Hemolytic and Anti Microbial Effect in the Leaves of Acanthus ilicifolius

Thirunavuk, P.; Ramanathan, T.; Ramkumar, L.

doi:10.3923/jpt.2011.196.200

Cited by 11 publications

(6 citation statements)

References 6 publications

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“…Literature studies have reported that the chemical compounds (like bioactive or secondary metabolite) in Jeruju (A. ilicifolius) function as a neuralgic, analgesic, anti-inflammatory, antioxidant, hepatoprotective, antileukemic, anticancer, antimicrobial, antiviral, antifungal, and natural insecticide (Irawanto et al, 2015). Jeruju leaf extract could inhibit pathogenic bacteria growth, such as Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa (Khajure and Rathod, 2010), Escherichia coli, Klebsiella pneumoniae, Salmonella typhi (Chundakkadu et al, 2011), Staphylococcus epidermis (Govindasamy and Arulpriya, 2013), Proteus vulgaris, Streptococcus pneumoniae (Ravikumar et al, 2012), Streptococcus viridans (Pringgenies et al, 2020), Vibrio cholerae (Thirunavukkarasu et al, 2011a), and Vibrio harveyi (Saptiani et al, 2013;Sreenivasa et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Metabolomic profiling of Jeruju (Acanthus ilicifolius) leaf extract with antioxidant and antibacterial activity on Aeromonas hydrophila growth

Aisiah¹,

Rini²,

Tanod³

et al. 2022

j app pharm sci

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Jeruju (Acanthus ilicifolius) is a Kalimantan tidal swamp plant that is potent to treat Aeromonas hydrophila infection. This study aimed to determine the potential of Jeruju leaf extract as antioxidant and antibacterial agents to inhibit A. hydrophila growth. The research method included the sampling of Jeruju leaves in South Kalimantan, Indonesia. Then, the extracted sample was macerated with ethanol. The sample extracts were screened for phytochemical (Harborne) and metabolomic profiles (liquid chromatography and high-resolution mass spectrometry). The profile of compounds in the extract predicted biological activity using PASS server. Furthermore, the extracts were assayed for antibacterial activity (well diffusion and broth dilution), antioxidant activity 2,2-diphenyl-1-picrylhydrazyl (DPPH), and total phenol content (Folin-Ciocalteu). The phytochemical screening showed that the Jeruju leaves' ethanol extract contained alkaloids, flavonoids, tannins, phenolics, terpenoids, and steroids. The metabolomic profiling was dominated by betaine (41.61%) and choline (40.27%). The prediction of biological activity showed that the Jeruju leaf extract acted as a peptidoglycan glycosyltransferase enzyme inhibitor, DNA synthesis inhibitor, and free radical scavenger. The Jeruju leaf extract can inhibit A. hydrophila growth on glutamate starch phenol agar (9.09%). The ethanol extract of Jeruju leaves showed very strong antioxidant potential (IC 50 = 49.73 ± 1.14 µg/ml and 70.31% DPPH scavenging effect at 96 µg/ml), with a total phenol content of 32,667 ± 1,778.58 mg Gallic acid equivalent (GAE)/100 g dry extract. These research findings provide potential antioxidant and antibacterial activities for Jeruju (A. ilicifolius) leaves' ethanol extract for inhibiting A. hydrophila growth.

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Section: Introductionmentioning

confidence: 99%

Metabolomic profiling of Jeruju (Acanthus ilicifolius) leaf extract with antioxidant and antibacterial activity on Aeromonas hydrophila growth

Aisiah¹,

Rini²,

Tanod³

et al. 2022

j app pharm sci

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“…The chloroform extract was then stored in a refrigerator for future use. 20 Treatment using A. ilicifolius chloroform extract 8% (Group AI-1), 16% (Group AI-2) and Nystatin as control groups was performed by applying 0.5 cc of the material to the surface of the tongue at the same time on 14 consecutive days, after which the subjects in each group were sacrificed and biopsed. TLR-2 expression was examined using a immunohistochemical staining method and then observed by means of a light microscope at 400x magnification.…”

Section: Methodsmentioning

confidence: 99%

The effects of Acanthus ilicifolius chloroform extract on TLR-2 expression of macrophages in oral candidiasis

Andriani

Pargaputri

2018

Dent. J.

