Hemolytic Anemia Associated with Cold Agglutinin During Chickenpox and a Review of the Literature

Terada, K.; Tanaka, Haruki; Mori, Ryan; Kataoka, Naoki; Uchikawa, Makoto

doi:10.1097/00043426-199803000-00012

Cited by 31 publications

(20 citation statements)

References 6 publications

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“…For the current patient, drug reactions and autoimmune diseases were ruled out and post-infectious autoimmune reaction secondary to chickenpox was suspected. Association of varicella infection with AIHA is well established; however, there is only one patient with accompanying hepatitis in the literature (10,11). Moreover, histological confirmation highlighted the nature of the hepatitis in our patient.…”

Section: Discussionsupporting

confidence: 47%

Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox

Baran

Özgenç²,

Berk³

et al. 2010

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 47%

Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox

Baran

Özgenç²,

Berk³

et al. 2010

Turk J Gastroenterol

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“…Postinfectious cold agglutinins are seen with viral and bacterial pathogens, including mycoplasma, 19 Epstein-Barr virus, [20][21][22] and legionella. Case reports of cold agglutinin hemolysis induced by varicella, [23][24][25] Citrobacter, 26 and influenza 27,28 have been described. Polyclonal IgM antibodies are most commonly seen in children.…”

Section: History and Mechanismmentioning

confidence: 99%

Cold agglutinin disease

Swiecicki

Hegerova

Gertz

2013

Blood

266

298

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Cold agglutinin disease is a rare and poorly understood disorder affecting 15% of patients with autoimmune hemolytic anemia. We reviewed the clinical and pathologic features, prognosis, and management in the literature and describe our institutional experience to improve strategies for accurate diagnosis and treatment. Retrospective analysis identified 89 patients from our institution with cold agglutinin disease from 1970 through 2012. Median age at symptom onset was 65 years (range, 41 to 83 years), whereas the median age at diagnosis was 72 years (range, 43 to 91 years). Median survival of all patients was 10.6 years, and 68 patients (76%) were alive 5 years after the diagnosis. The most common symptom was acrocyanosis (n = 39 [44%]), and many had symptoms triggered by cold (n = 35 [39%]) or other factors (n = 20 [22%]). An underlying hematologic disorder was detected in 69 patients (78%). Thirty-six patients (40%) received transfusions during their disease course, and 82% received drug therapy. Rituximab was associated with the longest response duration (median, 24 months) and the lowest proportion of patients needing further treatment (55%). Our institution’s experience and review of the literature confirms that early diagnostic evaluation and treatment improves outcomes in cold agglutinin disease.

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“…19 It can also be detected in lymphoproliferative diseases and other infectious diseases such as rubella, varicella, mononucleosis and cytomegalovirus. 19,20 The link between AIHA and systemic lupus erythematosus (SLE), although infrequent, is also well- In general, patients with AIHA exhibit normal granulocyte and platelet series. The combination of AIHA with immune thrombocytopenia immune, concurrently or sequentially, can, however, occur.…”

Section: Resultsmentioning

confidence: 99%

Curso clínico da anemia hemolítica auto-imune: um estudo descritivo

Oliveira¹,

Oliveira²,

Murao³

et al. 2006

J. Pediatr. (Rio J.)

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Objective: Autoimmune hemolytic anemia is characterized by the production of autoantibodies against erythrocyte membrane antigens. This study was carried out to identify the clinical, immunological and outcome characteristics of autoimmune hemolytic anemia patients treated at the (HC-UFMG) Pediatric Hematology Unit and the Hemocentro de Belo Horizonte. Methods:We evaluated 17 patients younger than 15 years old admitted from 1988 to 2003 were evaluated. Autoimmune hemolytic anemia diagnosis was based on the presence of acquired hemolysis and confirmed by positive direct Coombs polyspecific test results. Clinical, laboratory, and outcome data were obtained from patient records. Results:The median age at diagnosis was 10.5 months. The direct Coombs polyspecific test was positive in 13 and negative in four patients. Monospecific testing was performed for 14 patients. The most frequent red cell autoantibody was IgG (five patients), followed by IgM in two. Thirteen patients had severe anemia and needed blood transfusions. Underlying diseases were identified in four patients: systemic lupus erythematosus, Hodgkins lymphoma, autoimmune hepatitis and Langerhans cell histiocytosis. The remaining patients were classified as having primary disease. The median follow-up period was 11 months (5 to 23 months). Three children died, two after splenectomy and one with complications of the underlying disease. Conclusion:Autoimmune hemolytic anemia is rare in children and adolescents. Although patients usually respond to corticosteroids and/or immunoglobulin, fatal cases can occur. Prognosis is worse in patients with chronic underlying diseases.

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Hemolytic Anemia Associated with Cold Agglutinin During Chickenpox and a Review of the Literature

Cited by 31 publications

References 6 publications

Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox

Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox

Cold agglutinin disease

Curso clínico da anemia hemolítica auto-imune: um estudo descritivo

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