Hemoglobin Trend in Individuals Undergoing regular Hemodialysis—A retrospective Study from a Tertiary care Hospital

Nayak, Megha Nagaraj; Attur, Ravindra Prabhu; Veena, N. K.

doi:10.5958/0976-5506.2019.01011.8

“…The pooled proportion of sessions with IDHTN was 19.9% [(95% 12.5-28.6%, n = 8 studies, I 2 = 99.3%, p<0.001 for heterogeneity)] with significant differences across the different definition criteria (S1 Fig) . The p-value for the Begg test was 0.85, and the corresponding funnel plot corroborates the suggestion of no publication bias (S2 Fig) . There was no significant difference in the pooled prevalence of IDHTN for studies with median pre-dialysis SBP greater than 147.2mmHg [29.4% (95% CI 19.5-40.4%)] compared to the pooled prevalence of studies with pre-dialysis SBP less than or equal to 147.2mmHg PLOS ONE PLOS ONE Leave-one-out meta-analysis showed a maximum IDHTN pooled prevalence deviation of 2.0%, seen when Nayak et al [48] were omitted from the list of pooled studies (S7 Fig).…”

Section: Prevalence Of Idhtnmentioning

confidence: 95%

The prevalence and risk of mortality associated with intradialytic hypertension among patients with end-stage kidney disease on haemodialysis: A systematic review and meta-analysis

Adejumo,

Edeki,

Oyedepo

et al. 2024

PLoS ONE

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Introduction Intradialytic hypertension (IDHTN) is a common but less frequently recognised complication of haemodialysis. However, it is associated with increased overall mortality in patients on haemodialysis. This systematic review and meta-analysis aimed to determine the prevalence of IDHTN and associated mortality risk in the global haemodialysis population. Method A systematic search of PubMed and EMBASE was undertaken to identify articles with relevant data published between 1990 and 2023. The pooled prevalence of IDHTN in the global haemodialysis population was determined using the DerSimonian-Laird random-effects meta-analysis. The pooled hazards ratio for mortality in patients with IDHTN was also computed from the studies that reported mortality among haemodialysis patients with IDHTN. The study protocol was registered with PROSPERO (CRD42023388278). Results Thirty-two articles from 17 countries were included, with a pooled population of 127,080 hemodialysis patients (median age 55.1 years, 38.2% females). Most studies had medium methodological quality (53.1%, n = 17). The overall pooled prevalence of IDHTN was 26.6% [(95% CI 20.2–33.4%), n = 27 studies, I2 = 99.3%, p<0.001 for heterogeneity], with significant differences depending on the definition used. The pooled proportion of haemodialysis sessions with IDHTN was 19.9% [(95% 12.5–28.6%, n = 8 studies, I2 = 99.3%, p<0.001 for heterogeneity)] with significant differences across the different definition criteria. The p-value for the Begg test was 0.85. The median pre-dialysis blood pressure was not significantly associated with IDHTN. The pooled hazard ratio for mortality was 1.37 (95% CI 1.09–1.65), n = 5 studies, I2 = 13.7%, and p-value for heterogeneity = 0.33. Conclusion The prevalence of IDHTN is high and varies widely according to the definition used. A consensus definition of IDHTN is needed to promote uniformity in research and management. The increased mortality risk forecasted by IDHTN highlights the need for optimal blood pressure control in patients on hemodialysis.

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“…The pooled proportion of sessions with IDHTN was 19.9% [(95% 12.5-28.6%, n = 8 studies, I 2 = 99.3%, p<0.001 for heterogeneity)] with significant differences across the different definition criteria (S1 Fig) . The p-value for the Begg test was 0.85, and the corresponding funnel plot corroborates the suggestion of no publication bias (S2 Fig) . There was no significant difference in the pooled prevalence of IDHTN for studies with median pre-dialysis SBP greater than 147.2mmHg [29.4% (95% CI 19.5-40.4%)] compared to the pooled prevalence of studies with pre-dialysis SBP less than or equal to 147.2mmHg PLOS ONE PLOS ONE Leave-one-out meta-analysis showed a maximum IDHTN pooled prevalence deviation of 2.0%, seen when Nayak et al [48] were omitted from the list of pooled studies (S7 Fig).…”

Section: Prevalence Of Idhtnmentioning

confidence: 95%

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“…The pooled proportion of sessions with IDHTN was 19.9% [(95% 12.5-28.6%, n = 8 studies, I 2 = 99.3%, p<0.001 for heterogeneity)] with significant differences across the different definition criteria (S1 Fig) . The p-value for the Begg test was 0.85, and the corresponding funnel plot corroborates the suggestion of no publication bias (S2 Fig) . There was no significant difference in the pooled prevalence of IDHTN for studies with median pre-dialysis SBP greater than 147.2mmHg [29.4% (95% CI 19.5-40.4%)] compared to the pooled prevalence of studies with pre-dialysis SBP less than or equal to 147.2mmHg PLOS ONE PLOS ONE Leave-one-out meta-analysis showed a maximum IDHTN pooled prevalence deviation of 2.0%, seen when Nayak et al [48] were omitted from the list of pooled studies (S7 Fig).…”

Section: Prevalence Of Idhtnmentioning

confidence: 95%

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Hemoglobin Trend in Individuals Undergoing regular Hemodialysis—A retrospective Study from a Tertiary care Hospital

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The prevalence and risk of mortality associated with intradialytic hypertension among patients with end-stage kidney disease on haemodialysis: A systematic review and meta-analysis

The prevalence and risk of mortality associated with intradialytic hypertension among patients with end-stage kidney disease on haemodialysis: A systematic review and meta-analysis

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