Hemoglobin, C-reactive protein and ferritin in patients with oral carcinoma and their clinical significance – A prospective clinical study

Blatt, Sebastian; Schön, Holger; Sagheb, Keyvan; Kämmerer, Peer W.; Schiegnitz, Eik

doi:10.1016/j.jcms.2017.12.002

Cited by 12 publications

(17 citation statements)

References 26 publications

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“…Some investigators studied CRP in conjunction with other parameters. The study by Blatt revealed that CRP, hemoglobin, and ferritin could be used as biomarkers in prognosis and disease progression [ 57 ]. In the study by Park, the increased CRP/albumin ratio was associated with disease extension and a low survival rate, proving to be an accessible and useful marker for prognosis [ 58 ].…”

Section: Markers Of Inflammation In Osccmentioning

confidence: 99%

Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Tampa

Mitran

et al. 2018

Journal of Immunology Research

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Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflammation, strong evidence supporting the association between chronic inflammation and carcinogenesis. Moreover, an increasing number of studies have investigated the role of different mediators of inflammation in the early detection of OSCC. In this review, we have summarized the main markers of inflammation that could be useful in diagnosis and shed some light in OSCC pathogenesis.

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Section: Markers Of Inflammation In Osccmentioning

confidence: 99%

Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Tampa

Mitran

et al. 2018

Journal of Immunology Research

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“…Another major risk factor is chronic infections with human papillomavirus (HPV) and the presence of oral precursor lesions [10]. Since the prognosis for early-stage tumors is much better than for advanced stages, early detection is of central importance and several early detection methods and techniques have been advocated [11][12][13][14]. Even so, at present, there is no specific biomarker to detect precursor lesions and early stages of oral cavity carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Consequences of the COVID-19 Pandemic and Governmental Containment Policies on the Detection and Therapy of Oral Malignant Lesions—A Retrospective, Multicenter Cohort Study from Germany

Heimes

Müller

Schellin

et al. 2021

Cancers

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(1) Background: In response to the global COVID-19 pandemic, governmental measures have been undertaken. The impact of the crisis on the healthcare of patients with cancer is largely unexplored. This multicenter cohort study aimed to investigate a potential screening delay and its consequences in patients with oral cancer (OC) during the pandemic. (2) Material and Methods: Data of patients who were first diagnosed with OC during different periods were collected, especially in terms of OC incidence, tumor stage/entity and time to intervention. The periods lockdown (LD) (13 March–16 June 2020), post-lockdown (PLD) (17 June–1 November 2020), and the corresponding equivalents in 2018/19 were differentiated and compared. (3) Results: There was no obvious trend towards a higher incidence of OC or higher tumor stages, whereas a trend towards a shorter time to intervention during the LD2020 could be observed. Subgroup analyses revealed an increased incidence in OC within the PLD2020 in Mainz, which might be explained by the partial closure of dental practices in this federal state during LD. (4) Conclusions: While there was no overall higher incidence of OC, we found closure of practices during LD to possibly delay cancer diagnosis. Therefore, measures must be taken to identify patients at risk and to ensure basic healthcare, especially in the context of dental screening measures.

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“…There is a correlation between CRP levels and disease prognosis.In the study by Park et al, an increased CRP/ albumin ratio was correlated with prolonged disease and decreased survival rate (17) . Blatt et al noted that CRP, ferritin, and hemoglobin can be used as biomarkers in diagnosis and disease progression (18) . The same idea is supported by Tai et al in patients with oral squamous cell carcinoma (OSCC), which they showed a positive association between high CRP levels and oral cancer, and revealed that CRP level was associated with invasion of localized lymph nodes (19) .…”

Section: Discussionmentioning

confidence: 99%

Salivary levels of Interleukin-6, Interleukin-8 and Tumor Necrosis Factor-alpha in Smokers Aged 35-46 Years with Dental Caries Disease

2020

MLU

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Introduction: Dental caries is one of the most common infectious diseases prevalent in the oral cavity, and it is an inflammatory disease with a multi-factor etiology. IL-6, IL-8, and TNF-α are two types of cytokines that are major mediators of acute inflammation, and are necessary for the development of specific immune responses.Objective: The present study aimed to assess the level of pro-inflammatory cytokines (IL-6,IL-8,and TNF-α) in the saliva of smokers with dental caries and the control (non-smokers) according to different age, BMI,and sex. Materials and Method:Whole saliva from 32 smokers aged 35-46 years with dental caries and 16 healthy subjects, to measure IL-6,IL-8, and TNF-a levels by enzyme immunoassay (ELISA). Results:The mean BMI, age, and sex between the experimental group and the control group were similar, were not statistically significant (p=0.466, p=0.240, p=0.455), respectively while, there were a significant difference in CRP between the two groups (p=0.037).Concentrations of salivary IL-6, IL-8 and TNF-α were not affected by periodontal health. No statistically significant difference in periodontal health, assessed by CPITN, were observed between the groups (p=0.413). Salivary levels of IL-6 and IL-8 were significantly higher in smokers with dental caries compared with control (p<0.05).Salivary levels of IL-6 and IL-8 were increased significantly in smokers with dental caries compared with control (p<0.05). No significant differences in salivary TNF-α in dental caries patients compared to control (p=0.063). The correlation between TNF-a, CRP, age, sex, and BMI with IL-8 were positive and statistically significant(p=0.01, p=0.036, p=0.009, p=0.007, and p=0.005), respectively. Th ere was no significant correlation between IL-6 and TNF-a cytokines and other parameters, except for a positive association with CRP levels (p=0.006, p=0.043), respectively. Conclusions:These data indicate links between production of tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), and Interleukin-8 (IL-8)in smokers' saliva and dental caries disease. Also,the existence of a statistically significant positive correlation between TNF-a,age, gender, and BMI with IL-8.

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Hemoglobin, C-reactive protein and ferritin in patients with oral carcinoma and their clinical significance – A prospective clinical study

Cited by 12 publications

References 26 publications

Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Consequences of the COVID-19 Pandemic and Governmental Containment Policies on the Detection and Therapy of Oral Malignant Lesions—A Retrospective, Multicenter Cohort Study from Germany

Salivary levels of Interleukin-6, Interleukin-8 and Tumor Necrosis Factor-alpha in Smokers Aged 35-46 Years with Dental Caries Disease

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