Heparin-bonded central venous lines reduce thrombotic and infective complications in critically ill children

Abstract

Our study shows a significant reduction in the incidence of infection and thrombosis associated with the use of HB CVLs.

Risk factors for healthcare-associated infection in pediatric intensive care units: a systematic review

“…### Reported in the study by Almuneef et al 83 ; the study by Elward et al 59 only mentions reintubation; § Almuneef et al 83 -patient on mechanical ventilation for at least 48 hours, presenting new or progressive infi ltrate, consolidation, cavitation or pleural effusion on the thorax radiography. Additionally, the patient must have: appearance of purulent sputum or change in the appearance of phlegm; microorganism isolated in the blood culture not related to other source of infection; isolation of pathogens of specimen obtained from tracheal aspiration, bronchoalveolar lavage or protected pulmonary brushing or biopsy; or histopathologic with evidence of pneumonia in pulmonary biopsy.…”

Risk Factors for Nosocomial Primary Bloodstream Infection in Pediatric Intensive Care Unit Patients: A 2-Year Prospective Cohort Study

“…[1][2][3][4] Central venous catheter (CVC)-associated BSI rates in PICUs range from 7.7 to 46.9 infections per 1,000 CVC-days. [4][5][6][7][8][9] These rates are comparable to BSI rates found in burn units and neonatal intensive care units. 6 Coagulasenegative staphylococci are the most common pathogens identified among patients with catheter-related BSI (38% of episodes), although gram-negative rods are isolated in 25% of PICU bacteremia cases.…”

Guidelines for the prevention of intravascular catheter-related infections

“…The majority are heparin-bonded with benzalkonium chloride, which provides the catheters with antimicrobial activity [123] and provides an anti-thrombotic effect [124].…”