“…There are different haemostatic techniques or materials to reduce bleeding. Some of these proposed agents to control bleeding in apical surgery are: bone wax (6-8), cellulose membranes (9-11), gelatine sponges (10,11), collagen agents (9,11), thrombin (10-12), chitosan (9,13), epinephrine (11,14,15), ferric sulphate (16-21), calcium sulphate (16) and aluminium chloride (14,15,18-21). Different articles have addressed haemostatic agents for apical surgery, but to date there isn’t any specific systematic review on this topic.…”