Hemorheological abnormalities in human arterial hypertension

Presti, Rosalia Lo; Hopps, Eugenia; Caimi, Gregorio

doi:10.1007/s13367-014-0021-5

Cited by 11 publications

(7 citation statements)

References 38 publications

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“…In addition, it has to be emphasized, while in normal controls and in VAD subjects without DM we found a significant positive correlation between PMN membrane fluidity and PMN cytosolic Ca 2+ concentration, this finding was not observed in the group of VAD subjects with type 2 DM [18]. The same results have been noted in hypertensive [20,21,22] and in CKD patients [23,24,25,26]. At baseline, in subjects with essential hypertension we found an increase in PMN cytosolic calcium content only.…”

Section: Chronic Clinical Conditionssupporting

confidence: 66%

Fluidity and cytosolic Ca2+ concentration of circulating polymorphonuclear leukocytes at baseline in some chronic and acute clinical conditions: review of our survey

Caimi¹,

Canino²,

Presti³

et al. 2016

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Abstract. Objective: In this mini-review we describe the behavior of polymorphonuclear leukocyte (PMN) membrane fluidity and of PMN cytosolic Ca 2+ concentration in some chronic and acute clinical conditions. Methods: PMN membrane fluidity was evaluated employing the fluorescent probe Fura-2AM, and PMN cytosolic Ca 2+ concentration was evaluated using the fluorescent probe TMA-DPH. Results: From the determination of these two parameters investigated on resting PMNs, an almost constant increase in PMN cytosolic Ca 2+ concentration in chronic clinical conditions, such as vascular atherosclerotic disease with and without diabetes mellitus, essential hypertension, chronic kidney disease, and diabetes mellitus of both types, and a decrease in PMN membrane fluidity in acute clinical conditions, such as juvenile acute myocardial infarction and acute ischemic stroke, are evident. Conclusion: The possible reasons for this different behavior are analyzed on the basis of pathophysiological considerations.

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Section: Chronic Clinical Conditionssupporting

confidence: 66%

Fluidity and cytosolic Ca2+ concentration of circulating polymorphonuclear leukocytes at baseline in some chronic and acute clinical conditions: review of our survey

Caimi¹,

Canino²,

Presti³

et al. 2016

Self Cite

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“…An elevated concentration of fibrinogen in plasma generates an abnormal increase in RBC aggregation, changing the rheological behavior of blood. Aggregation and its effect in blood rheology have been related to several diseases [160][161][162], such as inflammation, diabetes [80,163,164], hypertension [165], obesity [166] and coronary syndromes [167][168][169].…”

Section: Hemorheological Pathologies and Emergent Microfluidics Diagn...mentioning

confidence: 99%

Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology

et al. 2022

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In this article, we describe the general features of red blood cell membranes and their effect on blood flow and blood rheology. We first present a basic description of membranes and move forward to red blood cell membranes’ characteristics and modeling. We later review the specific properties of red blood cells, presenting recent numerical and experimental microfluidics studies that elucidate the effect of the elastic properties of the red blood cell membrane on blood flow and hemorheology. Finally, we describe specific hemorheological pathologies directly related to the mechanical properties of red blood cells and their effect on microcirculation, reviewing microfluidic applications for the diagnosis and treatment of these diseases.

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“…Chien and coworkers first accurately quantified altered blood viscosity with pathophysiological research 10 , 11 . Blood viscosity is now a known indicator of CVD 12 , peripheral arterial disease 13 , 14 , arterial hypertension 15 , diabetes mellitus 16 , high cholesterol and triglyceride levels 17 , and sickle-cell anemia 18 . In addition, there is a strong correlation between elevated RBC aggregation and inflammation 19 , 20 .…”

Section: Introductionmentioning

confidence: 99%

Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery

Hsu

Tsai

et al. 2018

Sci Rep

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Open heart surgeries are common for treating ischemic and heart valve disease. During cardiac surgery, cardiopulmonary bypass (CPB) can temporarily take over the function of heart and lungs. However, elevated red blood cell (RBC) aggregation may lead to the common side-effects such as microinfarction. We investigated blood physical properties changes and the correlation between blood microstructure, viscoelastic response and biochemical changes following surgery with CPB. We examined shear-rate dependent blood viscosity, elasticity and RBC aggregate size in the pre-surgery disease state, post-surgery state and long-term recovery state of cardiac surgical patients. Within a week following surgery, the patient hematocrit was significantly lower due to CPB. Despite lower RBC concentration, the RBC aggregate shape became larger and more rounded, which is correlated to the elevated plasma fibrinogen related to systemic inflammatory response. During the same period, the hematocrit-adjusted low shear rate viscosity increased significantly, as did the yield stress, indicating more solid-like behavior for blood. Six months to one year later, all the physical and biochemical properties measured returned to baseline.

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Hemorheological abnormalities in human arterial hypertension

Cited by 11 publications

References 38 publications

Fluidity and cytosolic Ca2+ concentration of circulating polymorphonuclear leukocytes at baseline in some chronic and acute clinical conditions: review of our survey

Fluidity and cytosolic Ca2+ concentration of circulating polymorphonuclear leukocytes at baseline in some chronic and acute clinical conditions: review of our survey

Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology

Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery

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