Hepatic and Thymic Alterations in Newborn Offspring of Malnourished Rat Dams

Schüler, S; Gurmini, Jocemara; Cecílio, William Augusto Casteleins; Azevedo, Marina Luise Viola de; Olandoski, Márcia; Noronha, Lúcia de

doi:10.1177/0148607108314387

Cited by 9 publications

(7 citation statements)

References 27 publications

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“…Parotid glands from male Wistar rats were submerged in paraffin blocks We used tissue microarrays (TMAs) containing ten cylinders of paraffinized salivary glands (3 um in diameters), which were organized in lines and columns (Rocha et al, 2006 ; Schuler et al, 2008 ). Each TMA exhibited ten specimens of salivary glands from rats of each group.…”

Section: Methodsmentioning

confidence: 99%

Effects of Benzodiazepines on Acinar and Myoepithelial Cells

et al. 2016

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Background: Benzodiazepines (BZDs), the most commonly prescribed psychotropic drugs with anxiolytic action, may cause hyposalivation. It has been previously shown that BZDs can cause hypertrophy and decrease the acini cell number. In this study, we investigated the effects of BZDs and pilocarpine on rat parotid glands, specifically on acinar, ductal, and myoepithelial cells.Methods: Ninety male Wistar rats were divided into nine groups. Control groups received a saline solution for 30 days (C30) and 60 days (C60), and pilocarpine (PILO) for 60 days. Experimental groups received lorazepam (L30) and midazolam (M30) for 30 days. Another group (LS60 or MS60) received lorazepam or midazolam for 30 days, respectively, and saline for additional 30 days. Finally, other groups (LP60 or MP60) received either lorazepam or midazolam for 30 days, respectively, and pilocarpine for additional 30 days. The expression of calponin in myoepithelial cells and the proliferating cell nuclear antigen (PCNA) in acinar and ductal cells were evaluated.Results: Animals treated with lorazepam showed an increase in the number of positive staining cells for calponin as compared to control animals (p < 0.05). Midazolam administered with pilocarpine (MP60) induced an increase in the proliferation of acinar and ductal cells and a decrease in the positive staining cells for calponin as compared to midazolam administered with saline (MS60).Conclusion: We found that myoepithelial cells might be more sensitive to the effects of BZD than acinar and ductal cells in rat parotid glands.

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Section: Methodsmentioning

confidence: 99%

Effects of Benzodiazepines on Acinar and Myoepithelial Cells

et al. 2016

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“…Malnutrition usually permanently stunts the development of lymphoid organs. In rats, for example, malnutrition in dams caused impairment in the thymus [77]. Secondary to thymic atrophy, the production of thymic hormones that are critical for the differentiation of T lymphocytes was reduced, especially in protein-calorie malnutrition and zinc deficiency [49].…”

Section: Early Malnutrition and Immunitymentioning

confidence: 99%

“…A severe state of protein-energy malnutrition significantly diminished the intestine length of rats compared with control animals [77]. Intestinal weight and total DNA were similarly diminished in the malnourished rats [37].…”

Section: Early Malnutrition On Development Of the Gastrointestinal Tractmentioning

confidence: 99%

Effects of Early Malnutrition on Mental System, Metabolic Syndrome, Immunity and the Gastrointestinal Tract

Sun

Liu

et al. 2009

J. Vet. Med. Sci.

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ABSTRACT. The notion of how malnutrition early in life affects ontogenesis has evolved considerably since the mid-1960s. Since then, there have been many studies on the effects of early malnutrition. Nutritional and metabolic exposure during critical periods in early human and animal development may have long-term programming effects in adulthood. This is supported by evidence from epidemiological studies, numerous animal models and clinical intervention trials. In this paper, we review the effects of early malnutrition on cognitive function, metabolic syndrome, immunity and the gastrointestinal tract, as well as possible underlying mechanisms, and consider diarrhoeal disease and poor cognitive function as examples for understanding the interrelation of the harmful effects caused by early malnutrition. Previous studies on early malnutrition have mainly concentrated on humans and rats. Therefore, the main aim of the present review was to give animal scientists a clear understanding of the harmful effects of early malnutrition on animal growth and animal production, and to help identify appropriate feeding techniques to prevent early malnutrition.KEY WORDS: early malnutrition, gastrointestinal development, immunity, metabolic syndrome.

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“…Immunohistochemistry (IHC) reactions were performed in sections of breast cancer from a tissue microarray (TMA) block [17]. The TMA consisted of 49 breast cancer cases, 38 IDC samples and 11 ILC samples.…”

Section: Immunohistochemistrymentioning

confidence: 99%

ADAM33 as a New Biomarker for Invasive Lobular Breast Carcinoma

Manica¹

2013

J Cancer Sci Ther

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Invasive ductal carcinoma (IDC) and invasive lobular breast carcinoma (ILC) are the most common malignancies compromising the breast tissue in women worldwide. ILCs tend to form metastasisin remote locations, such as the gastrointestinal tract, peritoneal surface and retroperitoneum, compared with IDCs that move preferentially to the lymph nodes, lung, pleura, liver, brain and bones. The histological characteristics of these two tumors are very similar and there is no useful molecular marker to differentiate IDC from ILC to date. In this study, we cloned and expressed ADAM33 recombinant protein cystein rich domain in order to produce polyclonal antibodies and used it as a new immnunohistochemical molecular biomarker that specifically recognizes the ILC breast cancer subtype.

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Hepatic and Thymic Alterations in Newborn Offspring of Malnourished Rat Dams

Abstract: Malnutrition in dams causes alterations in the liver, thymus, and other internal organs of newborn offspring. Significant changes in thymuses were found using human monoclonal antibodies that cross-react with rat proteins, a novel finding in the literature.

Cited by 9 publications

References 27 publications

Effects of Benzodiazepines on Acinar and Myoepithelial Cells

Effects of Benzodiazepines on Acinar and Myoepithelial Cells

Effects of Early Malnutrition on Mental System, Metabolic Syndrome, Immunity and the Gastrointestinal Tract

ADAM33 as a New Biomarker for Invasive Lobular Breast Carcinoma

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