Hemoptysis as the Presenting Symptom in Bronchiolitis Obliterans Organizing Pneumonia

Mróz, Barbara; Sexauer, William; Meade, Arturo; Balsara, Gulnar

doi:10.1378/chest.111.6.1775

Cited by 32 publications

(19 citation statements)

References 7 publications

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“…The clinical symptoms of the study patients were in agreement with those previously reported [10,13,16]. However, OP may be present with non-typical clinical symptoms such as rapidly progressive life-threatening syndrome [23,24] or largequantity hemoptysis [25].…”

Section: Discussionsupporting

confidence: 90%

Organizing pneumonia: Manifestation peculiarities, causes, and outcomes

et al. 2011

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Section: Discussionsupporting

confidence: 90%

Organizing pneumonia: Manifestation peculiarities, causes, and outcomes

et al. 2011

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“…However, the quantity of blood was not described in these patients. Severe hemoptysis as the cardinal presenting manifestation of BOOP is extremely rare and has only been reported in 2 cases by Mroz et al [18]. Two of our patients had moderate hemoptysis and the others had minimal hemoptysis.…”

Section: Discussionmentioning

confidence: 50%

Bronchiolitis obliterans Organizing Pneumonia

Oymak

Demirbaş

Mavili³

et al. 2005

Respiration

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Background: Bronchiolitis obliterans organizing pneumonia (BOOP) may be classified as cryptogenic (idiopathic) and secondary. There are no clear clinical and radiological features distinguishing between idiopathic and secondary BOOP. Objectives: To analyze the etiologic factors, clinical and radiological features, diagnostic approach and response to therapy at onset and outcome in subjects with BOOP. Methods: The medical files of Erciyes University Hospital from 1995 to 2003 were retrospectively reviewed. Patients with biopsy-proven BOOP were selected for evaluation. The etiology and initial features of BOOP, treatment, resolution, relapse, and survival were obtained from medical records, and a follow-up patient questionnaire. Results: We have diagnosed 26 cases (13 males /13 females) with BOOP syndrome (mean age 54 ± 15 years, range 14–93). More than half the patients (58%) were classified as idiopathic BOOP. Patients presented with cough (92%), dyspnea (70%), pleuritic chest pain, hemoptysis and fever (50%). The biopsy specimens had been obtained by transbronchial and/or transthoracic lung biopsy in 18 cases (69%). At radiological evaluation, there were bilateral patchy alveolar and/or interstitial infiltrates in 16 patients (62%), and solitary pneumonic involvement in 10 patients (38%). Three patients recovered spontaneously, 5 remained cured after resection of the focal lesion. Corticosteroid therapy was given in 17 patients (65%). Apart from four patients who died (death was attributable to BOOP in only 1 patient) and three patients who relapsed, the prognosis was good in all patients. Conclusions: The etiology of BOOP is usually idiopathic. We observed that hemoptysis and pleuritic chest pain were a relatively frequent symptom in BOOP in the present series, in contrast to previous observations. The diversity of radiological and clinical presentations including hemotysis and pleuritic chest pain should prompt consideration of the diagnosis in patients with persisting pulmonary symptoms and radiological findings.

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“…Dyspnoea may occasionally be severe, especially in the eventuality of rapidly progressive disease. Haemoptysis is uncommon and seldom severe [105]. Other uncommon manifestations include chest pain, night sweats and mild arthralgia (when arthralgia is prominent and/ or associated with myalgia an underlying connective tissue disease should be suspected).…”

Section: Clinical Featuresmentioning

confidence: 99%

Cryptogenic organising pneumonia

Jf¹

2006

Eur Respir J

485

466

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Organising pneumonia is defined histopathologically by intra-alveolar buds of granulation tissue, consisting of intermixed myofibroblasts and connective tissue. Although nonspecific, this histopathological pattern, together with characteristic clinical and imaging features, defines cryptogenic organising pneumonia when no cause or peculiar underlying context is found. Rapid clinical and imaging improvement is obtained with corticosteroid treatment, but relapses are common after stopping treatment.

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Hemoptysis as the Presenting Symptom in Bronchiolitis Obliterans Organizing Pneumonia

Cited by 32 publications

References 7 publications

Organizing pneumonia: Manifestation peculiarities, causes, and outcomes

Organizing pneumonia: Manifestation peculiarities, causes, and outcomes

Bronchiolitis obliterans Organizing Pneumonia

Cryptogenic organising pneumonia

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