Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Baron, Raluca Ioana; Duceac, Ioana A.; Morariu, Simona; Bostănaru-Iliescu, Andra-Cristina; Coseri, Sergiu

doi:10.3390/gels8110726

Cited by 23 publications

(18 citation statements)

References 56 publications

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“…Baron et al [ 82 ] also used a pullulan composite for wound healing and drug delivery. Hydrogels made from oxidized pullulan and dopamine have possible applications in hemostatic wound dressing.…”

Section: Microbial Exopolysaccharide Composites and Their Applicationsmentioning

confidence: 99%

Microbial Exopolysaccharide Composites in Biomedicine and Healthcare: Trends and Advances

et al. 2023

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Microbial exopolysaccharides (EPSs), e.g., xanthan, dextran, gellan, curdlan, etc., have significant applications in several industries (pharma, food, textiles, petroleum, etc.) due to their biocompatibility, nontoxicity, and functional characteristics. However, biodegradability, poor cell adhesion, mineralization, and lower enzyme activity are some other factors that might hinder commercial applications in healthcare practices. Some EPSs lack biological activities that make them prone to degradation in ex vivo, as well as in vivo environments. The blending of EPSs with other natural and synthetic polymers can improve the structural, functional, and physiological characteristics, and make the composites suitable for a diverse range of applications. In comparison to EPS, composites have more mechanical strength, porosity, and stress-bearing capacity, along with a higher cell adhesion rate, and mineralization that is required for tissue engineering. Composites have a better possibility for biomedical and healthcare applications and are used for 2D and 3D scaffold fabrication, drug carrying and delivery, wound healing, tissue regeneration, and engineering. However, the commercialization of these products still needs in-depth research, considering commercial aspects such as stability within ex vivo and in vivo environments, the presence of biological fluids and enzymes, degradation profile, and interaction within living systems. The opportunities and potential applications are diverse, but more elaborative research is needed to address the challenges. In the current article, efforts have been made to summarize the recent advancements in applications of exopolysaccharide composites with natural and synthetic components, with special consideration of pharma and healthcare applications.

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Section: Microbial Exopolysaccharide Composites and Their Applicationsmentioning

confidence: 99%

Microbial Exopolysaccharide Composites in Biomedicine and Healthcare: Trends and Advances

et al. 2023

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“…However, some of the structural changes in chitosan derivatives and some types of crosslinks are less evident in these types of spectra. For example, the presence of Schiff base bonds could be confirmed by high resolution XPS spectroscopy [ 14 ], since in the FTIR and NMR spectra the imine bond gives low intensity signals and overlaps other bands or peaks [ 75 ].…”

Section: Chitosan-based Gel Materialsmentioning

confidence: 99%

Insights on Some Polysaccharide Gel Type Materials and Their Structural Peculiarities

Duceac¹,

Stanciu²,

Nechifor³

et al. 2022

Gels

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Global resources have to be used in responsible ways to ensure the world’s future need for advanced materials. Ecologically friendly functional materials based on biopolymers can be successfully obtained from renewable resources, and the most prominent example is cellulose, the well-known most abundant polysaccharide which is usually isolated from highly available biomass (wood and wooden waste, annual plants, cotton, etc.). Many other polysaccharides originating from various natural resources (plants, insects, algae, bacteria) proved to be valuable and versatile starting biopolymers for a wide array of materials with tunable properties, able to respond to different societal demands. Polysaccharides properties vary depending on various factors (origin, harvesting, storage and transportation, strategy of further modification), but they can be processed into materials with high added value, as in the case of gels. Modern approaches have been employed to prepare (e.g., the use of ionic liquids as “green solvents”) and characterize (NMR and FTIR spectroscopy, X ray diffraction spectrometry, DSC, electronic and atomic force microscopy, optical rotation, circular dichroism, rheological investigations, computer modelling and optimization) polysaccharide gels. In the present paper, some of the most widely used polysaccharide gels will be briefly reviewed with emphasis on their structural peculiarities under various conditions.

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“…In this regard, it seems particularly advantageous to use sodium periodate, a specific reagent, to oxidize the OH groups contained in the majority of polysaccharides. The unique property of this selective and specific reagent is that it simultaneously oxidizes the secondary OH groups of the glycosidic unit and breaks the bridge between C2 and C3, resulting in a reaction product with two aldehyde groups on the structural unit [ 10 , 29 , 42 , 43 , 44 , 45 ], Figure 2 .…”

Section: Fundamental Research: Focus On Materials Sciencementioning

confidence: 99%

“…Recently, in our group, a new type of Schiff-base hydrogel was obtained based on dialdehyde pullulan [ 42 ]. Dopamine was selected as a low molecular weight compound bearing an amine group that attached to the aldehyde moieties on the polysaccharide backbone and enabled the formation of a stable network.…”

Section: Fundamental Research: Focus On Materials Sciencementioning

confidence: 99%

“…Materials based on imine bonds were prepared for wound dressing applications and were proved to exhibit more than one feature of interest for this application. For example, hydrogels based on oxidized polysaccharides are proved to have an excellent hemostatic effect [ 42 ]. Moreover, the presence of bioactive molecules can accelerate the tissue repair and the wound closure [ 57 ].…”

Section: Applicative Research: Focus On Biomedical Technologiesmentioning

confidence: 99%

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Chitosan Schiff-Base Hydrogels—A Critical Perspective Review

Duceac¹,

Coseri²

2022

Gels

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Chitosan is quite a unique polysaccharide due to the presence of the amine groups naturally occurring in its structure. This feature renders it into a polycation which makes it appealing for preparing polyelectrolyte complexes or imine bonds gels. Therefore, the vast majority of hydrogels prepared using Schiff base chemistry have chitosan as one component. Usually, the counterpart is a low molecular weight aldehyde or a macromolecular periodate-oxidized polysaccharide, i.e., cellulose, pullulan, starch, alginate, hyaluronic acid, etc. Indisputable advantages of hydrogels include their quick gelation, no need for crosslinking agents, and self-healing and injectability properties. This gives grounds for further research, both fundamental in materials science and applicative in various domains. This article is a critical assessment of the most relevant aspects of this topic. It also provides a short review of some of the most interesting research reported in the literature supporting the main observations of this perspective.

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Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Cited by 23 publications

References 56 publications

Microbial Exopolysaccharide Composites in Biomedicine and Healthcare: Trends and Advances

Microbial Exopolysaccharide Composites in Biomedicine and Healthcare: Trends and Advances

Insights on Some Polysaccharide Gel Type Materials and Their Structural Peculiarities

Chitosan Schiff-Base Hydrogels—A Critical Perspective Review

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