoto, Seiichiro

doi:10.1016/s0887-8994(00)00195-8

Cited by 53 publications

(40 citation statements)

References 15 publications

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“…Total Hb is also significantly correlated to blood oxygenation level-dependent (BOLD) signals as well as oxy-Hb (Strangman et al, 2002), although BOLD and oxy-Hb exhibit more nonlinearity to sustained stimulation than CBF or total Hb (Sadato and Toyada, 2006). However, suitability of total Hb as a parameter may depend on various factors such as the cortex studied, age, task demand, and individual vascular responsiveness, because these factors influence hemodynamics of deoxy-Hb (Meek et al, 1998;Sakatani et al, 1999;Hoshi et al, 2000;Zaramella et al, 2001). Total Hb as a functional index had given consistent results in previous studies for assessing the lateralization of language function (Watanabe et al, 1998;Furuya and Mori, 2003;Sato et al, 2003) and is regarded to be suitable for our study.…”

Section: Methodsmentioning

confidence: 57%

Neural Attunement Processes in Infants during the Acquisition of a Language-Specific Phonemic Contrast

Minagawa‐Kawai¹,

Mori²,

Naoi³

et al. 2007

J. Neurosci.

142

130

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To elucidate the developmental neural attunement process in the language-specific phonemic repertoire, cerebral hemodynamic responses to a Japanese durational vowel contrast were measured in Japanese infants using near-infrared spectroscopy. Because only relative durational information distinguishes this particular vowel contrast, both first and second language learners have difficulties in acquiring this phonemically crucial durational difference. Previous cross-linguistic studies conducted on adults showed that phonemespecific, left-dominant neural responses were observed only for native Japanese listeners. Using the same stimuli, we show that a larger response to the across-category changes than to the within-category changes occurred transiently in the 6-to 7-month-old group before stabilizing in the groups older than 12 months. However, the left dominance of the phoneme-specific response in the auditory area was observed only in the groups of 13 months and above. Thus, the durational phonemic contrast is most likely processed first by a generic auditory circuit at 6 -7 months as a result of early auditory experience. The neural processing of the contrast is then switched over to a more linguistic circuit after 12 months, this time with a left dominance similar to native adult listeners.

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Section: Methodsmentioning

confidence: 57%

Neural Attunement Processes in Infants during the Acquisition of a Language-Specific Phonemic Contrast

Minagawa‐Kawai¹,

Mori²,

Naoi³

et al. 2007

J. Neurosci.

142

130

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“…Most studies using NIRS to assess cortical function have been carried out on adult subjects. In infants, NIRS has been used to assess the activities of the visual cortex induced by a checkerboard or flashlight simulation [Meek et al, 1998;Hoshi et al, 2000], activation of the frontal cortex by music stimulation [Sakatani et al, 1999], activation of the temporal cortex by acoustic stimulation [Zaramella et al, 2001] and activation of the olfactory cortex by odor stimulation [Bartocci et al, 2000].…”

Section: Introductionmentioning

confidence: 99%

Noninvasive optical imaging in the visual cortex in young infants

Kusaka

Kawada

Okubo

et al. 2004

Human Brain Mapping

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During the developmental stage, the brain undergoes anatomic, functional, and metabolic changes necessary to support the complex adaptive behavior of a mature individual. Estimation of developmental changes occurring in different regions of the brain would provide a means of relating various behavioral phenomena to maturation-specific brain structures, thereby providing useful information on structure-function relationships in both normal and disease states. We used multichannel near-infrared spectroscopy (MNIRS), a new noninvasive imaging technique for revealing the course of neural activity in selected brain regions, to monitor the activities of the visual cortex as mirrored by hemodynamic responses in infants subjected to photostimulation during natural sleep. In the infants, oxyhemoglobin and total hemoglobin decreased and deoxyhemoglobin increased in the visual cortex with photostimulation. This pattern of responses was different from the response pattern in adults reported previously. The different patterns of responses to photostimulation in the visual cortices of infants and adults might reflect developmental and behavioral differences. It may reflect a different functional organization of the visual cortex in infants or ongoing retinal development. Our results demonstrated that regional hemodynamic change could be detected in a small area around the visual cortex. MNIRS offers considerable potential for research and noninvasive clinical applications. Hum. Brain Mapp. 22:122-132, 2004.