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Background: Immunosuppressed conditions due to long-term corticosteroid and tetracycline consumption are susceptible to fungal invasion, especially by Candida albicans (C. albicans), that requires treatment of oral candidiasis. Toll like receptor-2 (TLR-2) plays a role in candida recognition. Nystatin is regularly employed for oral candidiasis, but produces certain side-effects. Chloroform extract of Acanthus ilicifolius (A. ilicifolius) leaves represents both a potent inhibitor of C. albicans growth and an antioxidant. Purpose: This study aimed to compare the effect of A. ilicifolius leaf chloroform extract and nystatin treatment on TLR-2 expression in oral candidiasis immunosupressed models. Methods: This study constitutes a true experimental investigation incorporating a post test-only control group design. 20 healthy male Rattus novergicus (Wistar), aged 12 weeks and with an average weight of 250g, were immunosuppressed through oral administration of dexamethasoneand tetracycline for a period of 21 days before being induced with C. albicans (ATCC-10231) 6 x 108 for two weeks. The subjects were divided into five groups (n=4/group): healthy (H), no-treatment(P), nystatin treatment(N), A. Ilicifollius (8%) treatment (AI-1) and A. ilicifollius (16%) treatment (AI-2). The subjects were treated for 14 days, with their tongue being subsequently biopsied. TLR-2 expression was subjected to immunohistochemical examination, observed under a microscope (400x magnification) and statistically analyzed (one-way Anova, LSD-test, p<0.05). Results: TLR-2 expression of P (6.25 ± 2.5), N (11.25 ± 0.96), AI-1 (13.00 ± 1.15), AI-2 (12.75 ± 1.7) was higher than H (1.75 ± 0.5). Significant differences existed between N to P, N, AI-1, AI-2; P to N, AI-1 and AI-2 (p<0.05). No significant differences were present between N, AI-1 and AI-2 (p < 0.05). Conclusion: A. ilicifolius extract can increase expression of TLR-2 in oral Candidiasis-immunosuppressed models. A. ilicifolius extract produces the same effect in increasing TLR-2 expression when compared to nystatin.

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“…The sand dune fl ora is an extremely essential resource in the healing, therapeutic, and economic [7]. The medications acquired from the ocean have the chance of exploiting in medication since it has enormous antiviral, antimicrobial, and anticancer activities [8].…”

Section: Applications Of Coastal Sand Dunes Vegetationsmentioning

confidence: 99%

“…The medications acquired from the ocean have the chance of exploiting in medication since it has enormous antiviral, antimicrobial, and anticancer activities [8]. The applications of coastal sand dunes include nutrients, feed, manure, fl ooder, nourishment, drug, fi rm and social uses [7]. Coastal sand dunes have been accounted for to contain a greater assortment of horticultural, agronomical, industrial, pharmaceutical, and chemically signifi cant microorganisms [6].…”

Section: Applications Of Coastal Sand Dunes Vegetationsmentioning

confidence: 99%

“…Sida cordifoliaAlkaloids and phytosterols HSV I & II, HSV TK, Adenovirus type VIII, Poliovirus type-I, Infl uenza virus type A (H1N1)Galal, et al 2015[78] Spinifex littoreus Flavonoids and terpenoid, polyisoprenoids AIDS Thirunavukkarasu, et al 2010[7] Suaeda maritima N-methyl-2,3,4-trimethoxy coricidin, fl avonoid and terpenoid Tobacco mosaic virus (TMV), HSV-1 Kokila and Anup, 2010[79] …”

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confidence: 99%

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A comprehensive overview of the pharmaceutical properties of Indian coastal sand dune flora: Emphasis on anti-virals

Saravanakumar¹,

Arjun²,

Jency³

et al. 2023

Ann Antivir Antiretrovir

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Viral infections have an essential function in both humans and other organisms. The persistent rise in viral diseases has made critical damage to human well-being. The present review indicates that viral diseases are been entangled in various cancer developments. Developing safe and effective antiviral medications remains a challenge. As a result, finding therapeutic targets that would interfere with the virus without affecting the host is hard-hitting. The use of natural substances rather than chemicals in the formulation of antiviral medications could significantly minimize the risk of side effects in patients. Coastal dune vegetation is a vital resource, which plays an imperative part in biodiversity. Coastal dunes have various utilizations in restorative and drug development. The drugs from marine are vitally been utilized as medicine due to their substantial antiviral, anticancer, and antimicrobial activities. Though Coastal dunes flora has numerous possessions their antiviral properties are rarely reported. Hence, in this report, we have compiled and highlighted the antiviral properties of 128 Indian coastal dune flora. This review may provide access to a profound understanding of coastal dunes’ vegetation resources and their usage in the production of antiviral and anticancer drugs. It may also help to preserve and cultivate these plants.

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Hemolytic and Anti Microbial Effect in the Leaves of Acanthus ilicifolius

Cited by 11 publications

References 6 publications

Metabolomic profiling of Jeruju (Acanthus ilicifolius) leaf extract with antioxidant and antibacterial activity on Aeromonas hydrophila growth

Metabolomic profiling of Jeruju (Acanthus ilicifolius) leaf extract with antioxidant and antibacterial activity on Aeromonas hydrophila growth

The effects of Acanthus ilicifolius chloroform extract on TLR-2 expression of macrophages in oral candidiasis

A comprehensive overview of the pharmaceutical properties of Indian coastal sand dune flora: Emphasis on anti-virals

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