2024
DOI: 10.15407/ubj96.05.005
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Heparin-binding EGF-like growth factor: mechanisms of biological activity and potential therapeutic applications

L. M. Dronko,
T. M. Lutsenko,
N. V. Korotkevych
et al.

Abstract: The diphtheria toxin receptor on sensitive mammalian cells is known as the membrane anchored precursor of heparin-binding EGF-like growth factor (HB-EGF). When the precursor is cleaved by metalloproteinases, a soluble form (sHB-EGF) is formed that can bind to the EGF receptors, resulting in activation of signaling pathways that regulate cell proliferation, differentiation, migration, and inhibition of apoptosis. The ability of HB-EGF to cause both positive and negative consequences for organism underscores the… Show more

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