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“…4 In adults, variable degrees of NIRS sensitivity have been described, but little is known on repeatability of the signals. 5,6 Further, while relatively few and controversial information on HR in response to visual stimulation in newborn infants has been reported in the literature, [7][8][9][10][11] information on reproducibility or potential optical neuronal signals in newborns is lacking. Previous NIRS studies measuring activation of the visual cortex did not find significant HRs in all newborn infants, 4 even though all of them were healthy.…”

mentioning

confidence: 99%

Multimodal recording of brain activity in term newborns during photic stimulation by near-infrared spectroscopy and electroencephalography

et al. 2012

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In this study 14 healthy term newborns (postnatal mean age 2.1 days) underwent photic stimulation during sleep on two different days. Near-infrared spectroscopy (NIRS) and electroencephalography (EEG) was acquired simultaneously. The aims of the study were: to determine (i) the sensitivity and (ii) the repeatability of NIRS to detect the hemodynamic response, (iii) the sensitivity and (iv) the repeatability of EEG to detect a visual evoked potential (VEP), (v) to analyze optical data for the optical neuronal signal, and (vi) to test whether inadequate stimulation could be reason for absent hemodynamic responses. The results of the study were as follows. (i) Sensitivity of NIRS was 61.5% to detect hemodynamic responses; (ii) their reproducibility was 41.7%. A VEP was detected (iii) in 96.3% of all subjects with (iv) a reproducibility of 92.3%. (v) In two measurements data met the criteria for an optical neuronal signal. The noise level was 9.6·10-5% change in optical density. (vi) Insufficient stimulation was excluded as reason for absent hemodynamic responses. We conclude that NIRS is an promising tool to study cognitive activation and development of the brain. For clinical application, however, the sensitivity and reproducibility on an individual level needs to be improved. Abstract. In this study 14 healthy term newborns (postnatal mean age 2.1 days) underwent photic stimulation during sleep on two different days. Near-infrared spectroscopy (NIRS) and electroencephalography (EEG) was acquired simultaneously. The aims of the study were: to determine (i) the sensitivity and (ii) the repeatability of NIRS to detect the hemodynamic response, (iii) the sensitivity and (iv) the repeatability of EEG to detect a visual evoked potential (VEP), (v) to analyze optical data for the optical neuronal signal, and (vi) to test whether inadequate stimulation could be reason for absent hemodynamic responses. The results of the study were as follows. (i) Sensitivity of NIRS was 61.5% to detect hemodynamic responses; (ii) their reproducibility was 41.7%. A VEP was detected (iii) in 96.3% of all subjects with (iv) a reproducibility of 92.3%. (v) In two measurements data met the criteria for an optical neuronal signal. The noise level was 9.6 · 10 −5 % change in optical density. (vi) Insufficient stimulation was excluded as reason for absent hemodynamic responses. We conclude that NIRS is an promising tool to study cognitive activation and development of the brain. For clinical application, however, the sensitivity and reproducibility on an individual level needs to be improved.

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Hemodynamic responses to photic stimulation in neonates

Cited by 53 publications

References 15 publications

Neural Attunement Processes in Infants during the Acquisition of a Language-Specific Phonemic Contrast

Neural Attunement Processes in Infants during the Acquisition of a Language-Specific Phonemic Contrast

Noninvasive optical imaging in the visual cortex in young infants

Multimodal recording of brain activity in term newborns during photic stimulation by near-infrared spectroscopy and electroencephalography

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