Hepatic Biotransformation and Biliary Excretion

Novel analogs of antitumor agent calixarene 0118: Synthesis, cytotoxicity, click labeling with 2-[18F]fluoroethylazide, and in vivo evaluation

“…The slower blood clearance of [ 18 F]6 in the elimination phase is paralleled by the higher lipophilicity of this tracer, presumably giving rise to increased plasma protein binding [39]. Alternatively, the slower clearance may partly be due to enterohepatic recycling, i.e., intestinal reabsorption of the tracer after biliary excretion [40], a mechanism supported by the predominant and fast hepatobiliary clearance of [ 18 F]6 (Fig. 4A).…”