Henoch–Schönlein purpura

Saulsbury, Frank T.

doi:10.1097/bor.0b013e32833af608

Cited by 185 publications

(78 citation statements)

References 31 publications

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“…A potential implication of an aberrant glycosylation of the hinge region of IgA1 has been implicated in its pathogenesis [42]. Regrettably, information on the genetic implication in the susceptibility and severity of IgAV is generally limited to small case series [43], which in many cases Odds ratio for the discovery cohort.…”

Section: Immunoglobulin a Vasculitis (Henoch-schö Nlein)mentioning

confidence: 99%

Genetics of vasculitis

Carmona

Martín

González-Gay

2015

Current Opinion in Rheumatology

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The analysis of high-throughput genotyping and exome-sequencing data has produced a considerable advance in the identification of consistent genetic risk factors in vasculitides during the last 3 years. Further collaborative efforts, which will increase the sample size, and the use of custom arrays like the immunochip, will definitively help to better understand the genetic basis of vasculitides and to identify the common and specific molecular pathways underlying their pathophysiology.

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Section: Immunoglobulin a Vasculitis (Henoch-schö Nlein)mentioning

confidence: 99%

Genetics of vasculitis

Carmona

Martín

González-Gay

2015

Current Opinion in Rheumatology

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“…It is a leukocytoclastic vasculitis which is a consequence of subendothelial storage of IgA (only IgA 1 subclass) immune complexes in small arteries and capillaries. Therefore, IgAV was commonly seen after various viral and bacterial infections [1,2]. But, generally the exact etiology was remaining undetected in most cases, as in our patient.…”

Section: Discussionmentioning

confidence: 53%

Posterior reversible encephalopathy syndrome in IgA vasculitis: Neuroimaging of a 14-year-old child

Arslan

Yavuz

Arslan

et al. 2018

Neurologia i Neurochirurgia Polska

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IgA vasculitis (IgAV) is a leukocytoclastic vasculitis and characterized by involvement of small vessels in skin, gastrointestinal system, joints, kidneys, and less frequently other organs. It is the commonest vasculitis in childhood and etiology is not completely known. Neurological manifestations of IgAV are very rare and usually seen in patients with severe hypertension or as an uncommon feature such as peripheral neuropathy. Posterior reversible encephalopathy syndrome (PRES) is a clinic-radiologic entity characterized with temporary vasogenic edema developing typically in posterior circulation of the brain and has been reported as a rare manifestation of IgAV. In this paper, a PRES case of 14-year-old male with IgAV is reported and etiopathogenesis was discussed with literature. Diagnosis was made by magnetic resonance imaging because of the existence of neurological symptoms (headache and visual loss) during the course of disease. His radiological findings have resolved with therapy. Although neurological involvement is a rare manifestation in IgAV, we recommend magnetic resonance imaging in such patients for diagnosis and evaluation of complications.

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“…Abnormalities of IgA1 glycosylation might provide one clue to the genetic basis for HSP and IgAN. Several HLA types (DRB*01, DRB1*11, DRB1*14, HLA-B35) have been associated with susceptibility to HSP [33], but efforts to identify a gene that causes HSP or IgAN have failed.…”

Section: Discussionmentioning

confidence: 99%