Hemostatic Multilayer Coatings

Abstract

Spray layer-by-layer assembly is used to create hemostatic films containing thrombin and tannic acid. The spray assembly technique enables coating of porous and absorbent commercial gelatin sponges with these films. Coated sponges are able to promote instantaneous hemostasis in a porcine spleen bleeding model.

Choline phosphate functionalized cellulose membrane: A potential hemostatic dressing based on a unique bioadhesion mechanism

“…Generally, the traditional primary pressure-based methods for bleeding control are the usage of tourniquets, direct pressure, bandages, and clamping in most compressible cases; these have not changed greatly in several centuries [5][6][7]. Hemorrhage dressings, as an alternative to bleeding control, which work by enhancing the clotting process, have been well developed and commonly utilized on the battlefield and clinical trials [8,9].…”

Supramolecular design of coordination bonding architecture on zein nanoparticles for pH-responsive anticancer drug delivery

“…As an alcohol-soluble protein obtained from corn, zein has been extensively investigated in the encapsulation of bioactive compounds because of its capability to form self-assembled NPs and more importantly, its capability for sustained drug release [23,24]. Due to the binding affinity to neutral polymers [25] and proteins [26] via hydrogen bonding and hydrophobic interactions respectively, TA and metal ions, were utilized to form robust nanoscale films on zein NPs.…”

Layer-by-layer Nanoarchitectonics: Invention, Innovation, and Evolution

“…Hammond developed a method for hemostatic LbL multilayer coatings using only materials approved by the United States Food and Drug Administration (FDA). 376 This LbL assembly is based on hydrogen-bonding interactions with bio-originated material such as tannic acid and bovine thrombin without incorporation of any synthetic polymers. The materials prepared were applied to a clinically available porous and absorbent gelatin sponge.…”