2021
DOI: 10.1016/j.matbio.2021.05.001
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Heparanase 2 (Hpa2) attenuates tumor growth by inducing Sox2 expression

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Cited by 20 publications
(29 citation statements)
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“…4), suggesting that these properties of Hpa2 are mediated, at least in part, by AMPK. The role of AMPK in Hpa2-mediated tumor attenuation awaits stringent confirmation in a subsequent study, employing gastric, head and neck, pancreatic [ 25 , 27 , 57 ], or other types of cancer that are affected by Hpa2 and show increased levels of AMPK phosphorylation.…”
Section: Discussionmentioning
confidence: 99%
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“…4), suggesting that these properties of Hpa2 are mediated, at least in part, by AMPK. The role of AMPK in Hpa2-mediated tumor attenuation awaits stringent confirmation in a subsequent study, employing gastric, head and neck, pancreatic [ 25 , 27 , 57 ], or other types of cancer that are affected by Hpa2 and show increased levels of AMPK phosphorylation.…”
Section: Discussionmentioning
confidence: 99%
“…https://kmplot.com/analysis Experimentally, overexpression of Hpa2 in head and neck and pancreatic carcinoma cells resulted in a prominent decrease in tumor growth, mediated by lower vascular density (blood and lymph vessels) [25] , likely due to reduced Id1 expression, a transcription factor highly implicated in VEGF-A and VEGF-C gene regulation [26] . Tumors produced by cells overexpressing Hpa2 were not only smaller but also exhibited a higher degree of cell differentiation (i.e., cytokeratin expression) [ 25 , 27 ], thus strengthening the significance of Hpa2 as a tumor suppressor [20] . Likewise, high levels of Hpa2 were associated with lower tumor grade [ 28 , 29 ], further associating Hpa2 with cell differentiation.…”
Section: Introductionmentioning
confidence: 99%
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“…The specific biological role, or roles, of heparanase-2 are less clear but the protein has the abilities to bind heparin and heparin sulphate, and to inhibit the enzymatic (e.g., heparan sulfate degrading) activity of classical heparanase ( Levy-Adam et al, 2010 ), here called heparanase-1, by outcompeting binding to its heparan sulfate substrate. Heparanase-2 also modulates both the migration of human tumour cells in vitro and experimental tumour growth in vivo ( Gross-Cohen et al, 2021a ; Gross-Cohen et al, 2021b ).…”
Section: Introductionmentioning
confidence: 99%
“…The SOX (SRY homology box) proteins affect stem cell function and fate by regulating the expression of genes involved in self-renewal and multipotency [ 35 , 36 , 37 ]. These proteins are overexpressed in many different tumors [ 38 ].…”
Section: Introductionmentioning
confidence: 99%