Hemoglobin enhances miRNA-144 expression and autophagic activation mediated inflammation of microglia via mTOR pathway

Wang, Zhenyu; Yuan, Bangqing; Fu, Fenlan; Huang, Shaokuan; Yang, Zhao

doi:10.1038/s41598-017-12067-2

Cited by 33 publications

(27 citation statements)

References 47 publications

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“…Serum high molecular weight (HMW) adiponectin could improve insulin sensitivity; however, it has been reported that hemoglobin levels are inversely associated with serum HMW adiponectin levels in community-based populations [ 37 ]. Furthermore, hemoglobin might upregulate miR-144 expression, leading to an inflammatory response of microglia [ 38 ]. Taken together, these findings indicate that the hemoglobin levels are associated with MetS.…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin concentration is associated with the incidence of metabolic syndrome

Yang

et al. 2021

BMC Endocr Disord

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Background An association between hemoglobin and metabolic syndrome (MetS) has been reported. However, the relationships between hemoglobin and individual MetS components remain unclear. Therefore, we investigated these associations at baseline and at the 3-year follow-up. Methods We enrolled 9960 middle-aged and elderly subjects (6726 women and 3234 men) and performed a 3-year follow-up cohort study. All subjects completed a questionnaire and underwent anthropometric measurements and laboratory tests. Logistic regression models were developed to assess the association between hemoglobin and MetS and its components. Results MetS was present in 45.1% of women and 41.4% of men at baseline. The hemoglobin concentration was positively correlated with SBP, DBP, TGs, WC, FPG, insulin, HOMA-IR, BMI and uric acid (p < 0.05). The mean hemoglobin concentration was higher in subjects with hypertension, high TGs, abdominal obesity or elevated FPG (p < 0.01). At follow-up, elevated hemoglobin correlated with an increased incidence and ORs for MetS, high TGs, low HDL-c, hyperuricemia and NAFLD but not abdominal obesity, BP or FPG in women. Increased hemoglobin corresponded with an increased incidence and ORs for MetS, abdominal obesity, low HDL-c, hyperuricemia and NAFLD but not BP, high TGs or FPG in men. Conclusions Hemoglobin may play a role in predicting new-onset MetS in both women and men. Hemoglobin was notably correlated with future risk of high TGs, low HDL-c, hyperuricemia, and NAFLD among women and abdominal obesity, low HDL-c, hyperuricemia, and NAFLD among men.

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Section: Discussionmentioning

confidence: 99%

Hemoglobin concentration is associated with the incidence of metabolic syndrome

Yang

et al. 2021

BMC Endocr Disord

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“…A number of studies have demonstrated that miRNA-mediated autophagy and modulation of inflammation play an important part in disease progression. 18 , 19 , 20 Bioinformatics analysis ( http://www.targetscan.org/ ) found that miR-93-5p targets Toll-like receptor 4 (TLR4) and Atg7, suggesting that the expression of miR-93-5p plays an important role in the regulation of autophagy and inflammation.…”

Section: Introductionmentioning

confidence: 99%

miR-93-5p-Containing Exosomes Treatment Attenuates Acute Myocardial Infarction-Induced Myocardial Damage

Liu

Jiang

Deng

et al. 2018

Molecular Therapy - Nucleic Acids

166

114

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Adipose-derived stromal cells (ADSCs) have been considered as an attractive therapeutic tool. Accumulating evidence indicates that the healing effects of ADSCs are mainly related to paracrine action rather than transdifferentiation. Data show that the expression of miR-93-5p has a cardio-protective effect after acute myocardial infarction (AMI). To identify whether miR-93-5p-encapsulating exosomes that form ADSCs have a better cardio-protective effect, we investigated the inflammatory factors and miR-30d-5p expression in clinical levels. A rat model of AMI and an in vitro model of hypoxic H9c2 cells were established to study the protective mechanism of miR-93-5p in ischemia-induced cardiac injury. The results show that the expression of inflammatory cytokines and miR-93-5p were increased following AMI in both patients and animal models. Moreover, treatment with ADSC-derived miR-93-5p-containing exosomes has a greater protective effect on infarction-induced myocardial damage than simple exosome processing. Furthermore, in vitro experiments confirmed that the expression of miR-93-5p can significantly suppress hypoxia-induced autophagy and inflammatory cytokine expression by targeting Atg7 and Toll-like receptor 4 (TLR4), respectively, and was confirmed with Atg7 or TLR4 overexpression. The results also show that autophagy activation can promote inflammatory cytokine expression indirectly. Taken together, these results suggest that the miR-93-5p-enhanced ADSC-derived exosomes prevent cardiac injury by inhibiting autophagy and the inflammatory response.

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“…miRNAs control biological events either by triggering the degradation of their target mRNAs through recognition of specific sequences, miRNA response elements (MREs), in the 3' UTR, and/or through inhibition of their translation. Recent reports have provided evidence that under stress conditions, a number of miRNAs, including Mir144 [34], Mir142, Mir106, Mir93, and Mir20, are capable of modulating autophagy by changing the intracellular levels of key autophagy proteins. Mir223 plays roles in monocytes/ macrophages and embryonic stem cell differentiation, osteoclast formation, and bone remodeling.…”

Section: Introductionmentioning

confidence: 99%

Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1

et al. 2018

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3-MA: 3-methylademine; ACTB/β-actin: actin, beta; ATG: autophagy related; ATG16L1: autophagy related 16-like 1 (S. cerevisiae); BECN1: beclin 1, autophagy related; CNR2: cannabinoid receptor 2 (macrophage); CNS: central nervous system; CQ: chloroquine; EAE: experimental autoimmune encephalomyelitis; FOXO3: forkhead box O3; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; H&E: hematoxylin and eosin; ITGAM: integrin alpha M; LPS: lipoplysaccharide; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; miRNAs: microRNAs; MS: multiple sclerosis; PPARG: peroxisome proliferator activated receptor gamma; PTPRC: protein tyrosine phosphatase, receptor type, C; RA: rheumatoid arthritis; SQSTM1: sequestosome 1; TB: tuberculosis; TIMM23: translocase of inner mitochondrial membrane 23; TLR: toll-like receptor.

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Hemoglobin enhances miRNA-144 expression and autophagic activation mediated inflammation of microglia via mTOR pathway

Cited by 33 publications

References 47 publications

Hemoglobin concentration is associated with the incidence of metabolic syndrome

Hemoglobin concentration is associated with the incidence of metabolic syndrome

miR-93-5p-Containing Exosomes Treatment Attenuates Acute Myocardial Infarction-Induced Myocardial Damage

Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1

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