Hemorheological Parameters in Children With Iron-Deficiency Anemia and the Alterations in These Parameters in Response to Iron Replacement

Halis, Hülya; Bor-Küçükatay, Melek; Akın, Mehmet; Küçükatay, Vural; Bozbay, Ismail; Polat, Azız

doi:10.1080/08880010902754909

Cited by 16 publications

(7 citation statements)

References 16 publications

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“…However, iron treatment reverses the symptoms of anemia and may contribute to the regulation of blood flow by causing increments in the alterations observed in hemorheologic parameters during anemia. 21 The findings of Grossi et al, 22 demonstrating that anemia represented an apparent protective modifier for periodontal disease expression, provided a new observation that highlighted our lack of knowledge and generated new hypotheses for further testing. Excess iron might worsen gingival health, as iron is an essential element for bacteria, parasites, and neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Iron‐Deficiency Anemia and Periodontal Status in Female Patients

Enhoş

Duran

Erdem

et al. 2009

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Relationship Between Iron‐Deficiency Anemia and Periodontal Status in Female Patients

Enhoş

Duran

Erdem

et al. 2009

Journal of Periodontology

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“…Interestingly, a decrement of red blood cell deformability was found in patients with iron deficiency anemia, which was reversed to control values after iron therapy [27]. In addition, a recently published randomized control trial showed clinical improvement in patients with chronic heart failure and hypoferremia after a course of parenteral iron therapy regardless of the anemia status [28].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Red Cell Distribution Width in Predicting All-Cause Long-Term Mortality after Non-ST-Elevation Myocardial Infarction

Azab¹,

Torbey²,

Hatoum³

et al. 2011

Cardiology

102

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Background: Red blood cell distribution width (RDW) is a strong predictor of adverse outcomes in patients with heart failure, stable coronary artery disease, stroke and acute myocardial infarction. The aim of our study was to explore the predictive value of RDW on all-cause mortality in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Method: This observational study includes 619 NSTEMI patients, discharged from Staten Island University Hospital between September 2004 and December 2006. Patients were divided into equal RDW tertiles and survival was evaluated in each tertile. Result: Patients in the highest RDW tertile (RDW >14) had higher in-patient (7 vs. 1%) and 4-year (30 vs. 7%) mortality rates compared to those in the lowest tertile (RDW <13) (Wilcoxon χ² = 34.64, p < 0.0001). After controlling for Global Registry of Acute Coronary Events risk profile scores and other confounding variables, the RDW adjusted hazard ratio for 4-year all-cause mortality increased by 1.10 for each one unit increase in RDW (confidence interval 1.004–1.213, p = 0.042). Conclusion: RDW is an independent predictor of all-cause long-term mortality in NSTEMI patients. Further studies are needed to clarify the mechanisms of this association between RDW and adverse outcomes in patients with coronary artery disease.

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“…Depending on the type of anemia, changes in viscosity may be correlated with changes in deformability (79) or changes in RBC-mediated NO metabolism. For example, in hemolytic anemia, release of free Hb may lead to systemic NO scavenging, affecting vascular tone (71, 152).…”

Section: Rbc Dysfunction and Anemiamentioning

confidence: 99%

Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia

Kuhn

Diederich

Keller

et al. 2017

Antioxidants & Redox Signaling

344

250

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Significance: Recent clinical evidence identified anemia to be correlated with severe complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events, stroke, hypertension, arrhythmias, and inflammation, particularly in elderly patients. The underlying mechanisms of these complications are largely unidentified.Recent Advances: Previously, red blood cells (RBCs) were considered exclusively as transporters of oxygen and nutrients to the tissues. More recent experimental evidence indicates that RBCs are important interorgan communication systems with additional functions, including participation in control of systemic nitric oxide metabolism, redox regulation, blood rheology, and viscosity. In this article, we aim to revise and discuss the potential impact of these noncanonical functions of RBCs and their dysfunction in the cardiovascular system and in anemia.Critical Issues: The mechanistic links between changes of RBC functional properties and cardiovascular complications related to anemia have not been untangled so far.Future Directions: To allow a better understanding of the complications associated with anemia in CVD, basic and translational science studies should be focused on identifying the role of noncanonical functions of RBCs in the cardiovascular system and on defining intrinsic and/or systemic dysfunction of RBCs in anemia and its relationship to CVD both in animal models and clinical settings. Antioxid. Redox Signal. 26, 718–742.

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Hemorheological Parameters in Children With Iron-Deficiency Anemia and the Alterations in These Parameters in Response to Iron Replacement

Abstract: Iron treatment not only reverses the symptoms of anemia but also may contribute to blood flow regulation by causing increments in the alterations observed in hemorheological parameters during anemia.

Cited by 16 publications

References 16 publications

Relationship Between Iron‐Deficiency Anemia and Periodontal Status in Female Patients

Relationship Between Iron‐Deficiency Anemia and Periodontal Status in Female Patients

Usefulness of Red Cell Distribution Width in Predicting All-Cause Long-Term Mortality after Non-ST-Elevation Myocardial Infarction

Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia

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