2005
DOI: 10.1128/jvi.79.20.12692-12702.2005
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Heparan Sulfate Proteoglycans Mediate Attachment and Entry of Human T-Cell Leukemia Virus Type 1 Virions into CD4 + T Cells

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Cited by 169 publications
(169 citation statements)
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References 81 publications
(120 reference statements)
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“…GLUT1, heparin sulfate proteoglycan(HSPG) and neuropilin-1 are the three molecules that are reported as key players for the interaction between the viral envelop and the cell membrane, and for the entry into the cells [24][25][26]. It has been proposed that HTLV-1 particles first contact HSPG, then neuropilin-1 recruits HTLV-1/ HSPG complex to present them to GLUT1.…”
Section: Mechanisms Of Htlv-1 Transmissionmentioning
confidence: 99%
“…GLUT1, heparin sulfate proteoglycan(HSPG) and neuropilin-1 are the three molecules that are reported as key players for the interaction between the viral envelop and the cell membrane, and for the entry into the cells [24][25][26]. It has been proposed that HTLV-1 particles first contact HSPG, then neuropilin-1 recruits HTLV-1/ HSPG complex to present them to GLUT1.…”
Section: Mechanisms Of Htlv-1 Transmissionmentioning
confidence: 99%
“…The replication cycle of HTLV-1 begins with the interaction between the viral Env glycoproteins and the specific cellular receptor proteins. At least three cellular receptors have been found to facilitate viral attachment and entry into the cell, and these include the glucose transporter 1 (GLUT1) [24,25], neuropilin-1 (NRP-1) [26][27][28], and heparan sulfate proteoglycans (HSPG) [29][30][31]. During the membrane fusion process and after entry of the viral capsid into the cytoplasm, the viral genomic RNA is reverse transcribed into DNA, by the viral particle-associated reverse transcriptase.…”
Section: Htlv-1 Genetic Architecture and Viral Replicationmentioning
confidence: 99%
“…An absence or decrease in PG-core proteins may therefore reduce the expression of GAGs and potentially cause an insufficient interaction between bacteria and host cells, thereby preventing infection [25]. We therefore compared PG-core protein gene expression (Fig.…”
Section: Jurkat Cells and Hep-2 Cellsmentioning
confidence: 99%