Hemorrhagic cystitis with massive bleeding from nontyphoidal Salmonella infection: A case report

Abstract

Hemorrhagic cystitis is defined by lower urinary tract symptoms that include dysuria, hematuria, and hemorrhage and is caused by viral or bacterial infection or chemotherapeutic agents. Reports of hemorrhagic cystitis caused by non-typhoidal salmonella (NTS) are extremely rare.We report a case of a 41-year-old man with hemorrhagic cystitis from NTS that caused massive bleeding and shock. The patient was hospitalized for uncontrolled diabetes and obstructive uropathy related to severe cystitis. A urine culture was positive for group D NTS. This case demonstrated that hemorrhagic cystitis in a patient with a risk factor such as diabetes can be a manifestation of local extra-intestinal NTS infection.

Urocystitis and Ureteritis in Holstein Calves with Septicaemia Caused by Salmonella enterica Serotype Dublin

“…Urocystitis and urinary tract infection (UTI) caused by S. enterica subsp. enterica has been described in man (Tena et al, 2007;Na et al, 2013;Polat et al, 2014); however, descriptions in cattle are lacking. This work describes lower urinary tract lesions in four Holstein calves with septicaemia caused by S. Dublin.…”

“…It has been associated with old age, concomitant diseases such as diabetes mellitus, urolithiasis, urinary tract malformations, chronic disease or immunosuppressive therapy (Tena et al, 2007). Salmonella Enteritidis and S. Typhimurium are the serotypes most frequently isolated from people with UTI (Tena et al, 2007), although other non-typhoidal salmonellas and Salmonella Typhi have been implicated in cases of haemorrhagic cystitis (Na et al, 2013;Polat et al, 2014). Because people act as reservoirs only for S. Typhi and Salmonella Paratyphi, the occurrence of disease associated with non-typhoidal salmonellas suggests acquisition either from animal reservoirs or from contaminated animal products or foods (Na et al, 2013), so non-typhoidal salmonellosis is of great public health importance.…”

“…Salmonella Enteritidis and S. Typhimurium are the serotypes most frequently isolated from people with UTI (Tena et al, 2007), although other non-typhoidal salmonellas and Salmonella Typhi have been implicated in cases of haemorrhagic cystitis (Na et al, 2013;Polat et al, 2014). Because people act as reservoirs only for S. Typhi and Salmonella Paratyphi, the occurrence of disease associated with non-typhoidal salmonellas suggests acquisition either from animal reservoirs or from contaminated animal products or foods (Na et al, 2013), so non-typhoidal salmonellosis is of great public health importance. Cattle are a host-adapted species for S. Dublin and are considered a good experimental model for non-typhoidal salmonellosis in man (Costa et al, 2012).…”

Uncommon Haemorrhagic Cystitis of Infectious Origin: A Narrative Review for Urologists

“… 33 Among the most common bacterial causes of hemorrhagic cystitis Escherichia coli , Staphylococcus saprophyticus, Proteus spp, and Klebsiella spp can be found. 29 , 34 Non-typhoidal Salmonella (NST) 35 , 36 and Chryseobacterium indologenes are anecdotally reported as bacterial causes of haemorrhagic cystitis. 37 …”

Recurrent hemorrhagic shock from hemorrhagic cystitis due to neurogenic bladder

“…As we investigated, few cases of refractory hemorrhagic cystitis with subsequent hemorrhagic shock were reported in the past. 3 , 4 , 5 Chemotherapy and infection mainly cause severe hemorrhagic cystitis. At our hospital, 183 patients were diagnosed with hemorrhagic cystitis between 2009 and 2018.…”