Hemofiltration: treating and preventing infection

Turner, Paul; Humphreys, H.

doi:10.1111/j.1469-0691.1996.tb00210.x

Cited by 6 publications

(2 citation statements)

References 53 publications

(53 reference statements)

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“…It was thus more sensitive than BAL/PSB, although the number of patients with confirmed VAP was small. The major confounding factor affecting CPIS is the extensive use of continuous haemofiltration in intensive care, which misleadingly lowers body temperature [38].…”

Section: Discussionmentioning

confidence: 99%

The diagnosis of ventilator-associated pneumonia using non-bronchoscopic, non-directed lung lavages

Flanagan¹,

Findlay

Magee

et al. 2000

Intensive Care Med

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NBL is a simple, safe, cheap, readily-available method of diagnosing ventilator-associated pneumonia with comparable diagnostic accuracy to bronchoscopic techniques. Quantitation of respiratory tract cultures can exclude pneumonia in patients with equivocal clinical signs. The diagnostic threshold should vary depending on the length of ventilation, likelihood of pneumonia and antibiotic administration. The Bacterial Index is a flawed mathematical device that has no contributory role in pneumonia diagnosis. The CPIS has some diagnostic role in selected cohorts of ventilated patients.

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Section: Discussionmentioning

confidence: 99%

The diagnosis of ventilator-associated pneumonia using non-bronchoscopic, non-directed lung lavages

Flanagan¹,

Findlay

Magee

et al. 2000

Intensive Care Med

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“…Previous studies demonstrated that melatonin could significantly alleviate tau hyperphosphorylation caused by wortmannin and ockadaic acid in N2a and SH‐SY5Y cells . Melatonin treatment could prevent wortmannin‐induced activation of glycogen synthase kinase‐3 (GSK‐3) and resist oxidative stress . These results suggested that melatonin exerted neuroprotective effects against AD.…”

Section: Introductionmentioning

confidence: 93%

Melatonin ameliorates anxiety and depression‐like behaviors and modulates proteomic changes in triple transgenic mice of Alzheimer's disease

et al. 2017

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Alzheimer's disease (AD) is a devastating neurodegenerative disease accompanied by neuropsychiatric symptoms, such as anxiety and depression. The levels of melatonin decrease in brains of AD patients. The potential effect of melatonin on anxiety and depression behaviors in AD and the underlying mechanisms remain unclear. In this study, we treated 10-month-old triple transgenic mice of AD (3xTg-AD) with melatonin (10 mg/kg body weight/day) for 1 month and explored the effects of melatonin on anxiety and depression-like behaviors in 3xTg-AD mice and the protein expression of hippocampal tissues. The behavioral test showed that melatonin ameliorated anxiety and depression-like behaviors of 3xTg-AD mice as measured by open field test, elevated plus maze test, forced swimming test, and tail suspension test. By carrying out two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) coupled with mass spectrometry, we revealed a total of 46 differentially expressed proteins in hippocampus between the wild-type (WT) mice and non-treated 3xTg-AD mice. A total of 21 differentially expressed proteins were revealed in hippocampus between melatonin-treated and non-treated 3xTg-AD mice. Among these differentially expressed proteins, glutathione S-transferase P 1 (GSTP1) (an anxiety-associated protein) and complexin-1 (CPLX1) (a depression-associated protein) were significantly down-regulated in hippocampus of 3xTg-AD mice compared with the WT mice. The expression of these two proteins was modulated by melatonin treatment. Our study suggested that melatonin could be used as a potential candidate drug to improve the neuropsychiatric behaviors in AD via modulating the expression of the proteins (i.e. GSTP1 and CPLX1) involved in anxiety and depression behaviors. © 2017 BioFactors, 43(4):593-611, 2017.

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Fungal infection in the intensive care unit

Flanagan

Barnes

1998

Journal of Hospital Infection

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Hemofiltration: treating and preventing infection

Cited by 6 publications

References 53 publications

The diagnosis of ventilator-associated pneumonia using non-bronchoscopic, non-directed lung lavages

The diagnosis of ventilator-associated pneumonia using non-bronchoscopic, non-directed lung lavages

Melatonin ameliorates anxiety and depression‐like behaviors and modulates proteomic changes in triple transgenic mice of Alzheimer's disease

Fungal infection in the intensive care unit

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