Hemoglobinopathies in the Sudan

Abstract

In a prospective study, we evaluated hematological parameters in freshly obtained venous blood samples from 632 Sudanese patients attending the outpatient department at Khartoum Teaching Hospital, Khartoum, Sudan, in the period between March and July 2005. The patients were surveyed for full blood count (FBC) and hemoglobin (Hb) electrophoresis using a cellulose acetate method. Hb S [beta6(A3)Glu-->Val] was the most common abnormal Hb, which was not unexpected because the subjects live in the center of a malaria-affected area. The study showed low hematological parameters due to various causes including poor nutrition as well as infections and hemolytic processes.

Reference Value Profile for Healthy Individuals From the Aljouf region of Saudi Arabia

“…Similar results of MCV, WBC, Hb, PCV and RBC with varying degrees have been made in studies carried out in other ethnic groups such as Palestine [21], Tanzania [19], Sudan [28], Kenya [29], Nigeria, and Turkey [30].…”

“…Our findings reflect that healthy adults from the Aljouf region have also some hematological parameters differing quantitatively from Arab [19,21], Caucasians [25,26], Asian [23,27] and African [20,28,29], while other hematological parameters have reference value profiles which are similar to these ethnic groups [18,20,21,23,26,27,29].…”

Molecular analysis of the β‐globin gene cluster haplotypes in a Sudanese population with sickle cell anaemia

“…Previously published studies indicate that Hb S is common among Sudanese tribes, particularly in the Western regions (Kordofan and Darfur). Furthermore, haemoglobinopathies are also known to be prevalent in the Blue Nile and Northern tribes (Elderdery et al. , 2008).…”

“…Hb S is the variant of Hb most commonly found in Sudan where SCA is a particular problem (Bayoumi, Taha & Saha, 1985; Elderdery et al. , 2008).…”

Familial congenital cyanosis caused by Hb-M Yantai (α-76 GAC → TAC, Asp → Tyr)

“…The activity of cytochrome b5 reductase was measured spectrophotometrically by monitoring NADH oxidation (via ferricyanide reduction) at 340 nm (Haymond et al , 2005). Hemoglobin electrophoresis was performed on cellulose acetate (Elderdery et al , 2008), and the ratio of a fast-moving band (Hb-X) relative to Hb-A was defined using AlphaEaseFC software (Alpha Innotech, USA).…”