Hemopatch® is effective and safe to use: real-world data from a prospective European registry study

Abstract

Surgical procedures are often impeded by bleeding and/or leakage of body fluids. These complications cannot always be resolved by conventional surgical techniques. Hemopatch® is a hemostatic patch that also functions as a sealant. Here we document the effectiveness and safety of Hemopatch® for routine procedures of multiple surgical disciplines. To this end, we performed a prospective, multicenter, single-arm, observational registry study. Patients were eligible if they had received Hemopatch® during an open or minimally invasive procedure in one of these specialties: hepatobiliary, cardiovascular, urological, neurological/spinal, general, or lung surgery. Patients were excluded if they had a known hypersensitivity to bovine proteins or brilliant blue, intraoperative pulsatile or severe bleeding and/or infection at the target application site (TAS). The primary endpoint for intraoperative effectiveness was hemostasis assessed as the percentage of patients achieving hemostasis within 2 min and the percentage of patients achieving hemostasis without re-bleeding at the time of surgical closure. The registry enrolled 621 patients at 23 study sites in six European countries. Six hundred twenty patients had completed follow-up information. Hemostasis within 2 min was achieved at 463 (74.5%) of all 621 TASs. Hemostasis without re-bleeding was observed at 620 (99.8%) TASs. Adverse events were reported in 64 patients (10.3%). This Hemopatch® registry shows that Hemopatch® efficiently establishes hemostasis and sealing in a variety of surgical specialties, including minimally invasive procedures. Furthermore, we provide evidence for the safety of Hemopatch® across all the specialties included in the registry. This study is registered at clinicaltrials.gov: NCT03392662.

Real-World Data on the Usage of Hemopatch® as a Hemostat and Dural Sealant in Cranial and Spinal Neurosurgery

“…17-344 dated 11/8/2017). Details of the study design and selection of participants were reported previously [ 15 ]. In brief, the registry was designed as a prospective, multicenter, single-arm, observational study.…”

“…Perioperative data on the effectiveness and safety of Hemopatch ® as well as the potential use of bicarbonate was recorded with an electronic case report form (eCRF) [ 15 ].…”

“…Recently, data from a registry documenting the real-world clinical application of Hemopatch ® was published [ 15 ]. This registry was the largest carried out for this product so far and included cases from several surgical specialties such as hepatobiliary, pulmonary, neurological/spinal, urological, and general surgery.…”

“…This registry was the largest carried out for this product so far and included cases from several surgical specialties such as hepatobiliary, pulmonary, neurological/spinal, urological, and general surgery. In summary, this registry documented the effectiveness and safety of Hemopatch ® in achieving hemostasis and sealing in various tissues, not only in open procedures but also in minimally invasive surgery [ 15 ]. Here we report on specific outcomes from the neurological/spinal cohort of this registry (n=148).…”

“…a Minimally invasive surgery included cranial biopsies, mini-craniotomies, or craniotomies with endoscopic intervention or biopsies b Only patients with comorbidities CCI = Charlson Comorbidity Index Adapted from[15] …”